公开(公告)号：US20070207124A1

公开(公告)日：2007-09-06

申请号：US11261389

申请日：2005-10-28

Applicant: Joseph Glorioso ,  David Fink ,  Darren Wolfe ,  David Krisky

Inventor： Joseph Glorioso ,  David Fink ,  Darren Wolfe ,  David Krisky

IPC: A61K48/00 ,  C12N15/86

Abstract: The invention provides a vector, preferably a herpes simplex virus (HSV) vector, comprising a polynucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein. The invention also provides a stock of such vectors and a pharmaceutical composition comprising such vectors. The invention further provides a method of treating pain, such as spinal cord injury pain, in a mammal comprising administering to a mammal a vector comprising a nucleotide sequence encoding a glutamic acid decarboxylase (GAD) protein in an amount effective to treat spinal cord injury pain.

Abstract translation: 本发明提供了一种载体，优选包含编码谷氨酸脱羧酶（GAD）蛋白的多核苷酸序列的单纯疱疹病毒（HSV）载体。 本发明还提供了这种载体的储备物和包含这些载体的药物组合物。 本发明还提供了一种治疗哺乳动物疼痛，如脊髓损伤疼痛的方法，包括向哺乳动物施用含有编码谷氨酸脱羧酶（GAD）蛋白的核苷酸序列的载体，其量为有效治疗脊髓损伤疼痛 。

公开(公告)号：US20070020320A1

公开(公告)日：2007-01-25

申请号：US11485481

申请日：2006-07-13

Applicant: Nicole David ,  David Fink ,  Alain Tranchemontagne

Inventor： Nicole David ,  David Fink ,  Alain Tranchemontagne

IPC: A61L15/00 ,  A61K33/34 ,  A61K33/22 ,  A61K33/38 ,  A61K33/32

CPC classification number: A61K45/06 ,  A61K33/00 ,  A61K33/08 ,  A61K33/24 ,  A61K33/30 ,  A61K33/38 ,  A61K33/42 ,  A61L15/46 ,  A61L26/0061 ,  A61L26/0066 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/62 ,  C03C3/16 ,  C03C4/0014 ,  C03C4/0035 ,  C03C2204/02 ,  A61K2300/00

Abstract: Anti-microbial wound dressings, methods of making anti-microbial wound dressings and methods of treating wounds with an anti-microbial wound dressing are provided. The anti-microbial wound dressings can include a water-soluble film-forming polymeric carrier material and a water-soluble glass-encapsulated anti-microbial agent, which is embedded within the carrier and/or coated on a surface thereof. Additional active agents useful in wound care can also be embedded in and/or coated on a surface of the carrier and/or water-soluble glass.

Abstract translation: 提供抗微生物伤口敷料，制造抗微生物伤口敷料的方法以及用抗微生物伤口敷料治疗伤口的方法。 抗微生物伤口敷料可以包括水溶性成膜聚合物载体材料和水溶性玻璃包封的抗微生物剂，其被嵌入载体内和/或涂覆在其表面上。 可用于伤口护理的其它活性剂也可嵌入载体和/或水溶性玻璃的表面和/或涂覆在载体和/或水溶性玻璃的表面上。

公开(公告)号：US20060281070A1

公开(公告)日：2006-12-14

申请号：US11445837

申请日：2006-06-01

Applicant: Darren Wolfe ,  Joseph Glorioso ,  David Fink

Inventor： Darren Wolfe ,  Joseph Glorioso ,  David Fink

IPC: A61K48/00 ,  C12Q1/00 ,  C07H21/04 ,  C07K14/47 ,  C07K14/475

CPC classification number: C07K5/1016 ,  A61K48/005 ,  C07K7/22 ,  C07K14/67 ,  C07K14/695 ,  C07K14/70 ,  C07K2319/50 ,  C07K2319/60 ,  C12N15/86 ,  C12N2710/16643 ,  G01N33/6893 ,  G01N33/9486 ,  G01N2800/2842

