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11.发明授权Bicyclic carbohydrates as antiprotozoal bioactive for the treatment of infections caused by parasites 失效双环碳水化合物作为抗原生物活性物质用于治疗由寄生虫引起的感染公开(公告)号：US07125854B2
公开(公告)日：2006-10-24
申请号：US10752792
申请日：2004-01-07
申请人： Benedikt Sas , Johan Van hemel , Jan Vandenkerckhove , Eric Peys , Johan Van der Eycken , Bart Ruttens
发明人： Benedikt Sas , Johan Van hemel , Jan Vandenkerckhove , Eric Peys , Johan Van der Eycken , Bart Ruttens
CPC分类号： C07D493/04
摘要： The use of bicyclic carbohydrates for the treatment of parasite infections is described. Different bicyclic carbohydrates have been tested in vitro against a number of protozoa. These compounds also have been screened against viruses, tumors, bacteria and fungi. Compound A1, a thiophenyl-containing bicyclic carbohydrate possessed significant activity against Trypanosoma brucei rhodiense, a parasite that causes the lethal sleeping sickness. Compound A2 and Compound A3, bicyclic carbohydrates with halogen containing aryl groups, possessed significant activity against Leishmania donovani, a parasite that causes leishmaniasis. Bicyclic carbohydrates in general, and Compound A1, Compound A2 and Compound A3 more specifically, could be possible treatments for the sleeping sickness and leishmaniasis in the future.
摘要翻译： 描述了使用双环碳水化合物治疗寄生虫感染。 已经在体外对许多原生动物测试了不同的双环碳水化合物。 这些化合物也已经针对病毒，肿瘤，细菌和真菌进行了筛选。 化合物A1，含噻吩基的双环碳水化合物对引起致死性昏睡病的寄生虫Brucei rhodiense具有显着的活性。 化合物A2和化合物A3，具有含卤素芳基的双环碳水化合物，对引起利什曼病的寄生虫的利什曼原虫（Leishmania donovani）具有显着的活性。 一般来说，双环碳水化合物，化合物A1，化合物A2和化合物A3更具体地可能是今后睡眠病和利什曼病的治疗方法。
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12.发明申请Use of bacillus amyloliquefaciens PB6 for the prophylaxis or treatment of gastrointestinal and immuno-related diseases 审中-公开使用解淀粉芽孢杆菌PB6用于预防或治疗胃肠道和免疫相关疾病公开(公告)号：US20080057047A1
公开(公告)日：2008-03-06
申请号：US11605736
申请日：2006-11-28
申请人： Benedikt Sas , Johan Van Hemel , Jan Vandenkerckhove , Eric Peys , Hai Tan , Chea-Yun Se , Chanivilparampu Ramchand , Jerry Varghese
发明人： Benedikt Sas , Johan Van Hemel , Jan Vandenkerckhove , Eric Peys , Hai Tan , Chea-Yun Se , Chanivilparampu Ramchand , Jerry Varghese
CPC分类号： A61K35/742 , A23L33/135 , A61K38/164 , C12R1/07 , C12R1/125
摘要： Bacteria of the sp. Bacillus that produce a lipopeptide are found to be effective in the treatment and prophylaxis of gastro-intestinal disease when administered as a probiotic. In particular, a strain of Bacillus bacteria identified as PB6 is useful for the treatment of Antibiotic Associated Diarrhea (AAD) or the more serious condition Clostridium difficile associated diarrhea (CDAD) when administered as a probiotic. Additionally, these bacteria have been found efficient for the treatment of immunorelated diseases such as Inflammatory Bowel Disease (IBD).
