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公开(公告)号：US20210401874A1
公开(公告)日：2021-12-30
申请号：US17341912
申请日：2021-06-08
Applicant: CytoSorbents Corporation
Inventor： Thomas Golobish , Maryann Gruda , Tamaz Guliashvili , Pamela O'Sullivan , Andrew Scheirer , Vi Dan , Wei-Tai Young , Vincent Capponi , Phillip Chan
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
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公开(公告)号：US20210330697A1
公开(公告)日：2021-10-28
申请号：US17229265
申请日：2021-04-13
Applicant: CytoSorbents Corporation
Inventor： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Humayra Begum Ali
IPC: A61K31/745 , A61K31/74 , A61K31/75 , A61K9/00 , A61K9/16 , A61K9/50 , B01J20/26 , B01J20/28 , B01J20/30 , C08F212/36 , C08J9/26 , A61K47/58
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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13.发明授权公开(公告)号：US11065600B2
公开(公告)日：2021-07-20
申请号：US16303232
申请日：2017-05-18
Applicant: CYTOSORBENTS CORPORATION
Inventor： Tamaz Guliashvili , Thomas Golobish , Maryann Gruda , Pamela O'Sullivan , Andrew Scheirer , Vincent Capponi , Phillip Chan , Wei-Tai Young
IPC: A61K31/745 , B01J20/00 , B01J20/26 , B01D15/34 , B01J20/28 , B01J20/32 , A61K9/00 , A61M1/36 , B01D15/12
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
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公开(公告)号：US20190282608A1
公开(公告)日：2019-09-19
申请号：US16424747
申请日：2019-05-29
Applicant: Cytosorbents Corporation
Inventor： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Humayra Begum Ali
IPC: A61K31/745 , A61K47/58 , A61K31/75 , A61K9/00 , C08J9/26 , C08F212/36 , B01J20/28 , A61K9/16 , B01J20/26 , B01J20/30 , A61K31/74 , A61K9/50
Abstract: The present invention concerns methods of administering a therapeutically effective dose of a sorbent for an inflammatory mediator to a patient where the inflammatory mediator is one or more of enzymes, cytokines, prostaglandins, eicosanoids, leukotrienes, kinins, complement, coagulation factors, endotoxins, enterotoxins, lipopolysaccharide, cell fragments, bile salts, fatty acids, phospholipids, interferon and immunomodulatory antibodies, biologics or drugs.
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公开(公告)号：US10034894B2
公开(公告)日：2018-07-31
申请号：US15635517
申请日：2017-06-28
Applicant: CytoSorbents Corporation
Inventor： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Humayra Begum Ali
IPC: A61K31/745 , A61K9/16 , A61K9/50 , C08J9/26 , B01J20/26 , B01J20/30 , A61K9/00 , B01J20/28 , C08F212/36 , A61K31/74 , A61K31/75 , A61K47/58
CPC classification number: A61K31/745 , A61K9/0053 , A61K9/16 , A61K9/50 , A61K31/74 , A61K31/75 , A61K47/58 , B01J20/261 , B01J20/28004 , B01J20/28073 , B01J20/28076 , B01J20/3064 , C08F212/36 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2325/02 , Y02A50/406 , Y02A50/411
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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Patent Agency Ranking
公开(公告)号：US20170296574A1
公开(公告)日：2017-10-19
申请号：US15635517
申请日：2017-06-28
Applicant: CytoSorbents Corporation
Inventor： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Humayra Begum Ali
IPC: A61K31/745 , A61K9/16 , A61K9/50 , C08J9/26 , B01J20/26 , B01J20/30 , A61K9/00 , B01J20/28 , C08F212/36
CPC classification number: A61K31/745 , A61K9/0053 , A61K9/16 , A61K9/50 , A61K31/74 , A61K31/75 , A61K47/58 , B01J20/261 , B01J20/28004 , B01J20/28073 , B01J20/28076 , B01J20/3064 , C08F212/36 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2325/02 , Y02A50/406 , Y02A50/411
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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公开(公告)号：US11723916B2
公开(公告)日：2023-08-15
申请号：US17341912
申请日：2021-06-08
Applicant: CytoSorbents Corporation
Inventor： Thomas Golobish , Maryann Gruda , Tamaz Guliashvili , Pamela O'Sullivan , Andrew Scheirer , Vi Dan , Wei-Tai Young , Vincent Capponi , Phillip Chan
IPC: A61K31/795 , A61M5/165 , B01J20/26 , B01J39/20 , B01J20/28 , A61K47/20 , A61K47/26 , A61M1/36 , A61M5/14
CPC classification number: A61K31/795 , A61K47/20 , A61K47/26 , A61M5/165 , B01J20/264 , B01J20/267 , B01J20/28069 , B01J39/20 , A61M1/3679 , A61M5/14
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
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公开(公告)号：US11202855B2
公开(公告)日：2021-12-21
申请号：US16497982
申请日：2018-03-22
Applicant: CYTOSORBENTS CORPORATION
Inventor： Wei-Tai Young , Tamaz Guliashvili , Andrew Scheirer , Josh Vichare , Timothy Kovacs , Maryann Gruda , Thomas Golobish , Vincent Capponi , Phillip Chan
Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.
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公开(公告)号：US10967001B2
公开(公告)日：2021-04-06
申请号：US16018603
申请日：2018-06-26
Applicant: CytoSorbents Corporation
Inventor： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Humayra Begum Ali
IPC: A61K31/745 , A61K31/74 , A61K31/75 , A61K9/00 , A61K9/16 , A61K9/50 , B01J20/26 , B01J20/28 , B01J20/30 , C08F212/36 , C08J9/26 , A61K47/58
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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公开(公告)号：US20180311273A1
公开(公告)日：2018-11-01
申请号：US16018603
申请日：2018-06-26
Applicant: CytoSorbents Corporation
Inventor： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Humayra Begum Ali
IPC: A61K31/745 , A61K31/74 , B01J20/28 , A61K9/16 , B01J20/26 , B01J20/30 , A61K9/50 , C08F212/36 , C08J9/26 , A61K9/00 , A61K31/75
CPC classification number: A61K31/745 , A61K9/0053 , A61K9/16 , A61K9/50 , A61K31/74 , A61K31/75 , A61K47/58 , B01J20/261 , B01J20/28004 , B01J20/28073 , B01J20/28076 , B01J20/3064 , C08F212/36 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2325/02 , Y02A50/406 , Y02A50/411
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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