Abstract: The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GFP)) all in operable linkage and under control of a promoter. Where the encoded precursor of a carboxy-amidated peptide is an agonist for an opioid receptor, the invention further provides a method of treating neuropathic pain by administering the gene transfer vector comprising such an expression cassette to a patient. The invention also provides a method for detecting a peptide having a desired effect comprising introducing a library of DNA sequences encoding one or more precursors of carboxy-amidated peptides into host cells; expressing the carboxy-amidated peptides encoded in the library to provide expression products; and screening from the polypeptide expression products for the desired effect.

Abstract translation: 本发明提供了一种表达盒，其包含编码人前脑啡肽的氨基酸1-99的DNA序列，编码侧翼为二碱基切割位点的羧基酰胺化肽的前体的DNA序列和任选的编码标记蛋白的DNA序列（例如增强型 绿色荧光蛋白（GFP））都在可操作的连锁和启动子的控制下。 当羧基酰胺化肽的编码前体是阿片受体的激动剂时，本发明还提供了通过将包含这种表达盒的基因转移载体给予患者来治疗神经性疼痛的方法。 本发明还提供了一种检测具有所需效果的肽的方法，包括将编码羧基酰胺化肽的一种或多种前体的DNA序列文库导入宿主细胞; 表达在文库中编码的羧基酰胺化肽以提供表达产物; 并从多肽表达产物筛选出所需的效果。

公开(公告)号：US5878134A

公开(公告)日：1999-03-02

申请号：US925547

申请日：1997-09-08

Applicant: Doron Handelman ,  Moshe Kranc ,  David Fink ,  Arnold Zucker ,  Perry Smith ,  Gerson Bar-On

Inventor： Doron Handelman ,  Moshe Kranc ,  David Fink ,  Arnold Zucker ,  Perry Smith ,  Gerson Bar-On

IPC: G06K19/00 ,  G06F21/10 ,  G06K7/00 ,  G07C9/00 ,  G07F7/10 ,  H04N5/445 ,  H04N7/16 ,  H04N21/418 ,  H04N21/4405 ,  H04N21/4545 ,  H04N21/4623 ,  H04L9/00 ,  H04N7/167 ,  G06F7/04

CPC classification number: G07F7/1008 ,  G06K7/0004 ,  G06K7/0034 ,  G06Q20/341 ,  G06Q20/346 ,  G06Q20/3578 ,  G06Q20/35785 ,  G07C9/00119 ,  H04N21/4181 ,  H04N21/4405 ,  H04N21/4623 ,  H04N7/163 ,  H04N5/445

Abstract: A secure access system for controlling access to a plurality of items. The system includes a first IC card reader adapted to receive a first IC card which includes first control information, a second IC card reader adapted to receive a second IC card which includes second control information, and a control integrator receiving the first control information and the second control information and allowing access to a first one of the plurality of items based, at least in part, on both the first control information and said second control information, and to a second one of the plurality of items based, at least in part, on the first control information, without regard to the second control information.

Abstract translation: 一种用于控制对多个项目的访问的安全访问系统。 该系统包括适于接收包括第一控制信息的第一IC卡的第一IC卡读卡器，适于接收包括第二控制信息的第二IC卡的第二IC卡读取器，以及接收第一控制信息的控制积分器和 至少部分地至少部分地基于第一控制信息和所述第二控制信息以及至少部分地基于第二控制信息访问多个项目中的第一项目，以及至少部分地基于第二控制信息 关于第一控制信息，而不考虑第二控制信息。

公开(公告)号：US5368309A

公开(公告)日：1994-11-29

申请号：US62304

申请日：1993-05-14

Applicant: Marshall Monroe ,  David Fink

Inventor： Marshall Monroe ,  David Fink

IPC: A63F13/08 ,  H04N13/00 ,  A63F9/22

CPC classification number: A63F13/52 ,  A63F13/08 ,  H04N13/0443 ,  H04N13/0459 ,  H04N13/0285 ,  H04N13/0495

