公开(公告)号：US20180306759A1

公开(公告)日：2018-10-25

申请号：US16016866

申请日：2018-06-25

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER

IPC: G01N30/20 ,  G01N30/32 ,  G01N35/10 ,  G01N30/24 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N30/32 ,  G01N35/1097 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/207

Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

公开(公告)号：US20170003255A1

公开(公告)日：2017-01-05

申请号：US15269239

申请日：2016-09-19

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER ,  Adolf SATZINGER ,  Daniel BUERGER ,  Andreas UNGER

IPC: G01N30/60 ,  F16L25/00 ,  F16L37/02

CPC classification number: G01N30/6026 ,  F16L25/0018 ,  F16L37/02 ,  G01N2030/027

Abstract: A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit. A hollow cylindrical pressure piece is provided that surrounds the sealing element in an axial region facing away from the end surface of the plug capillary tube, and the pressure piece has a rearward end side that faces away from the end surface of the plug capillary tube and that can be loaded by the plug housing with an axial pressure force when the plug unit and bushing unit are connected.

Abstract translation: 用于连接毛细管的塞子单元包括具有轴向钻孔的塞子壳体，通过轴向孔眼突出的塞子毛细管和围绕塞子毛细管的密封元件。 插塞毛细管的前端通过密封元件的弹性和/或塑性变形抵靠衬套单元的毛细管插座开口密封。 提供一个中空的圆柱形压片，其在远离插塞毛细管的端面的轴向区域中围绕密封元件，并且压片具有背离插头毛细管的端面的后端侧， 当插头单元和衬套单元连接时，可以通过插头壳体以轴向压力加载。

公开(公告)号：US20160061789A1

公开(公告)日：2016-03-03

申请号：US14938029

申请日：2015-11-11

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER ,  Adolph SATZINGER ,  Daniel BUERGER ,  Andreas UNGER

IPC: G01N30/60 ,  F16L37/02 ,  F16L25/00

CPC classification number: G01N30/6026 ,  F16L25/0018 ,  F16L37/02 ,  G01N2030/027

Abstract: A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit. A hollow cylindrical pressure piece is provided that surrounds the sealing element in an axial region facing away from the end surface of the plug capillary tube, and the pressure piece has a rearward end side that faces away from the end surface of the plug capillary tube and that can be loaded by the plug housing with an axial pressure force when the plug unit and bushing unit are connected.

Abstract translation: 用于连接毛细管的塞子单元包括具有轴向钻孔的塞子壳体，通过轴向孔眼突出的塞子毛细管和围绕塞子毛细管的密封元件。 插塞毛细管的前端通过密封元件的弹性和/或塑性变形抵靠衬套单元的毛细管插座开口密封。 提供一个中空的圆柱形压片，其在远离插塞毛细管的端面的轴向区域中围绕密封元件，并且压片具有背离插头毛细管的端面的后端侧， 当插头单元和衬套单元连接时，可以通过插头壳体以轴向压力加载。

公开(公告)号：US20150128685A1

公开(公告)日：2015-05-14

申请号：US14534027

申请日：2014-11-05

Applicant: DIONEX SOFTRON GMBH

Inventor： Adolf SATZINGER ,  Hermann HOCHGRAEBER ,  Thomas Armin Alexander EICHHORN

IPC: G01N30/20 ,  G01N35/10

CPC classification number: G01N30/20 ,  F04B13/00 ,  G01N30/22 ,  G01N2030/207

Abstract: The invention relates to a sampler for providing a sample for high-performance liquid chromatography, in which a volume of liquid to be taken up into a cylinder can be aspirated by means of a first drive and can be compressed to a high pressure level by means of a second drive independent of the first drive or can be decompressed from this level in a controlled manner.

Abstract translation: 本发明涉及一种用于提供用于高效液相色谱的样品的采样器，其中待吸入气缸的液体体积可以通过第一驱动器吸入，并且可以通过装置被压缩到高压水平 独立于第一驱动器的第二驱动器，或者可以以受控的方式从该级别解压缩。

公开(公告)号：US20230070054A1

公开(公告)日：2023-03-09

申请号：US17929940

申请日：2022-09-06

Applicant: Dionex Softron GmbH

Inventor： Michael KOLBE ,  Christoph HOLLNAGEL ,  Hermann HOCHGRAEBER ,  Robert SPRINGER

IPC: G01N30/24 ,  B01D15/20

Abstract: The present invention relates to a needle (1), wherein the needle (1) comprises a channel (12) extending through the needle (1), wherein the needle (1) comprises a needle tip (11), wherein the channel (12) comprises an opening at the needle tip (11), wherein the needle (1) defines an axial direction (x), wherein the axial direction (x) defines a distal direction and a proximal direction, wherein the needle tip (11) is a distal portion of the needle (1), and wherein the needle tip (11) comprises a first surface section (112) and a second surface section (111), wherein the first surface section (112) is arranged at a first angle (α) with respect to the axial direction (x) and the second surface section (111) is arranged at a second angle (β) with respect to the axial direction (x), wherein the first angle is different from the second angle. The present invention also relates to a corresponding apparatus, system and use.