摘要翻译： 细菌 发现产生脂肽的芽孢杆菌在作为益生菌施用时可有效地治疗和预防胃肠道疾病。 特别地，当作为益生菌施用时，鉴定为PB6的芽孢杆菌菌株可用于治疗抗生素相关性腹泻（AAD）或更严重的艰难梭菌相关性腹泻（CDAD）。 另外，已经发现这些细菌对于治疗免疫反应性疾病如炎症性肠病（IBD）是有效的。
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13.发明授权Preparation and use of carbohydrate-based bicyclic ring structures with antimicrobial and cytostatic activity 失效基于碳水化合物的双环结构的制备和使用具有抗微生物和细胞生长抑制活性公开(公告)号：US07534871B2
公开(公告)日：2009-05-19
申请号：US10861768
申请日：2004-06-04
申请人： Benedikt Sas , Johan van der Eycken , Johan Van hemel , Petra Blom , Jan Vandenkerckhove , Bart Ruttens
发明人： Benedikt Sas , Johan van der Eycken , Johan Van hemel , Petra Blom , Jan Vandenkerckhove , Bart Ruttens
CPC分类号： C07H15/10 , C07D309/10 , C07D493/04 , C07H7/02 , C07H7/04 , C07H9/04 , C07H15/203
摘要： Novel carbohydrate-based compounds with an attached ring system that have antimicrobial or cytostatic activity. The compounds are administered to humans and animals for the treatment or amelioration of bacterial, fungal, viral or protozoal infections or tumors. The compounds are of the general formula:
摘要翻译： 具有附着环系的新型基于碳水化合物的化合物具有抗微生物或抑制细胞活性。 将化合物施用于人和动物以治疗或改善细菌，真菌，病毒或原生动物感染或肿瘤。 该化合物具有以下通式：
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公开(公告)号：US07138531B2
公开(公告)日：2006-11-21
申请号：US09977478
申请日：2001-10-15
申请人： Benedikt Sas , Johan van der Eycken , Johan Van hemel , Petra Blom , Jan Vandenkerckhove , Bart Ruttens
发明人： Benedikt Sas , Johan van der Eycken , Johan Van hemel , Petra Blom , Jan Vandenkerckhove , Bart Ruttens
IPC分类号： C07D493/04
CPC分类号： C07H15/10 , C07D309/10 , C07D493/04 , C07H7/02 , C07H7/04 , C07H9/04 , C07H15/203
摘要： Novel carbohydrate-based compounds with an attached ring system that have antimicrobial or cytostatic activity. The compounds are administered to humans and animals for the treatment or amelioration of bacterial, fungal, viral or protozoal infections or tumors. The compounds are of the general formula:
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公开(公告)号：US6068997A
公开(公告)日：2000-05-30
申请号：US259603
申请日：1999-03-01
申请人： Benedikt Sas , Eric Peys
发明人： Benedikt Sas , Eric Peys
CPC分类号： C12P7/6445 , C12P13/00
摘要： Conversion of crude lecithin is performed by incubating the lecithin with a lipase-phospholipase mixture in a water/polyol environment. The incubation is carried out at about 40-50.degree. C. and a pH of about 7 to about 8 while stirring continuously. The reaction simultaneously produces lysolipid, lysophospholipid, monoglycerides, and diglycerides. The conversion rate of lecithin is more than 80% based on the ratio of LPC/PC (lysophosphatidylcholine/phosphatidylcholine). Calcium chloride can be added to the reaction mixture to capture released fatty acids.
摘要翻译： 通过在水/多元醇环境中将卵磷脂与脂肪酶 - 磷脂酶混合物孵育来进行粗卵磷脂的转化。 在约40-50℃下进行温育并在约7至约8的pH下连续搅拌。 反应物同时产生溶脂，溶血磷脂，甘油单酯和甘油二酯。 基于LPC / PC（溶血磷脂酰胆碱/磷脂酰胆碱）的比例，卵磷脂的转化率大于80％。 可以将氯化钙加入到反应混合物中以捕获释放的脂肪酸。
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公开(公告)号：US07211281B2
公开(公告)日：2007-05-01
申请号：US09753381
申请日：2001-01-02
申请人： Eddy Van Beek , Ingrid Somers , Eric Peys , Benedikt Sas
发明人： Eddy Van Beek , Ingrid Somers , Eric Peys , Benedikt Sas
CPC分类号： A23K10/14 , A23K20/158 , A23K20/189
摘要： A method for improving the performance of enzymes used in animal feeds by the use of surfactants. Lecithin and/or lysolecithin is added to an animal feed including an exogenous enzyme to boost the performance of the enzyme so that a desired level of performance can be maintained while reducing the amount of exogenous enzyme that must be included in the animal feed. Preferably, the surfactant includes lyso-forms of lecithin.