Abstract: The invention is directed to an interactive video game whereby players sit opposite each other and view the game and each other through a semi-transparent image generated in real-time through the use of a first-surface reflection. The present invention uses opposing Heads-Up Displays (HUDs). Using opposing HUDs, an image can be apparently suspended between two players. The surface on which the image is displayed has sufficient transparency to allow each player to see the other player along with the image. Thus, the players can interact during play allowing for a more enhanced reward in the experience. The effect could be further enhanced by the use of stereo glasses and a stereo-pair of images on the display such that the players see 3-D images on the playing "surface." To further enhance the interactive experience, the virtual images are substantially coincident so that when one player looks up from the action in the game to see the opponent, the opponent's eyes are looking at roughly the same spot in space where the first player perceives the action to be. Thus, the present invention yields more direct communication between players, as well as an enhanced experience. The present invention yields additional applications such as where each player sees any number of images which correspond to the image of the "opponent," or "electronic painting" applications. Other games can take advantage of the fact that the image is superimposed on the opponent such as trying new facial features or clothing.

Abstract translation: 本发明涉及一种交互式视频游戏，其中玩家彼此相对并且通过使用第一表面反射实时生成的半透明图像来观看游戏。 本发明使用相反的头戴式显示器（HUD）。 使用相反的HUD，两个玩家之间的图像显然会被暂停。 显示图像的表面具有足够的透明度，以允许每个玩家与图像一起看到另一个玩家。 因此，玩家可以在游戏过程中进行交互，从而在体验中获得更多的奖励。 可以通过在显示器上使用立体眼镜和立体声图像来进一步增强效果，使得玩家在玩“表面”上看到3-D图像。 为了进一步增强互动体验，虚拟图像基本上是一致的，所以当一个玩家从游戏中的动作看起来看对方时，对手的眼睛正在看到第一玩家感觉到动作的空间大致相同的地方 成为。 因此，本发明在玩家之间产生更直接的沟通，并且增强了经验。 本发明产生其他应用，例如每个玩家看到与“对手”或“电子绘画”应用的图像相对应的任何数量的图像。 其他游戏可以利用图像叠加在对手上的事实，例如尝试新的面部特征或衣服。

公开(公告)号：US5216164A

公开(公告)日：1993-06-01

申请号：US833484

申请日：1992-02-10

Applicant: Richard C. Effland ,  David Fink

Inventor： Richard C. Effland ,  David Fink

IPC: C07D215/22 ,  C07D215/227 ,  C07D215/38

CPC classification number: C07D215/227 ,  C07D215/38

Abstract: Novel 5-amino-5,6,7,8-tetrahydroquinolines and related compounds, intermediates and processes for the preparation thereof, and methods for relieving memory dysfunction utilizing compounds or compositions thereof are disclosed.

Abstract translation: 公开了新的5-氨基-5,6,7,8-四氢喹啉及其相关化合物，其制备方法及其制备方法，以及利用化合物或其组合物缓解记忆功能障碍的方法。

公开(公告)号：USD312530S

公开(公告)日：1990-12-04

申请号：US41590

申请日：1987-04-23

Applicant: Joseph Gallen ,  David Fink

Designer： Joseph Gallen ,  David Fink

公开(公告)号：US4511625A

公开(公告)日：1985-04-16

申请号：US429186

申请日：1982-09-30

Applicant: Faramarz Nazem ,  Rostislav Didchenko ,  David Fink

Inventor： Faramarz Nazem ,  Rostislav Didchenko ,  David Fink

IPC: C10C3/14 ,  D01D4/02 ,  D01F9/14 ,  D01F9/145 ,  D01F9/155 ,  D01F9/32 ,  C10C3/18 ,  D01D1/04 ,  D01D5/08

CPC classification number: D01F9/322 ,  C10C3/14 ,  D01F9/145 ,  Y10S264/19 ,  Y10T428/298

Abstract: A process of spinning a pitch having less than 40% by weight mesophase into a pitch fiber having at least 70% by weight mesophase is described.