公开(公告)号：US20180128789A1

公开(公告)日：2018-05-10

申请号：US15809136

申请日：2017-11-10

Applicant: DIONEX SOFTRON GMBH

Inventor： Christoph HOLLNAGEL ,  Remco SWART ,  Hermann HOCHGRAEBER

IPC: G01N30/32 ,  G01N30/22

CPC classification number: G01N30/32 ,  G01N30/20 ,  G01N30/22 ,  G01N30/24 ,  G01N2030/027

Abstract: A method performed in a liquid chromatography system that includes a metering device pushing a sample into a trap column. The metering device sucks in the sample from a sample reservoir, wherein the sucking in the sample from a sample reservoir precedes the step of pushing the sample into the trap column. The liquid chromatography system also includes a trap column and a metering device (100), wherein the system (1000) is adapted to assume a configuration allowing the metering device (100) to push a sample into the trap column (6) and wherein the metering device (100) is adapted to push the sample into the trap column (6) in this configuration, wherein the system (1000) is adapted to assume a configuration allowing the sample to be sucked into the system (1000) by means of the metering device (100). Furthermore, the invention relates to a use of the liquid chromatography system (1000) for liquid chromatography, in particular of high pressure liquid chromatography.

公开(公告)号：US20170284980A1

公开(公告)日：2017-10-05

申请号：US15625691

申请日：2017-06-16

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER ,  Joachim WIECHERS ,  Adolf SATZINGER

IPC: G01N30/20 ,  G01N30/22 ,  F16K11/076

CPC classification number: G01N30/20 ,  F16K11/0743 ,  F16K11/076 ,  G01N30/22 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/204

Abstract: A high-pressure switching valve includes a stator and a rotor. The stator includes a plurality of ports where each port is connected at one end to a port connection and having at another end a predetermined port opening cross section at a stator end face of the stator. The rotor includes a rotor end face and at least one or a plurality of grooves. The rotor can be configured to have a rotary position with respect to the stator where two predetermined port opening cross sections connect to one of the grooves in a pressure-tight manner. The rotor and the stator can be pressed together in a sealing manner at the rotor end face and the stator end face in regions away from the port opening cross sections and the at least one or a plurality of grooves. The rotor and the stator each include a hard material. The rotor can be configured to wobble or tilt with respect to a rotational axis of the rotor.

公开(公告)号：US20150308989A1

公开(公告)日：2015-10-29

申请号：US14792215

申请日：2015-07-06

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER ,  Adolf SATZINGER ,  Daniel BUERGER ,  Andreas UNGER

IPC: G01N30/60

CPC classification number: G01N30/6026 ,  F16L25/0018 ,  F16L37/02 ,  G01N2030/027

Abstract: A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit. A hollow cylindrical pressure piece is provided that surrounds the sealing element in an axial region facing away from the end surface of the plug capillary tube, and the pressure piece has a rearward end side that faces away from the end surface of the plug capillary tube and that can be loaded by the plug housing with an axial pressure force when the plug unit and bushing unit are connected.

Abstract translation: 用于连接毛细管的塞子单元包括具有轴向钻孔的塞子壳体，通过轴向孔眼突出的塞子毛细管和围绕塞子毛细管的密封元件。 插塞毛细管的前端通过密封元件的弹性和/或塑性变形抵靠衬套单元的毛细管插座开口密封。 提供一个中空的圆柱形压片，其在远离插塞毛细管的端面的轴向区域中围绕密封元件，并且压片具有背离插头毛细管的端面的后端侧， 当插头单元和衬套单元连接时，可以通过插头壳体以轴向压力加载。

公开(公告)号：US20150265944A1

公开(公告)日：2015-09-24

申请号：US14661793

申请日：2015-03-18

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER ,  Thomas WACHINGER

IPC: B01D15/16

CPC classification number: B01D15/166 ,  G01N30/34

Abstract: The invention relates to a method for setting a gradient delay volume GDV of a liquid chromatography system for a chromatography run in liquid chromatography, in particular a high-performance liquid chromatography system, in which a desired value GDVtarget of a gradient delay volume of the liquid chromatography system is ascertained or predefined and, if the value GDVtarget deviates from a specific fixed value GDVactual of a liquid chromatography system, this value GDVtarget is set in a range 0≦ΔGDV=GDVtarget−GDVactual≦Vmax of a volume of a volume adjustment device 5. Furthermore, the invention relates to an automatic sampler for carrying out such a method.

Abstract translation: 本发明涉及一种用于设置液相色谱系统的液相色谱系统的梯度延迟体积GDV的方法，用于液相色谱法，特别是高效液相色谱系统中的色谱法，其中液体的梯度延迟体积的期望值GDV靶 确定或预定色谱系统，并且如果值GDVtarget偏离液相色谱系统的特定固定值GDVactual，则该值GDVtarget被设置在体积体积的范围0＆lt; nlE;＆Dgr; GDV = GDVtarget-GDVactual＆nlE; Vmax 调整装置5.此外，本发明涉及一种用于执行这种方法的自动取样器。