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公开(公告)号：US20180297954A1
公开(公告)日：2018-10-18
申请号：US15767364
申请日：2016-10-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Soong-Hoon Kim , Hannguang J. Chao , Heather Finlay , Ji Jang , James A. Johnson , R. Michael Lawrence , Michael C. Myers , Monique Phillips , George O. Tora , Wei Meng
IPC: C07D213/82 , C07D401/12 , C07D401/14 , C07D413/14 , C07D401/06 , C07D405/14 , C07D417/14 , C07D417/12 , C07D498/10 , C07D413/12 , C07D491/107 , C07D471/10
CPC classification number: C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/107 , C07D498/10
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, O and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20180273518A1
公开(公告)日：2018-09-27
申请号：US15990855
申请日：2018-05-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D417/14 , C07D498/04 , C07D401/04 , C07D413/14
CPC classification number: C07D413/04 , C07D401/04 , C07D413/14 , C07D417/14 , C07D498/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US10011594B2
公开(公告)日：2018-07-03
申请号：US15171276
申请日：2016-06-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D413/14 , C07D401/04 , C07D417/14 , C07D498/04
CPC classification number: C07D413/04 , C07D401/04 , C07D413/14 , C07D417/14 , C07D498/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20220331402A1
公开(公告)日：2022-10-20
申请号：US17721569
申请日：2022-04-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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15.发明授权公开(公告)号：US11224634B2
公开(公告)日：2022-01-18
申请号：US17198939
申请日：2021-03-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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Patent Agency Ranking
16.发明授权公开(公告)号：US11185570B2
公开(公告)日：2021-11-30
申请号：US16287342
申请日：2019-02-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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公开(公告)号：US20210198246A1
公开(公告)日：2021-07-01
申请号：US15779194
申请日：2016-12-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Wei Meng , Hannguang J. Chao , Heather Finlay , R. Michael Lawrence , Michael C. Myers
IPC: C07D413/10 , C07D401/12 , C07D239/54 , C07D403/10 , C07D413/06 , C07D417/06 , C07D401/10 , C07D401/14 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20190263791A1
公开(公告)日：2019-08-29
申请号：US16411221
申请日：2019-05-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D417/14 , C07D498/04 , C07D413/14 , C07D401/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20170275272A1
公开(公告)日：2017-09-28
申请号：US15468230
申请日：2017-03-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: C07D403/06 , C07D471/04 , C07D417/14 , C07D401/14
CPC classification number: C07D403/06 , A61K31/505 , C07D239/54 , C07D239/545 , C07D239/557 , C07D401/06 , C07D401/14 , C07D403/02 , C07D403/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20250011288A1
公开(公告)日：2025-01-09
申请号：US18701270
申请日：2022-10-28
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Adam James Clarke , Todd J. Friends , Arvind Mathur , Michael C. Myers , Jianqing Li , Donald J. P. Pinto , Kumar Balashanmuga Pabbisetty , Shun Su , Benjamin P. Vokits , Durga Buchi Raju Barre , Leon M. Smith, II , Michael J. Orwat , Scott A. Shaw , Sreekantha Ratna Kumar , Hima Kiran Potturi
IPC: C07D213/82 , A61K31/343 , A61K31/353 , A61K31/381 , A61K31/415 , A61K31/416 , A61K31/42 , A61K31/423 , A61K31/424 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/47 , A61K31/4704 , A61K31/496 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/5383 , A61K31/541 , C07D215/54 , C07D217/02 , C07D217/04 , C07D217/08 , C07D231/18 , C07D231/22 , C07D231/54 , C07D237/24 , C07D239/34 , C07D241/24 , C07D261/04 , C07D307/00 , C07D311/24 , C07D333/38 , C07D401/06 , C07D405/12 , C07D413/04 , C07D417/14 , C07D471/04 , C07D491/107 , C07D498/04
Abstract: The disclosure relates to compounds of Formula (I), which arm RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension). Formula (I)
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