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    Systems and methods for using sensed pressure for neuro cardiac therapy
    12.
    发明授权
    Systems and methods for using sensed pressure for neuro cardiac therapy 有权
    使用感测压力进行神经心脏治疗的系统和方法

    公开(公告)号：US09393417B2

    公开(公告)日：2016-07-19

    申请号：US13309328

    申请日：2011-12-01

    申请人： Shantha Arcot-Krishnamurthy ,  Barun Maskara

    发明人： Shantha Arcot-Krishnamurthy ,  Barun Maskara

    IPC分类号： A61B5/02 ,  A61N1/36 ,  A61B5/0215 ,  A61B5/08 ,  A61N1/365 ,  A61N1/05

    CPC分类号： A61N1/36114 ,  A61B5/0215 ,  A61B5/0823 ,  A61N1/36117 ,  A61N1/36139 ,  A61N1/36564 ,  A61N2001/0585

    摘要： A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable pressure sensor, and a pressure analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable pressure sensor is configured to be implanted in the cervical region and to detect pressure changes in the cervical region caused by laryngeal vibrations. The pressure sensor is configured to generate sensed pressure values. The pressure analyzer is configured to analyze the sensed pressure values generated by the pressure sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed pressure values.

    摘要翻译： 设备实施例被配置为将迷走神经刺激治疗（VST）递送到患者的迷走神经。 装置实施例包括神经刺激器，可植入压力传感器和压力分析器。 神经刺激器被配置成将VST输送到患者的颈部区域中的迷走神经。 植入式压力传感器被配置成植入颈部区域并且检测由喉部振动引起的颈部区域的压力变化。 压力传感器被配置为产生感测的压力值。 压力分析器被配置为分析由压力传感器产生的感测压力值。 分析器被配置为检测来自感测的压力值的喉部振动或咳嗽。

    SYSTEMS AND METHODS FOR USING SENSED PRESSURE FOR NEURO CARDIAC THERAPY
    14.
    发明申请
    SYSTEMS AND METHODS FOR USING SENSED PRESSURE FOR NEURO CARDIAC THERAPY 有权
    用于神经细胞治疗的感觉压力的系统和方法

    公开(公告)号：US20120172741A1

    公开(公告)日：2012-07-05

    申请号：US13309328

    申请日：2011-12-01

    申请人： Shantha Arcot-Krishnamurthy ,  Barun Maskara

    发明人： Shantha Arcot-Krishnamurthy ,  Barun Maskara

    IPC分类号： A61N1/372 ,  A61B5/08 ,  A61N1/365

    CPC分类号： A61N1/36114 ,  A61B5/0215 ,  A61B5/0823 ,  A61N1/36117 ,  A61N1/36139 ,  A61N1/36564 ,  A61N2001/0585

    摘要： A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable pressure sensor, and a pressure analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable pressure sensor is configured to be implanted in the cervical region and to detect pressure changes in the cervical region caused by laryngeal vibrations. The pressure sensor is configured to generate sensed pressure values. The pressure analyzer is configured to analyze the sensed pressure values generated by the pressure sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed pressure values.

    摘要翻译： 设备实施例被配置为将迷走神经刺激治疗（VST）递送到患者的迷走神经。 装置实施例包括神经刺激器，可植入压力传感器和压力分析器。 神经刺激器被配置成将VST输送到患者的颈部区域中的迷走神经。 植入式压力传感器被配置成植入颈部区域并且检测由喉部振动引起的颈部区域的压力变化。 压力传感器被配置为产生感测的压力值。 压力分析器被配置为分析由压力传感器产生的感测压力值。 分析器被配置为检测来自感测的压力值的喉部振动或咳嗽。

    Method and device for cardiac vasoactive therapy
    15.
    发明授权
    Method and device for cardiac vasoactive therapy 失效
    心脏血管活性治疗的方法和装置

    公开(公告)号：US08600499B2

    公开(公告)日：2013-12-03

    申请号：US11566896

    申请日：2006-12-05

    申请人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Joseph Walker

    发明人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Joseph Walker

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61F2/82 ,  A61N1/3688

    摘要： A method and device for treating myocardial ischemia in which an implantable pulse generator delivers electrical stimulation to electrodes disposed near a coronary artery. The stimulation parameters may be adjusted to produce vasodilation and/or vasoconstriction of the artery. The device may be configured to operate in a vasodilation and/or vasoconstriction mode in accordance with specified entry and exit conditions.

