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    Separating motion from cardiac signals using second order derivative of the photo-plethysmogram and fast fourier transforms
    13.
    发明授权
    Separating motion from cardiac signals using second order derivative of the photo-plethysmogram and fast fourier transforms 有权

    公开(公告)号：US07020507B2

    公开(公告)日：2006-03-28

    申请号：US10356697

    申请日：2003-01-30

    申请人： John E. Scharf ,  Bhavin Shah

    发明人： John E. Scharf ,  Bhavin Shah

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14551 ,  A61B5/7207 ,  A61B5/7239 ,  A61B5/7253 ,  A61B5/7257 ,  A61B5/726

    摘要： The present invention is directed toward a pulse oximetry system for the determination of a physiological parameter capable of removing motion artifacts from physiological signals comprises a hardware subsystem and a software subsystem. The software subsystem is used in conjunction with the hardware subsystem to perform a method for removing a plurality of motion artifacts from the photo-plethysmographic data and for obtaining a measure of at least one physiological parameter from the data. The method comprises acquiring the raw photo-plethysmographic data, transforming the data into the frequency domain, analyzing the transformed data to locate a series of candidate cardiac spectral peaks (primary plus harmonics), reconstructing a photo-plethysmographic signal in the time domain with only the candidate cardiac spectral peaks (primary plus harmonics), computing the second order derivative of the reconstructed photo-plethysmographic signal, analyzing the candidate second order derivative photo-plethysmographic signal to determine the absence or presence of cardiac physiologic signal characteristics, and finally selecting the best physiologic candidate from the series of potential cardiac spectral peaks (primary plus harmonics) based upon a second derivative scoring system. This scoring system is preferentially based upon second derivative processing analysis, but can be equally applied using the first, third, fourth or other similar derivative processing analysis.

    Medical products including modified extracellular matrix materials
    14.
    发明授权
    Medical products including modified extracellular matrix materials 有权
    医疗产品包括修饰细胞外基质材料

    公开(公告)号：US08557277B2

    公开(公告)日：2013-10-15

    申请号：US12780271

    申请日：2010-05-14

    申请人： Joel A. Virkler ,  Lal Ninan ,  Bhavin Shah

    发明人： Joel A. Virkler ,  Lal Ninan ,  Bhavin Shah

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61F13/00

    CPC分类号： A61L27/365 ,  A61L27/3604 ,  A61L27/3633 ,  A61L27/3687 ,  A61L27/54 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/608 ,  A61L2430/40

    摘要： Described, in certain aspects, are medical products comprised of uniquely prepared remodelable extracellular matrix (ECM) materials retaining at least a portion of their native bioactivity. Also described are methods for forming and using such products. In one embodiment, an inventive product comprises a layer of remodelable ECM material modified through contact with periodic acid or a salt thereof. In some forms, such a modified ECM material layer includes non-native Schiff's base crosslinks within and/or between certain components of the ECM material (e.g., between two collagen molecules, two non-collagen molecules, and/or a collagen molecule and a non-collagen molecule). Other inventive products are comprised of various gels, foams, pastes, and formed, coherent, porous bodies at least containing ECM materials that have been modified in accordance with the present invention.

    摘要翻译： 在某些方面描述了由保留其天然生物活性的至少一部分的独特制备的可重塑细胞外基质（ECM）材料组成的医疗产品。 还描述了形成和使用这些产品的方法。 在一个实施方案中，本发明的产品包含通过与高碘酸或其盐接触而改性的可重塑ECM材料层。 在某些形式中，这种修饰的ECM材料层包括在ECM材料的某些组分之内和/或之间的非天然Schiff碱基交联（例如，两个胶原分子，两个非胶原分子和/或胶原分子和/ 非胶原分子）。 其他发明产品由各种凝胶，泡沫，糊剂和形成的，粘结的多孔体组成，至少含有根据本发明进行了改性的ECM材料。

    Tissue augmentation devices and methods
    15.
    发明授权
    Tissue augmentation devices and methods 有权
    组织增强装置和方法

    公开(公告)号：US08470356B2

    公开(公告)日：2013-06-25

    申请号：US12939636

    申请日：2010-11-04

    申请人： Umesh H. Patel ,  F. Joseph Obermiller ,  Bhavin Shah ,  Chad E. Johnson

    发明人： Umesh H. Patel ,  F. Joseph Obermiller ,  Bhavin Shah ,  Chad E. Johnson

    IPC分类号： A61M5/158 ,  C12N5/00 ,  A61F2/00 ,  A61M31/00 ,  A61M5/178 ,  A61B17/34 ,  A61B17/04 ,  A61B17/06 ,  C12M1/00

    CPC分类号： A61F2/0059

    摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.

    摘要翻译： 公开了组织增加装置，以及制造和使用它们的方法。 在某些实施例中，组织增强装置包括细长的组织穿透构件和一定量的可重塑材料，其中细长构件的至少一部分被插管，并且至少部分材料量被容纳在至少一部分内 的细长构件的插管部分。 细长组织穿透构件可以提供至少一个变形，其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。 在替代实施例中，可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。

    MEDICAL REINFORCEMENT GRAFT
    16.
    发明申请
    MEDICAL REINFORCEMENT GRAFT 失效
    医用加强筋

    公开(公告)号：US20110077455A1

    公开(公告)日：2011-03-31

    申请号：US12892123

    申请日：2010-09-28

    申请人： Mark Duncan ,  Christopher M. Nelson ,  F. Joseph Obermiller ,  Bhavin Shah

    发明人： Mark Duncan ,  Christopher M. Nelson ,  F. Joseph Obermiller ,  Bhavin Shah

    IPC分类号： A61F2/04

    CPC分类号： A61F2/0036 ,  A61B17/04 ,  A61B17/06

    摘要： The embodiments described include graft devices for reinforcing patient tissue structures and methods of making and using the graft devices. In certain embodiments the graft devices have a remodelable extracellular matrix material graft body defining a slot and having a portion receivable through the slot to form a closed loop. Such graft devices can be used in encircling reinforcement of patient tissue structures such as anal sphincters or anastomosed vessel segments.

