公开(公告)号：US11173219B2

公开(公告)日：2021-11-16

申请号：US16520965

申请日：2019-07-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Paul E. Morin ,  David Donnelly ,  Dasa Lipovsek ,  Jochem Gokemeijer ,  Maria Jure-Kunkel ,  David Fabrizio ,  Martin C. Wright ,  Douglas Dischino ,  Samuel J. Bonacorsi, Jr. ,  Ralph Adam Smith ,  Virginie LaFont ,  Daniel Cohen

IPC: A61K51/08 ,  C07K14/78 ,  G01N33/574 ,  C12N5/00 ,  C12N15/09 ,  G01N33/60 ,  G01N33/68

Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

公开(公告)号：US10934572B2

公开(公告)日：2021-03-02

申请号：US16244921

申请日：2019-01-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael L. Gosselin ,  David Fabrizio ,  Joanna F. Swain ,  Tracy Mitchell ,  Ray Camphausen ,  Sharon T. Cload ,  Eric Furfine ,  Paul E. Morin ,  Ranjan Mukherjee ,  Simeon I. Taylor

IPC: C12P21/00 ,  C12N15/62 ,  A61K47/62 ,  A61K47/64 ,  C07K14/78 ,  C07K14/435 ,  C07K14/50 ,  C07K14/575 ,  A61K38/00

Abstract: The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.

公开(公告)号：US11344639B2

公开(公告)日：2022-05-31

申请号：US16305284

申请日：2017-05-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Paul E. Morin ,  David Donnelly ,  Dasa Lipovsek ,  Jochem Gokemeijer ,  Maria Jure-Kunkel ,  David Fabrizio ,  Martin C. Wright ,  Douglas Dischino ,  Samuel J. Bonacorsi, Jr. ,  Ralph Adam Smith ,  Virginie Lafont ,  Daniel Cohen ,  David K. Leung

IPC: A61K51/08 ,  C07B59/00 ,  C07K16/28

Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

公开(公告)号：US10442851B2

公开(公告)日：2019-10-15

申请号：US15127166

申请日：2015-03-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tracy S. Mitchell ,  Michael L. Gosselin ,  Dasa Lipovsek ,  Rex Parker ,  Ray Camphausen ,  Jonathan Davis ,  David Fabrizio

IPC: C07K14/78 ,  A61K47/64 ,  A61K38/00

Abstract: The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.

公开(公告)号：US10406251B2

公开(公告)日：2019-09-10

申请号：US15529260

申请日：2015-11-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Paul E. Morin ,  David Donnelly ,  Dasa Lipovsek ,  Jochem Gokemeijer ,  Maria N. Jure-Kunkel ,  David Fabrizio ,  Martin C. Wright ,  Douglas Dischino ,  Samuel J. Bonacorsi, Jr. ,  Ralph Adam Smith ,  Virginie Lafont ,  Daniel Cohen

IPC: A61K51/08 ,  C07K14/78 ,  G01N33/60 ,  G01N33/68 ,  G01N33/574

Abstract: Provided herein are novel polypeptides comprising fibronectin type III tenth (10Fn3) domains which specifically bind to Programmed Death Ligand-1 (PD-L1), as well as imaging agents based on the same for diagnostics.