摘要翻译： 一种通过使用表面活性剂改善动物饲料中所用酶的性能的方法。 将卵磷脂和/或溶血卵磷脂加入到包含外源酶的动物饲料中以增强酶的性能，使得可以在减少必须包括在动物饲料中的外源酶的量的同时保持期望的水平。 优选地，表面活性剂包括卵磷脂的溶解形式。
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17.发明申请INCORPORATION OF THERMO-RESISTANT AND/OR PRESSURE-RESISTANT ORGANISMS IN MATERIALS 审中-公开在材料中加入耐热和/或耐压有机物质公开(公告)号：US20110217758A1
公开(公告)日：2011-09-08
申请号：US13120908
申请日：2009-09-24
申请人： Johan Mertens , Lynda Beladjal , Frank Devlieghere , Sam Verbrugghe , Benedikt Sas , Filip Du Prez , Tom Anthierens , Assia Ouchchen
发明人： Johan Mertens , Lynda Beladjal , Frank Devlieghere , Sam Verbrugghe , Benedikt Sas , Filip Du Prez , Tom Anthierens , Assia Ouchchen
摘要： The present application relates to methods for producing materials having viable micro-organisms incorporated therein. More particularly, the materials are produced under high temperature and/or high pressure conditions, and the microganisms are incorporated in the material before or during these conditions. Also provided are micro-organisms that remain viable under these conditions and have different applications, depending on the nature of the material.
摘要翻译： 本申请涉及用于生产具有并入其中的活微生物的材料的方法。 更具体地说，材料是在高温和/或高压条件下生产的，并且在这些条件之前或期间将微生物并入材料中。 还提供了在这些条件下保持存活并且具有不同应用的微生物，这取决于材料的性质。
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18.发明授权Areno [e]indols, preparation method and application as intermediates in the synthesis of products with antitumoral activity 失效竞争性[e]吲哚，制备方法和应用作为合成具有抗肿瘤活性的产品的中间体
公开(公告)号：US5631384A
公开(公告)日：1997-05-20
申请号：US674863
申请日：1996-07-03
申请人： Koen Alexander , Jose Delamano Garcia , Benedikt Sas , Gabriel Tojo Suarez , Dolores Garcia Gravalos
发明人： Koen Alexander , Jose Delamano Garcia , Benedikt Sas , Gabriel Tojo Suarez , Dolores Garcia Gravalos
IPC分类号： C07D209/58 , C07D207/34 , C07D209/00 , C07D209/60 , C07D487/04 , C07D491/048 , C07D495/04 , C07D487/02 , C07D209/56
CPC分类号： C07D487/04 , C07D209/60
摘要： The compounds (I) are useful as intermediates in the synthesis of hexahydroareno(e)cyclopropa(c)indol-4-ones with antitumoral activity.
摘要翻译： 化合物（I）可用作合成具有抗肿瘤活性的六氢异环（e）环丙烷（c）吲哚-4-酮的中间体。
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19.发明授权Method for alleviating intestinal problems and novel bacterial strains therefor 有权减轻肠道问题及其新型细菌菌株的方法公开(公告)号：US08697052B2
公开(公告)日：2014-04-15
申请号：US13138461
申请日：2010-02-22
申请人： Filip Van Immerseel , Frank Pasmans , Richard Ducatelle , Benedikt Sas , Venessa Eeckhaut , Freddy Haesebrouck
发明人： Filip Van Immerseel , Frank Pasmans , Richard Ducatelle , Benedikt Sas , Venessa Eeckhaut , Freddy Haesebrouck
CPC分类号： C12R1/10 , A23K10/18 , A61K35/741 , C12P7/52
摘要： The present invention relates to butyrate producing bacterial strains related to the species Butyncoccus pullicaecorum to be used in the prevention and/or treatment of intestinal health problems. The present invention therefore provides methods and compositions that overcome the problems associated with the currently used methods for administering butyric acid in the treatment of intestinal health problems in humans and/or animals.
摘要翻译： 本发明涉及用于预防和/或治疗肠道健康问题的与异种芸苔属异虱属相关的丁酸盐生产细菌菌株。 因此，本发明提供了克服与用于治疗人类和/或动物中肠道健康问题的目前使用的丁酸方法相关的问题的方法和组合物。
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20.发明授权公开(公告)号：US06221417B1
公开(公告)日：2001-04-24
申请号：US09193667
申请日：1998-11-17
申请人： Benedikt Sas , Clifford Adams
发明人： Benedikt Sas , Clifford Adams
IPC分类号： A23L127
CPC分类号： C07C403/24 , A23K20/179 , A23K50/75 , C07C29/095 , C07C29/1285 , C07C2601/16 , C07C35/18
摘要： This invention relates to the in situ process for converting non-free-form xanthophylls to free xanthophylls in the biological material of the plant. The method, more particularly, relates to a method that would liberate xanthophylls by transesterification of acyl-xanthophylls in plant materials which is used as a natural food colorant.
摘要翻译： 本发明涉及在植物的生物材料中将非自由形式的叶黄素转化为游离的叶黄素的原位方法。 更具体地说，该方法涉及通过酰基叶黄素在用作天然食品着色剂的植物材料中进行酯交换而释放叶黄素的方法。
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