-
公开(公告)号：US12215369B2
公开(公告)日：2025-02-04
申请号：US17750293
申请日：2022-05-20
Applicant: Braskem S.A.
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
-
公开(公告)号：US11566269B2
公开(公告)日：2023-01-31
申请号：US17163838
申请日：2021-02-01
Applicant: Braskem S.A.
Inventor： Paulo Moises Raduan Alexandrino , Iuri Estrada Gouvea , Veronica Leite Queiroz , Marcos Rogerio Simões
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
-
公开(公告)号：US11530391B2
公开(公告)日：2022-12-20
申请号：US16378209
申请日：2019-04-08
Applicant: Braskem S.A.
Inventor： Verônica Leite Queiroz , Lucas Pedersen Parizzi , Iuri Estrada Gouvea , Debora Noma Okamoto , Rafael Victório Carvalho Guido , Alessandro Silva Nascimento , Igor Polikarpov
Abstract: The present disclosure relates to biological processes and systems for the production of isopropanol and/or acetone utilizing modified alcohol dehydrogenases that exhibit increased activity with NADH as a cofactor. The disclosure further relates to polynucleotides and polypeptides of the modified alcohol dehydrogenases, and host cells containing the polynucleotides and expressing the polypeptides.
-
14.发明申请公开(公告)号：US20210371622A1
公开(公告)日：2021-12-02
申请号：US17333317
申请日：2021-05-28
Applicant: Braskem S.A.
Inventor： Felipe Cicaroni Fernandes , Iuri Estrada Gouvea , Antonio Rodolfo, JR. , Mateus Schreiner Garcez Lopes
IPC: C08K5/1535 , C08K5/00 , C08L27/06 , C08J3/18 , C08J3/12 , C07D307/68
Abstract: The present disclosure generally relates to a compound of dialkyl ester of 2,4-furandicarboxylic acid, a method of preparing the compound, a polymer composition comprising a polymer and the compound, a method of preparing the polymer composition, a polymer product comprising the polymer composition and a method of using the compound as a plasticizer in the polymer product. The dialkyl ester of 2,4-furandicarboxylic acid of the present disclosure has greater plasticizing efficiency in a polymer composition that that of the standard phthalate and terephthalate-based plasticizers. The polymer product plasticized with the dialkyl ester of 2,4-furandicarboxylic acid may have improved flexibility, durability, processability and safety as compared to the same polymer product plasticized with conventional phthalate and terephthalate-based plasticizers.
-
公开(公告)号：US20150240264A1
公开(公告)日：2015-08-27
申请号：US14627205
申请日：2015-02-20
Applicant: BRASKEM S.A.
Abstract: The present disclosure generally relates to microorganisms (e.g., non-naturally occurring microorganisms) that comprise one or more polynucleotides coding for enzymes in a pathway that catalyze a conversion of a carbon source (e.g., a fermentable carbon source) to terpene, succinate, and hydrogen and the use of such microorganisms for the production of terpene, succinate, and hydrogen.
Abstract translation: 本公开内容通常涉及包含一种或多种编码催化碳源（例如可发酵碳源）转化为萜烯，琥珀酸酯和 氢和使用这些微生物来生产萜烯，琥珀酸和氢。
-
Patent Agency Ranking
公开(公告)号：US11692210B2
公开(公告)日：2023-07-04
申请号：US17464139
申请日：2021-09-01
Applicant: Braskem S.A.
Inventor： Iuri Estrada Gouvea , Marcos Rogerio Simoes , Mariana Trovo Marchesin , Aline Silva Romão Dumaresq
CPC classification number: C12P17/04 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/1205 , C12N9/1217 , C12N9/88 , C12N9/93 , C12Y101/01001 , C12Y102/0101 , C12Y203/01008 , C12Y207/01019 , C12Y207/02012 , C12Y401/01039 , C12Y401/02009 , C12Y401/02022 , C12Y602/01001 , C12N15/81
Abstract: The present disclosure provides recombinant microorganisms and methods for the anaerobic production of 2,4-furandicarboxylic acid from one or more carbon sources. The microorganisms and methods provide redox-balanced and ATP positive pathways for co-producing 2,4-furandicarboxylic acid with ethanol and for co-producing 2,4-furandicarboxylic acid with ethanol and 1-propanol. The method provides recombinant microorganisms that express endogenous and/or exogenous nucleic acid molecules encoding polypeptides that catalyze the conversion of a carbon source into 2,4-furandicarboxylic acid and that coupled the 2,4-furandicarboxylic acid pathway with an additional metabolic pathway.