    摘要翻译： 所描述的实施例包括用于加强患者组织结构的移植装置以及制造和使用移植装置的方法。 在某些实施方案中，移植装置具有限定狭缝的可重塑的细胞外基质材料移植物主体，并具有通过狭槽可接收部分以形成闭合环。 这种移植装置可以用于围绕加强患者组织结构，例如肛门括约肌或吻合血管段。

    Tissue augmentation devices and methods
    17.
    发明授权
    Tissue augmentation devices and methods 有权
    组织增强装置和方法

    公开(公告)号：US07850985B2

    公开(公告)日：2010-12-14

    申请号：US11481422

    申请日：2006-07-05

    申请人： Umesh H. Patel ,  F. Joseph Obermiller ,  Bhavin Shah ,  Chad E. Johnson

    发明人： Umesh H. Patel ,  F. Joseph Obermiller ,  Bhavin Shah ,  Chad E. Johnson

    IPC分类号： A61M5/158 ,  A61F2/00 ,  C12N5/00 ,  A61M5/178 ,  A61M31/00 ,  C12M1/00 ,  A61B17/34 ,  A61B17/04 ,  A61B17/06

    CPC分类号： A61F2/0059

    摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.

    摘要翻译： 公开了组织增加装置，以及制造和使用它们的方法。 在某些实施例中，组织增强装置包括细长的组织穿透构件和一定量的可重塑材料，其中细长构件的至少一部分被插管，并且至少部分材料量被容纳在至少一部分内 的细长构件的插管部分。 细长组织穿透构件可以提供至少一个变形，其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。 在替代实施例中，可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。

    TISSUE AUGMENTATION DEVICES AND METHODS
    18.
    发明申请
    TISSUE AUGMENTATION DEVICES AND METHODS 有权
    组织补充装置及方法

    公开(公告)号：US20080248079A1

    公开(公告)日：2008-10-09

    申请号：US12114456

    申请日：2008-05-02

    申请人： Ryan Dempsey ,  Jeffrey Miller ,  Steve Chen ,  Umesh H. Patel ,  F. Joseph Obermiller ,  Bhavin Shah ,  Chad E. Johnson

    发明人： Ryan Dempsey ,  Jeffrey Miller ,  Steve Chen ,  Umesh H. Patel ,  F. Joseph Obermiller ,  Bhavin Shah ,  Chad E. Johnson

    IPC分类号： A61F2/00 ,  A61M31/00

    CPC分类号： A61F2/0059 ,  A61B17/06004 ,  A61B2017/06052 ,  A61F2/02 ,  A61L27/24 ,  A61M5/32 ,  A61M25/0662 ,  A61M2025/018 ,  Y10S623/915

    摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.

    摘要翻译： 公开了组织增加装置，以及制造和使用它们的方法。 在某些实施例中，组织增强装置包括细长的组织穿透构件和一定量的可重塑材料，其中细长构件的至少一部分被插管，并且至少部分材料量被容纳在至少一部分内 的细长构件的插管部分。 细长组织穿透构件可以提供至少一个变形，其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。 在替代实施例中，可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。

    MEDICAL DEVICES AND METHODS USEFUL FOR APPLYING BOLSTER MATERIAL
    19.
    发明申请
    MEDICAL DEVICES AND METHODS USEFUL FOR APPLYING BOLSTER MATERIAL 有权
    医疗装置和应用于BOLSTER材料的方法

    公开(公告)号：US20080200949A1

    公开(公告)日：2008-08-21

    申请号：US12110006

    申请日：2008-04-25

    申请人： Michael C. Hiles ,  Umesh H. Patel ,  Bhavin Shah ,  Chad S. McAlexander

    发明人： Michael C. Hiles ,  Umesh H. Patel ,  Bhavin Shah ,  Chad S. McAlexander

    IPC分类号： A61B17/08

    CPC分类号： A61B17/07292 ,  A61B17/00491 ,  A61B17/0643 ,  A61B17/0644 ,  A61B17/072 ,  A61B17/07207 ,  A61B50/20 ,  A61B2017/00884 ,  A61B2090/037

    摘要： Described are medical devices useful for applying a bolster material to a surgical fastening device such as a stapler, and related methods of manufacture and use. The devices include an applicator element for receipt between arms of the stapler, and a bolster material, desirably a remodelable extracellular matrix material, coupled to the applicator element. In certain embodiments, the bolster material is held by the applicator element, for example having at least a portion looped around or received through or over a portion of the applicator element. Also described are unique implantable materials including coatings of dried, reversible adhesive.

    摘要翻译： 描述了可用于将枕头材料应用于诸如吻合器的外科紧固装置的医疗装置，以及相关的制造和使用方法。 这些装置包括用于在吻合器的臂之间接收的施加器元件和耦合到施加器元件的垫片材料，期望地是可重塑的细胞外基质材料。 在某些实施例中，枕垫材料被施用器元件保持，例如具有至少部分环绕或接收通过施加器元件的一部分的部分。 还描述了独特的可植入材料，包括干燥的可逆粘合剂的涂层。