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11.发明授权Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权角膜玻璃化，产生角膜玻璃化的方法和装置及其使用方法公开(公告)号：US09526656B2
公开(公告)日：2016-12-27
申请号：US14674992
申请日：2015-03-31
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的照相玻璃化系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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公开(公告)号：US06876689B2
公开(公告)日：2005-04-05
申请号：US09876678
申请日：2001-06-07
CPC分类号： H01S3/10092 , H01S3/083 , H01S3/109 , H01S3/1633 , H01S3/1636 , H01S3/1648 , H01S5/12
摘要： A tunable solid-state laser system whose bandwidth and wavelength are controlled by the injection of light from a semiconductor diode laser. This laser system is capable of providing output light pulses over substantially all wavelength ranges in the electromagnetic spectrum. When suitably configured, it creates wavelength tunable (or fixed wavelength) pulses having spectral bandwidths that are Fourier transform limited and wavelength stabilized. The coupling means between the semiconductor diode laser and the ring laser cavity incorporates a means for optically isolating the diode laser source from optical feedback from the ring laser, ensuring diode laser source stability.
摘要翻译： 一种可调谐固态激光系统，其带宽和波长通过从半导体二极管激光器的光注入来控制。 该激光系统能够在电磁光谱中的基本上所有波长范围上提供输出光脉冲。 当适当配置时，它产生波长可调谐（或固定波长）脉冲，其具有被傅里叶变换限制和波长稳定的频谱带宽。 半导体二极管激光器和环形激光腔之间的耦合装置包括用于将二极管激光源与环形激光器的光学反馈光学隔离的装置，确保二极管激光源的稳定性。
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公开(公告)号：US4350577A
公开(公告)日：1982-09-21
申请号：US93659
申请日：1979-11-13
申请人： Donald F. Heller
发明人： Donald F. Heller
CPC分类号： B01D59/34
摘要： Electronic excitation of polyatomic molecules followed by nonradiative decay provides states from which efficient multiphoton infrared excitation can be achieved. Initial (electronic) excitation can be molecule-specific or isotope-selective. Subsequent multiphoton excitation has a threshold which can be an order of magnitude or more lower than for multiphoton excitation from the ground state. By this method, laser-induced chemical reactions or isotope separation can be achieved with lower infrared laser fluence and/or higher concentration of polyatomic molecules than with prior art methods.
摘要翻译： 多原子分子的电子激发随后是非辐射衰减，提供可以实现有效的多光子红外激发的状态。 初始（电子）激发可以是分子特异性或同位素选择性的。 随后的多光子激发具有的阈值可以比来自基态的多光子激发低一个数量级或更多。 通过这种方法，与现有技术方法相比，激光诱导的化学反应或同位素分离可以用较低的红外激光注量和/或更高浓度的多原子分子来实现。
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14.发明申请公开(公告)号：US20190060056A1
公开(公告)日：2019-02-28
申请号：US15693208
申请日：2017-08-31
IPC分类号： A61F2/16
摘要： Devices and methods for novel retinal irradiance distribution modification (IDM) to improve, stabilize or restore vision are described herein. Also encompassed herein are devices and methods to reduce vision loss from diseases, injuries and disorders that involve damaged and/or dysfunctional and/or sensorily deprived retinal cells. Conditions that may be treated using devices and methods described herein include macular degeneration, diabetic retinopathy and glaucoma. Therapy provided by retinal IDM devices and methods described herein may also be used in combination with other therapies including, but not limited to, pharmacological, retinal laser, gene and stem cell therapies.
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15.发明申请CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF 有权角膜修复，生产角膜修复的方法和装置及其使用方法公开(公告)号：US20150230985A1
公开(公告)日：2015-08-20
申请号：US14674992
申请日：2015-03-31
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的照相玻璃化系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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16.发明申请CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF 有权角膜修复，生产角膜修复的方法和装置及其使用方法公开(公告)号：US20150230979A1
公开(公告)日：2015-08-20
申请号：US14674890
申请日：2015-03-31
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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公开(公告)号：US5496306A
公开(公告)日：1996-03-05
申请号：US982022
申请日：1992-11-24
CPC分类号： A61B18/26 , A61B2017/0019
摘要： A method of laser lithotripsy is disclosed that utilizes pulse stretched Q-switched solid state lasers in conjunction with relatively small diameter optical fibers to achieve effective breakup of calculi located within the body, such as kidney and gall stones.
摘要翻译： 公开了一种激光碎石术的方法，其利用脉冲拉伸Q开关固体激光器与相对小直径的光纤结合，以实现位于体内的结石（例如肾和胆结石）的有效分解。
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公开(公告)号：US4713820A
公开(公告)日：1987-12-15
申请号：US762100
申请日：1985-08-02
CPC分类号： H01S3/16 , C30B15/00 , C30B29/10 , C30B29/60 , H01S3/08072 , H01S3/1665
摘要： A single crystal of rare-earth-doped lanthanum beryllate, whose crystal orientation is suitably chosen, provides a laser medium whose index of refraction is substantially independent of temperature. A laser using such a crystal as the laser medium displays little or no thermal lensing, thus permitting high power operation without wavefront distortion.
摘要翻译： 稀土掺杂的镧铍单晶，其晶体取向适当选择，提供了一种激光介质，其折射率基本上与温度无关。 使用像激光介质这样的晶体的激光器显示很少或没有热透镜，从而允许高功率操作而没有波前失真。
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19.发明申请CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF 有权角膜修复，生产角膜修复的方法和装置及其使用方法公开(公告)号：US20150133901A1
公开(公告)日：2015-05-14
申请号：US14512952
申请日：2014-10-13
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased eletastic modulus; methods for producing and using the new composition of matter for modifying cortical structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织在结构和性质上从其天然存在的状态改变成非天然存在的玻璃样状态，其中包括但不限于增加的电化学模量; 用于生产和使用新的组合物用于改变皮层结构和性质的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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20.发明授权
公开(公告)号：US5606453A
公开(公告)日：1997-02-25
申请号：US49955
申请日：1993-04-20
CPC分类号： G02F1/39 , G02F2001/392
摘要： Tunable optical parametric amplifiers and oscillators that are pumped by the light from a tunable laser source are disclosed. One possible embodiment uses a tunable solid-state laser pump and an OPA medium or nonlinear crystal, such as potassium titanyl phosphate KTP or barium borate BBO or lithium borate LBO. The second harmonic output from a tunable solid-state laser is also used to pump the OPA medium. A singly or doubly resonant cavity design is preferably used to reduce the oscillation threshold (i.e., the required pump beam power) of the OPO.
摘要翻译： 公开了可调光学参量放大器和由可调谐激光源的光泵浦的振荡器。 一个可能的实施例使用可调谐固态激光泵和OPA介质或非线性晶体，例如磷酸钾钾KTP或硼酸钡BBO或硼酸锂LBO。 来自可调谐固态激光器的二次谐波输出也用于泵浦OPA介质。 优选使用单或双谐振腔设计来减少OPO的振荡阈值（即，所需的泵浦光束功率）。
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