Abstract translation: 描述了将具有小于40重量％中间相的沥青纺丝成具有至少70重量％中间相的沥青纤维的方法。

公开(公告)号：US09057604B1

公开(公告)日：2015-06-16

申请号：US07338009

申请日：1989-04-14

Applicant: David Fink

Inventor： David Fink

IPC: G01B11/26 ,  G01C1/00

CPC classification number: G01B11/26 ,  G01C1/00 ,  G01S7/481 ,  G01S7/497 ,  G01S17/66

Abstract: Point-ahead laser pointer-tracker systems with stabilization and wavefront correction in both transmit and receive directions provide arrangements for sensing the wavefront correction required in two different directions, one in the received target image direction for good image quality in the tracker and the other in the point-ahead direction for good beam quality on the target. In the several embodiments, a marker beam is aligned with the target image. Wavefront aberration correction signals are produced by an output wave sensor that senses the wavefront of the marker beam in the received target image direction and the wavefront of the source laser beam in the point-ahead transmit direction. The alignment is maintained by use of the output wave sensor signals together with signals from the tracker of the target and current aimpoint positions. These signals, compared in selected pairs, control mirrors in various legs of the optical system to put the current aimpoint on the desired aimpoint and to align the marker beam along the received target image direction.

Abstract translation: 在发射和接收方向上具有稳定和波前校正的点前激光指示器跟踪器系统提供用于感测在两个不同方向上所需的波前校正的布置，一个在接收到的目标图像方向上，以获得跟踪器中的良好图像质量，另一个在 目标的良好光束质量的提前方向。 在几个实施例中，标记光束与目标图像对准。 波前像差校正信号由输出波传感器产生，该输出波传感器感测接收到的目标图像方向上的标记光束的波前和源点激光束的波前在提前发射方向上。 通过使用输出波传感器信号和来自目标跟踪器的当前目标位置的信号来维持对准。 这些信号在所选择的对中进行比较，控制光学系统的各个支路中的反射镜，以将当前瞄准点放置在期望的瞄准点上，并沿着所接收的目标图像方向对准标记光束。

公开(公告)号：US08580749B2

公开(公告)日：2013-11-12

申请号：US12795195

申请日：2010-06-07

Applicant: Joseph Wagner ,  Randell Young ,  David Fink

Inventor： Joseph Wagner ,  Randell Young ,  David Fink

IPC: A61K38/08

CPC classification number: A61K35/28 ,  A61K47/543 ,  A61K47/64

Abstract: Embodiments of the present invention are directed to a coated cell comprising a therapeutic cell and a plurality of targeting complexes coating the therapeutic cell and each of said targeting complexes comprising a homing molecule, a lipid moiety, and a spacer having from about 1 to about 10 amino acids and covalently linking the homing molecule to the lipid moiety and wherein the lipid moiety is non-covalently attached to the therapeutic cell. In some embodiments, the therapeutic cell is a stem cell. Embodiments of the invention are directed to methods of coating a therapeutic cell. Embodiments of the invention are directed to methods of treating diseases of the vasculature.

Abstract translation: 本发明的实施方案涉及包含治疗细胞和涂覆治疗细胞的多种靶向复合物的涂覆细胞，并且每种所述靶向复合物包含归巢分子，脂质部分和具有约1至约10个 氨基酸，并将归巢分子与脂质部分共价连接，并且其中脂质部分非共价连接到治疗细胞上。 在一些实施方案中，治疗细胞是干细胞。 本发明的实施方案涉及涂覆治疗细胞的方法。 本发明的实施方案涉及治疗脉管系统疾病的方法。