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11.发明申请USE OF OUTER MEMBRANE PORIN K36 PROTEIN (OMPK36) IN TREATMENT/PREVENTION/DIAGNOSIS OF ENTEROBACTERIACEAE INFECTION 审中-公开使用外膜蛋白K36蛋白（OMPK36）治疗/预防/诊断肠杆菌感染公开(公告)号：US20130251748A1
公开(公告)日：2013-09-26
申请号：US13545492
申请日：2012-07-10
申请人： Leung-Kei Siu , Feng-Yee Chang , Yung-Chung Lin , Chang-Phone Fung , Yip-Mei Liu , Jiun-Han Chen , Yu-Kuo Tsai , Pele Choi-Sing Chong , Chih-Hsiang Leng , Shih-Jen Liu , Hsin-Wei Chen
发明人： Leung-Kei Siu , Feng-Yee Chang , Yung-Chung Lin , Chang-Phone Fung , Yip-Mei Liu , Jiun-Han Chen , Yu-Kuo Tsai , Pele Choi-Sing Chong , Chih-Hsiang Leng , Shih-Jen Liu , Hsin-Wei Chen
IPC分类号： A61K39/108 , A61P31/04 , G01N21/76 , A61K39/112 , G01N33/569 , G01N21/64
CPC分类号： G01N33/56916 , A61K39/0266 , A61K2039/545 , A61K2039/55566 , G01N2333/245 , G01N2333/255 , G01N2333/26 , Y02A50/484 , Y02A50/59
摘要： The present invention relates a method for vaccinating a mammal to produce an antibody against Enterobacteriaceae infection caused by Klebsiella pneumoniae, Salmonella typhi, or E. coli in central nervous system and/or peripheral blood circulation, which comprises administering an effective amount of an OmpK36/homologues or its derivatives to the mammal.
摘要翻译： 本发明涉及一种疫苗接种哺乳动物以产生针对中枢神经系统和/或外周血循环中由肺炎克雷伯杆菌，伤寒沙门氏菌或大肠杆菌引起的肠杆菌科感染的抗体的方法，其包括给予有效量的OmpK36 / 同源物或其衍生物给哺乳动物。
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公开(公告)号：US08466259B2
公开(公告)日：2013-06-18
申请号：US12702567
申请日：2010-02-09
申请人： Shih-Jen Liu , Hsueh-Hung Liu , Chih-Hsiang Leng , Hsin-Wei Chen , Yan Chak Kwok , Pele Choi-Sing Chong
发明人： Shih-Jen Liu , Hsueh-Hung Liu , Chih-Hsiang Leng , Hsin-Wei Chen , Yan Chak Kwok , Pele Choi-Sing Chong
CPC分类号： C07K14/195 , C07K14/22 , C12P21/02
摘要： Disclosed are lipopeptides or lipoproteins, related compositions, and related methods.
摘要翻译： 公开了脂肽或脂蛋白，相关组合物和相关方法。
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公开(公告)号：US08426163B2
公开(公告)日：2013-04-23
申请号：US12329026
申请日：2008-12-05
IPC分类号： C12P21/06
CPC分类号： C12P21/02 , C07K14/195
摘要： Production of a lipidated protein in an E. coli strain adapted to membrane protein expression.
摘要翻译： 在适于膜蛋白表达的大肠杆菌菌株中生产脂质化蛋白。
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14.发明申请Immunogenic Peptides of Tumor Associated Antigen L6 and Uses Thereof in Cancer Therapy 有权肿瘤相关抗原L6及其用途的免疫原性肽在癌症治疗中的应用公开(公告)号：US20110038894A1
公开(公告)日：2011-02-17
申请号：US12846092
申请日：2010-07-29
IPC分类号： A61K39/00 , C07K14/47 , C07K7/08 , C07K7/06 , C07K5/10 , C07K5/08 , A61P35/00 , C07H21/04 , C07K16/30
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/55566
摘要： An immunopeptide containing a T cell epitope from the tumor associated antigen L6 (TAL6) and a nucleic acid encoding the immunopeptide. The immunopeptide and its encoding nucleic acid can be used as a component of an immune composition for enhancing immune response against cancer cells that express TAL6.
摘要翻译： 含有来自肿瘤相关抗原L6（TAL6）的T细胞表位的免疫肽和编码免疫肽的核酸。 免疫肽及其编码核酸可用作免疫组合物的组分，用于增强对表达TAL6的癌细胞的免疫应答。
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公开(公告)号：US20100166785A1
公开(公告)日：2010-07-01
申请号：US12702567
申请日：2010-02-09
申请人： Shih-Jen Liu , Hsueh-Hung Liu , Chih-Hsiang Leng , Hsin-Wei Chen , Yan Chak Kwok , Pele Choi-Sing Chong
发明人： Shih-Jen Liu , Hsueh-Hung Liu , Chih-Hsiang Leng , Hsin-Wei Chen , Yan Chak Kwok , Pele Choi-Sing Chong
IPC分类号： A61K39/00 , A61K38/16 , A61K38/10 , A61K38/08 , A61K38/07 , A61K38/06 , A61K38/05 , A61P31/00 , A61P35/00 , C07C69/00 , C12P21/00
CPC分类号： C07K14/195 , C07K14/22 , C12P21/02
摘要： Disclosed are lipopeptides or lipoproteins, related compositions, and related methods.
