公开(公告)号：US10167339B2

公开(公告)日：2019-01-01

申请号：US15501526

申请日：2015-08-03

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Yong-Jun Liu ,  Sandra Zurawski ,  SangKon Oh ,  Shino Hanabuchi ,  Haruyuki Fujita ,  Hideki Ueno ,  Patrick Blanco ,  Hyemee Joo

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/28

Abstract: Described herein are methods and compositions for treating autoimmunity and inflammatory conditions without non-specific suppression of the host immune system. In particular, the anti-OX40L antibodies described herein are unique in that they not only inhibit the differentiation of inflammatory T cells but also promote the generation and function of regulatory T cells by inducing IL-10 and inhibiting TNF-α and by reducing aberrant Th2 cell responses. Furthermore, the methods and compositions described herein eliminate or reduce aberrant T follicular helper cell—(Tfh) responses that may contribute to the pathogenicity of autoimmune disease.

公开(公告)号：US20140227268A1

公开(公告)日：2014-08-14

申请号：US14254206

申请日：2014-04-16

Applicant: Baylor Research Institute

Inventor： Jacques F. Banchereau ,  Sangkon Oh ,  Gerard Zurawski ,  Sandra Zurawski ,  Dapeng Li

IPC: C07K16/28 ,  C07K14/435 ,  C07K14/37 ,  C07K14/405 ,  C07K14/005 ,  C07K14/195

CPC classification number: A61K39/145 ,  A61K47/6849 ,  A61K51/1027 ,  A61K2039/5154 ,  C07K14/005 ,  C07K14/195 ,  C07K14/37 ,  C07K14/405 ,  C07K14/435 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/92 ,  C12N5/0639 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  Y02A50/472

Abstract: The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells.

Abstract translation: 本发明包括用于制备和使用可以例如激活DC和其他细胞的抗DC-ASGPR抗体的组合物和方法。

公开(公告)号：US10993990B2

公开(公告)日：2021-05-04

申请号：US15311572

申请日：2015-05-15

Applicant: Baylor Research Institute

Inventor： SangKon Oh ,  Sandra Zurawski ,  Hyemee Joo ,  Gerard Zurawski

IPC: A61K38/20 ,  C07K14/54 ,  A61K39/00 ,  C07K16/28

Abstract: Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.

公开(公告)号：US10980869B2

公开(公告)日：2021-04-20

申请号：US15703685

申请日：2017-09-13

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Peter Klucar ,  Keiko Akagawa ,  Sandra Zurawski ,  SangKon Oh

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/28 ,  C07K14/435

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US20160022792A1

公开(公告)日：2016-01-28

申请号：US14819909

申请日：2015-08-06

Applicant: Baylor Research Institute

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Peter Klucar ,  Keiko Akagawa ,  Sandra Zurawski ,  SangKon Oh

IPC: A61K39/00 ,  C07K14/435 ,  C07K16/28

CPC classification number: A61K39/0011 ,  A61K2039/6056 ,  C07K14/435 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/33 ,  C07K2319/91 ,  Y02A50/39 ,  Y02A50/466

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

Abstract translation: 本发明包括用于表达，分泌和使用用作例如疫苗和抗原递送载体的用于将抗原递送至抗原呈递细胞的组合物和方法。 在一个实施方案中，载体是抗CD40抗体或其片段，以及与抗-CD40抗体或其片段（包括人源化抗体）连接的一个或多个抗原肽。

公开(公告)号：US12214034B2

公开(公告)日：2025-02-04

申请号：US18329696

申请日：2023-06-06

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Sangkon Oh ,  Sandra Zurawski ,  Gerard Zurawski

IPC: A61K39/12 ,  A61K39/395 ,  C07K14/005 ,  C07K14/025 ,  C07K16/28 ,  C12N7/00 ,  A61K39/00

Abstract: Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers.

公开(公告)号：US11267895B2

公开(公告)日：2022-03-08

申请号：US16946302

申请日：2020-06-15

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Jacques F. Banchereau ,  Gerard Zurawski ,  Sandra Zurawski ,  SangKon Oh

IPC: C07K16/28 ,  C07K14/005 ,  A61K39/00

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccine and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US20210024641A1

公开(公告)日：2021-01-28

申请号：US16946302

申请日：2020-06-15

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Jacques F. Banchereau ,  Gerard Zurawski ,  Sandra Zurawski ,  SangKon Oh

IPC: C07K16/28 ,  C07K14/005

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccine and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US10722572B2

公开(公告)日：2020-07-28

申请号：US16708787

申请日：2019-12-10

Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Baylor Research Institute ,  Universite Paris Est Creteil Val De Marne ,  Assistance Publique Hopitaux de Paris

Inventor： Yves Levy ,  Gerard Zurawski ,  Sandra Zurawski ,  Anne-Laure Flamar

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K39/12 ,  A61K39/21 ,  C07K14/005 ,  C12N7/00 ,  C07K16/10 ,  A61P31/18

Abstract: Methods and compositions are provided that can be used to vaccinate against and treat HIV. Specifically contemplated are vaccine compositions and methods of using these compositions treat HIV in patients. Aspects of the disclosure relate to an anti-CD40 antibody-HIV antigen fusion protein comprising (i) an anti-CD40 heavy chain (HCD40)-HIV antigen (Ag) fusion protein comprising the formula: HCD40-Ag, wherein Ag is a polypeptide with at least 80% sequence identity to SEQ ID NO:1; and (ii) an anti-CD40 light chain (LCD40).

公开(公告)号：US20170114142A1

公开(公告)日：2017-04-27

申请号：US15401856

申请日：2017-01-09

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Jacques F. Banchereau ,  Gerard Zurawski ,  Sandra Zurawski ,  SangKon Oh

IPC: C07K16/28

CPC classification number: C07K16/2878 ,  A61K39/00 ,  A61K2039/6056 ,  C07K14/005 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/74 ,  C07K2317/80 ,  C07K2319/00 ,  C12N2740/16222 ,  C12N2740/16322

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccine and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.