    摘要翻译： 一种用于治疗心肌缺血的方法和装置，其中植入式脉冲发生器将电刺激递送到设置在冠状动脉附近的电极。 可以调节刺激参数以产生动脉的血管舒张和/或血管收缩。 该装置可以被配置为根据指定的入口和出口条件在血管舒张和/或血管收缩模式中操作。

    Closed-loop control of intermittent excitatory cardiac stimulation for therapeutic effect
    17.
    发明授权
    Closed-loop control of intermittent excitatory cardiac stimulation for therapeutic effect 有权
    间歇兴奋性心脏刺激闭环控制治疗效果

    公开(公告)号：US08131363B2

    公开(公告)日：2012-03-06

    申请号：US11860957

    申请日：2007-09-25

    申请人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Christopher Hartemink

    发明人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Christopher Hartemink

    IPC分类号： A61N1/365 ,  A61N1/362

    CPC分类号： A61N1/3627

    摘要： A device and method for delivering electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The stimulation is delivered as high-output pacing in which the stimulation is excitatory and also of sufficient energy to augment myocardial contractility. In order to provide a consistent hemodynamic response, the high-output pacing is optimized by delivering it using different parameter sets, evaluating the hemodynamic response thereto as reflected by one or more measured physiological variables, and selecting the parameter set with the best hemodynamic response.

    摘要翻译： 用于向心脏递送电刺激以改善心力衰竭患者的心脏功能的装置和方法。 刺激作为高产出起搏，其中刺激是兴奋性的，并且具有足够的能量以增加心肌收缩力。 为了提供一致的血流动力学响应，通过使用不同的参数组递送高输出起搏，通过一个或多个测量的生理变量反映的血液动力学响应进行评估，并且选择具有最佳血液动力学响应的参数集来优化高输出起搏。

    INTERMITTENT PACING THERAPY FOR ANGINA AND DISEASE PREVENTION
    19.
    发明申请
    INTERMITTENT PACING THERAPY FOR ANGINA AND DISEASE PREVENTION 审中-公开
    用于治疗和预防疾病的间歇性治疗

    公开(公告)号：US20100016913A1

    公开(公告)日：2010-01-21

    申请号：US12504602

    申请日：2009-07-16

    申请人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Robert Shipley ,  Jason J. Hamann

    发明人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Robert Shipley ,  Jason J. Hamann

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61N1/3601 ,  A61N1/36528 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/3684

    摘要： A pacing system delivers cardiac protective pacing therapy (CPPT) to protect the heart from injuries and/or to treat existing injuries. The pacing system receives a set of inputs and delivers optimized cardiac protection pacing tailored for each of different purposes. The system delivers electrical stimulation to provide therapy for angina and/or to provide therapy for co-morbidities related to neural imbalance. In one embodiment, a method for treating angina is provided. A signal is sensed indicative of an incidence of angina and an angina region being a myocardial region affected by the angina. The incidence of angina is detected and the angina region is located. A pacing location is selected remote from the angina region, and CPPT is initiated at the pacing location. The CPPT is adapted to create increased stress at the angina region, to promote mass-redistribution and angiogenesis at the angina region to treat the angina.

    摘要翻译： 起搏系统提供心脏保护起搏治疗（CPPT），以保护心脏免受伤害和/或治疗现有的伤害。 起搏系统接收一组输入，并提供针对不同目的量身定制的优化的心脏保护起搏。 该系统提供电刺激以提供心绞痛治疗和/或为与神经不平衡相关的并发症提供治疗。 在一个实施方案中，提供了治疗心绞痛的方法。 感测到的信号指示心绞痛的发生率，心绞痛区域是受心绞痛影响的心肌区域。 发现心绞痛发生，心绞痛区域位于。 从心绞痛区域选择起搏位置，并在起搏位置启动CPPT。 CPPT适应于在心绞痛区域产生增加的压力，以促进心绞痛区域的质量再分配和血管生成以治疗心绞痛。