-
17.发明授权公开(公告)号：US11578347B2
公开(公告)日：2023-02-14
申请号：US17463988
申请日：2021-09-01
Applicant: Braskem S.A.
Inventor： Iuri Estrada Gouvea , Ana Karina Brambilla Costa , Marcos Rogerio Simoes , Veronica Leite Queiroz , Aline Silva Romão Dumaresq
Abstract: The present disclosure provides recombinant microorganisms and methods for the anaerobic production of 2,4-furandimethanol from one or more carbon sources. The microorganisms and methods provide redox-balanced and ATP positive pathways for co-producing 2,4-furandimethanol with ethanol and for co-producing 2,4-furandimethanol with ethanol and acetone and/or isopropanol. The method provides recombinant microorganisms that express endogenous and/or exogenous nucleic acid molecules encoding polypeptides that catalyze the conversion of a carbon source into 2,4-furandimethanol and that couple the 2,4-furandimethanol pathway with an additional metabolic pathway. The present disclosure further provides enzymatic production of 2,4-furandicarboxylic acid.
-
公开(公告)号：US11339414B2
公开(公告)日：2022-05-24
申请号：US16806728
申请日：2020-03-02
Applicant: Braskem S.A.
IPC: C12P17/04 , C07D307/68 , C12N9/88 , C12N9/04 , C12N9/02 , C12N9/08 , C12N9/16 , C12N1/19 , C12N1/21
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
-
公开(公告)号：US11286490B2
公开(公告)日：2022-03-29
申请号：US16317406
申请日：2017-07-12
Applicant: BRASKEM S.A.
Inventor： Mateus Schreiner Lopes , Daniel Johannes Koch , Iuri Estrada Gouvea , Debora Noma Okamoto , Veronica Leite Queiroz
Abstract: The present application relates to recombinant microorganisms expressing a dehydratase useful in a one-step, direct fermentative production of one or more primary alkenes from one or more saturated primary or secondary alcohols. Known, well developed high-yielding pathways that use renewable feedstock can be introduced into the recombinant microorganisms to obtain the alcohol precursors. Also provided are methods of producing one or more primary alkenes using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally the primary alkene products.
-
公开(公告)号：US10941454B2
公开(公告)日：2021-03-09
申请号：US15578488
申请日：2016-05-26
Applicant: GENOMATICA, INC. , BRASKEM S.A.
Inventor： Stephanie J. Culler , Robert J. Haselbeck , Harish Nagarajan , Iuri Estrada Gouvea , Daniel Johannes Koch , Mateus Schreiner Garcez Lopes , Lucas Pedersen Parizzi
Abstract: In alternative embodiments, provided are non-natural or genetically engineered vinylisomerase-dehydratase enzymes, including alkenol dehydratases, linalool dehydratases and crotyl alcohol dehydratases. In alternative embodiments, provided are non-natural or genetically engineered polypeptides having an activity comprising, for example, a vinylisomerase-dehydratase, an alkenol dehydratase, a linalool dehydratase and/or a crotyl alcohol dehydratase activity, or a combination thereof. In alternative embodiments, also provided are non-natural or genetically engineered nucleic acids (polynucleotides) encoding polypeptides described herein, expression or cloning vehicles comprising or having contained therein nucleic acids as described herein, and non-natural or genetically engineered cells comprising or having contained therein nucleic acids as described herein. In alternative embodiments, also provided are methods for making various organic compounds, including methyl vinyl carbinol and butadiene.
-
-
-
-
-
-
-
-
-
Search Results
25
records
(took 0.013 seconds)
