公开(公告)号：US20230096792A1

公开(公告)日：2023-03-30

申请号：US17908659

申请日：2021-03-02

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Don W. ARNOLD ,  Thomas R. COVEY ,  Chang LIU

IPC: B01L3/00 ,  B03C1/033 ,  B03C1/30

Abstract: An electromagnetic sampling device is disclosed, which comprises a needle having a hollow housing that extends from a proximal end to a distal end, and an electromagnet comprising an electromagnetic coil and a metal core, at least a portion of said metal core extending through said hollow housing of the needle and be configured to transition between an extended position in which the distal end of the metal core extends beyond the distal end of the needle's hollow housing and a retracted position in which the distal end of the metal core is positioned within the needle's housing, wherein an activation of said electromagnetic coil magnetizes the metal core.

公开(公告)号：US20240339311A1

公开(公告)日：2024-10-10

申请号：US18294386

申请日：2022-08-05

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. COVEY ,  David Michael COX ,  Michael JARVIS ,  Chang LIU

IPC: H01J49/00 ,  H01J49/16

CPC classification number: H01J49/0031 ,  H01J49/165

Abstract: A method for measuring a concentration of an analyte in a sample includes: sampling, from a first sample, a first one or more droplets for mass analysis, wherein the first sample includes the sample; performing mass analysis on the first one or more droplets to determine a first intensity of an analyte in the first one or more droplets; sampling, from a second sample, a second one or more droplets for mass analysis, wherein the sec-ond sample includes the sample and a first spike of the analyte; performing mass analysis on the second one or more droplets to determine a second intensity of the analyte in the second one or more droplets; fitting a curve to the first intensity and the second intensity; and based on the fitted curve, calculating an analyte concentration for the sample.

公开(公告)号：US20240326055A1

公开(公告)日：2024-10-03

申请号：US18579231

申请日：2022-07-14

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. COVEY ,  Chang LIU

IPC: B01L3/00 ,  H01J49/04

CPC classification number: B01L3/502784 ,  H01J49/0431 ,  B01L2200/027 ,  B01L2300/0829 ,  B01L2400/0436

Abstract: Methods and systems for handling and/or analyzing samples are provided. In one example, a method comprises: introducing (406), with a liquid handler (322), at least one assisting agent into a sample well (310) of a well plate (312), wherein the sample comprises a sample volume; and ejecting (408), with an acoustic droplet ejector, ADE, (306), a mixture comprising the sample mixed with the at least one assisting agent from the sample well, wherein the at least one assisting agent interacts (406) with an analyte of the sample to limit gel formation at a top surface of the sample volume, prior to the mixture ejection.

公开(公告)号：US20240255473A1

公开(公告)日：2024-08-01

申请号：US18565850

申请日：2022-06-03

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. COVEY ,  Chang LIU

IPC: G01N30/06 ,  G01N30/02 ,  G01N30/72

CPC classification number: G01N30/06 ,  G01N30/7233 ,  G01N2030/027

Abstract: A system for analyzing a sample includes a sample preparation sub-system for preparing at least one sample in a sample vessel and a magnetic bead storage sub-system. A sample intake sub-system receives the at least one sample. A mass spectrometer (MS) is communicatively coupled to the sample intake sub-system. A transfer sub-system includes a tool for moving the sample vessel from the sample preparation sub-system to the sample intake sub-system.

公开(公告)号：US20240175787A1

公开(公告)日：2024-05-30

申请号：US18547787

申请日：2022-02-24

Applicant: Stephen TATE ,  Andras GUTTMAN ,  DH Technologies Development Pte. Ltd.

Inventor： Stephen TATE ,  Yves LE BLANC ,  Thomas R. COVEY

IPC: G01N1/14 ,  G01N1/38 ,  G01N30/02 ,  G01N30/72

CPC classification number: G01N1/14 ,  G01N1/38 ,  G01N30/7233 ,  G01N2001/149 ,  G01N2030/027

Abstract: A system includes a capillary having a first end connected to a sampling device and a second end. The sampling device is configured to separate a sample with a separation solution and deliver the sample and the separation solution to the second end. The second end is coupled to a capillary ground contact. A transport liquid supply system in fluidic communication with a transport liquid supply conduit provides a transport liquid from a transport liquid source through the transport liquid supply conduit. The transport liquid provided from the transport liquid supply conduit includes a receiving volume defined at least in part by a meniscus. The second end of the capillary is in fluidic communication with the receiving volume. A liquid exhaust system in fluidic communication with a removal conduit removes liquid from the receiving volume. An analysis system is in fluidic communication with the removal conduit.

公开(公告)号：US20240079225A1

公开(公告)日：2024-03-07

申请号：US18262829

申请日：2022-02-03

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. COVEY ,  Peter KOVARIK

IPC: H01J49/24 ,  F17D1/00 ,  G01N1/10 ,  G01N35/10 ,  H01J49/04 ,  H01J49/16

CPC classification number: H01J49/24 ,  F17D1/005 ,  G01N1/10 ,  G01N35/1095 ,  H01J49/0404 ,  H01J49/167 ,  B67D99/00

Abstract: A method of delivering transport fluid from an open port interface to an outlet via a transfer conduit includes delivering, to the open port interface, a transport liquid at a first flow rate. The open port interface is disposed in a pressure environment having a first pressure. A second pres-sure is applied at the outlet, wherein the second pressure is less than the first pressure. The pressure applied at the outlet generates a motive flow on the transport liquid, thereby drawing into the transfer conduit (a) the transport fluid, wherein the transport fluid is in contact with a wall of the transport conduit, and (b) a gas present in the pressure environment. The gas forms an air core within the drawn transport fluid. The air core extends substantially an entire length of the transfer conduit.

公开(公告)号：US20230197428A1

公开(公告)日：2023-06-22

申请号：US17999614

申请日：2021-05-20

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Thomas R. COVEY ,  Chang LIU

IPC: H01J49/04 ,  H01J49/24

CPC classification number: H01J49/0404 ,  H01J49/24 ,  H01J49/044

Abstract: In a sampling system for mass spectrometry, a method and apparatus are set forth for high flow-rate flushing and sample delivery via a sampling probe (10). The sampling system includes a sampling probe (10) having a first fluid conduit (40) with an inlet, a second fluid conduit (42) with an outlet, and a sampling port fluidly connecting the first fluid conduit (40) and second fluid conduit (42). A fluid source (50) is attached to the inlet and a vacuum source (60) is attached to the outlet for causing fluid to flow through the first fluid conduit (40) past the sampling port and exit through the second fluid conduit (42). A cap (90) is provided for selectively closing and opening the sampling port. When the cap is removed, thus when the sampling port is open, sample may be introduced into, and captured by fluid flowing through the sampling port. When the cap is in place, thus when the sampling port is closed, a flushing fluid is supplied for flushing the sampling probe (10).