摘要翻译： 公开了脂肽或脂蛋白，相关组合物和相关方法。
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16.发明授权公开(公告)号：US08658176B2
公开(公告)日：2014-02-25
申请号：US12820264
申请日：2010-06-22
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/0011 , A61K39/12 , A61K2039/55516 , A61K2039/585 , A61K2039/6018 , C07K14/005 , C07K2319/915 , C12N7/00 , C12N2710/20022 , C12N2710/20034
摘要： Disclosed are polypeptides and fusion proteins. Also disclosed are related immunotherapeutic compositions and methods.
摘要翻译： 披露的是多肽和融合蛋白。 还公开了相关的免疫治疗组合物和方法。
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公开(公告)号：US20120121628A1
公开(公告)日：2012-05-17
申请号：US13296617
申请日：2011-11-15
申请人： Chih-Hsiang Leng , Chi-Ling Tseng , Hsueh-Hung Liu , Shih-Jen Liu , Hsin-Wei Chen , Pele Choi-Sing Chong
发明人： Chih-Hsiang Leng , Chi-Ling Tseng , Hsueh-Hung Liu , Shih-Jen Liu , Hsin-Wei Chen , Pele Choi-Sing Chong
IPC分类号： A61K39/12 , A61P37/04 , C12P21/02 , C07K14/025 , A61P31/20
CPC分类号： A61K39/12 , A61K2039/572 , A61K2039/6018 , A61K2039/70 , C07K14/005 , C12N2710/20022 , C12N2710/20034 , C12P21/02
摘要： This invention relates to, inter alia, an isolated lipidated polypeptide including a lipid moiety at the N-terminus and a plurality of epitopes, and methods of making and using the polypeptide.
摘要翻译： 本发明尤其涉及包含N-末端的脂质部分和多个表位的分离的脂化多肽，以及制备和使用该多肽的方法。
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公开(公告)号：US20110052633A1
公开(公告)日：2011-03-03
申请号：US12553086
申请日：2009-09-02
IPC分类号： A61K39/145 , A61K8/86
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5252 , A61K2039/55555 , A61K2039/55566 , C08G63/06 , C08G63/664 , C12N2760/16134 , Y10S514/937 , Y10S514/938
摘要： An composition comprises (a) a continuous aqueous phase; (b) an oily phase; and (c) an amphiphilic emulsifying system comprising a block copolymer having the formula (A)p-(B)q-(C)r, in which (B)q is a hydrophilic block and (C)r is a hydrophobic block; wherein p, q and r are integers with the proviso that: if p is 0, then A is other than hydroxyl or reactive functional groups and the block copolymer is a diblock copolymer; B and C are each individual repeating) units; if p is >1, then the block copolymer is a triblock copolymer, in which (A)p is a hydrophobic block; the hydrophobic blocks (A)p and (C)r are each homopolymers or heteropolymers; the repeating units A and C are the same or different; and wherein the ratio q/(p+r) is sufficient high so that the hydrophilic-lipophilic balance value of the block copolymer is >10.
摘要翻译： 组合物包含（a）连续水相; （b）油相; 和（c）包含具有式（A）对 - （B）q-（C）r的嵌段共聚物的两亲乳化体系，其中（B）q是亲水性嵌段，（C）r是疏水性嵌段; 其中p，q和r是整数，条件是：如果p是0，则A不是羟基或反应性官能团，并且嵌段共聚物是二嵌段共聚物; B和C各自单独重复）单位; 如果p> 1，则嵌段共聚物是三嵌段共聚物，其中（A）p是疏水嵌段; 疏水嵌段（A）p和（C）r均为均聚物或杂聚物; 重复单元A和C相同或不同; 并且其中q /（p + r）的比例足够高，使得嵌段共聚物的亲水 - 亲油平衡值> 10。
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19.发明申请Lipidating Sequences and Use thereof for Producing Lipidated Proteins in E. Coli 有权脂质化序列及其在大肠杆菌中产生脂质化蛋白的应用公开(公告)号：US20090221499A1
公开(公告)日：2009-09-03
申请号：US12331576
申请日：2008-12-10
CPC分类号： C07K14/22 , A61K38/00 , A61K2039/6018 , C07K14/005 , C07K2319/00 , C07K2319/90 , C12N2770/24122
摘要： Production in E. coli of a lipidated fusion protein containing a lipidating sequence derived from Ag473 and a target polypeptide.
摘要翻译： 在大肠杆菌中生产含有源自Ag473的脂化序列和靶多肽的脂质化融合蛋白。
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20.发明授权Consensus dengue virus envelope protein domain III polypeptides (cED III) and their methods of use 有权共识登革热病毒包膜蛋白III区多肽（cED III）及其使用方法公开(公告)号：US07981431B2
公开(公告)日：2011-07-19
申请号：US12156908
申请日：2008-06-04
CPC分类号： G01N33/56983 , A61K38/00 , A61K39/12 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , G01N2333/185 , G01N2469/10 , G01N2469/20 , Y02A50/386 , Y02A50/53
摘要： A consensus peptide sequence designed for domain III of the envelope proteins of four serotypes of dengue virus and used in a vaccine against multiple serotypes of dengue virus is disclosed. The vaccine is able to elicit cross-neutralization antibody responses against multiple serotypes of dengue virus.
摘要翻译： 公开了针对登革热病毒四种血清型的包膜蛋白的结构域III设计的共用肽序列，并用于针对多种血清型登革病毒的疫苗。 该疫苗能够引发针对多种登革热病毒血清型的交叉中和抗体反应。
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