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公开(公告)号：US5935954A
公开(公告)日：1999-08-10
申请号：US961551
申请日：1997-10-30
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/70 , A61K31/7008 , A61K38/00 , A61K38/22 , A61K45/00 , A61P35/00 , A61P43/00 , C07D211/60 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
CPC分类号： C07D401/12 , C07D211/60 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.
摘要翻译： 本发明涉及能够维持，增加或恢复细胞对治疗或预防剂敏感性的化合物。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于治疗多药耐药性细胞，用于预防多药耐药性的发展，并用于多药耐药性癌症治疗。
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公开(公告)号：US5807876A
公开(公告)日：1998-09-15
申请号：US636361
申请日：1996-04-23
申请人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
发明人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
IPC分类号： A61K31/17 , A61K31/18 , A61K31/404 , A61K31/42 , A61K31/421 , A61K31/422 , A61P9/14 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07C275/42 , C07D263/18 , C07D263/32 , C07D277/18 , C07D413/12 , C07D263/34 , C07D413/00
CPC分类号： C07D413/12 , A61K31/404 , A61K31/42 , A61K31/422 , C07C275/42 , C07D263/32
摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as agents for immunosuppression. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
摘要翻译： 本发明涉及一类新颖的IMPDH抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作免疫抑制剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。
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公开(公告)号：US06967214B2
公开(公告)日：2005-11-22
申请号：US10351731
申请日：2003-01-23
申请人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
发明人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
IPC分类号： A61K31/17 , A61K31/18 , A61K31/404 , A61K31/42 , A61K31/421 , A61K31/422 , A61P9/14 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07C275/42 , C07D263/18 , C07D263/32 , C07D277/18 , C07D413/12 , A61P31/22
CPC分类号： C07D413/12 , A61K31/404 , A61K31/42 , A61K31/422 , C07C275/42 , C07D263/32 , Y02P20/55
摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
摘要翻译： 本发明涉及一类新颖的IMPDH抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作IMPDH介导的过程的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。
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公开(公告)号：US06518291B1
公开(公告)日：2003-02-11
申请号：US09395798
申请日：1999-09-14
申请人： Jeffrey O. Saunders , David M. Armistead , Michael C. Badia , Randy S. Bethiel , Catherine A. Frank , Doug Naegele , Perry M. Novak , David A. Pearlman , Steven M. Ronkin
发明人： Jeffrey O. Saunders , David M. Armistead , Michael C. Badia , Randy S. Bethiel , Catherine A. Frank , Doug Naegele , Perry M. Novak , David A. Pearlman , Steven M. Ronkin
IPC分类号： A61K31136
CPC分类号： C07D263/58 , A61K31/4184 , A61K31/423 , A61K31/428 , C07D235/30 , C07D413/12 , C07D417/12 , Y02A50/385 , Y02A50/389
摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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公开(公告)号：US06344465B1
公开(公告)日：2002-02-05
申请号：US08801780
申请日：1997-02-14
申请人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
发明人： David M. Armistead , Michael C. Badia , Guy W. Bemis , Randy S. Bethiel , Catharine A. Frank , Perry M. Novak , Steven M. Ronkin , Jeffrey O. Saunders
IPC分类号： A61K31445
CPC分类号： C07D413/12 , A61K31/404 , A61K31/42 , A61K31/422 , C07C275/42 , C07D263/32
摘要： The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
摘要翻译： 本发明涉及一类新颖的IMPDH抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制IMPDH酶活性，因此可有利地用作IMPDH介导的过程的治疗剂。 本发明还涉及使用本发明化合物和相关化合物抑制IMPDH活性的方法。
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公开(公告)号：US5717092A
公开(公告)日：1998-02-10
申请号：US626259
申请日：1996-03-29
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/70 , A61K31/7008 , A61K38/00 , A61K38/22 , A61K45/00 , A61P35/00 , A61P43/00 , C07D211/60 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D211/06 , C07D211/36
CPC分类号： C07D401/12 , C07D211/60 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.
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公开(公告)号：US09328077B2
公开(公告)日：2016-05-03
申请号：US13996286
申请日：2011-12-21
IPC分类号： C07D265/36 , C07D265/18 , C07D413/12
CPC分类号： C07D413/12 , C07D265/18 , C07D265/36
摘要： Compounds and compositions comprising compounds that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that activate PKM2 in the treatment of cancer.
摘要翻译： 包含激活丙酮酸激酶M2（PKM2）的化合物的化合物和组合物在本文中描述。 本文还描述了使用激活PKM2的化合物治疗癌症的方法。
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公开(公告)号：US08785450B2
公开(公告)日：2014-07-22
申请号：US12826630
申请日：2010-06-29
IPC分类号： A61K31/496 , A61K31/4709 , C07D215/36 , C07D401/12 , C07D401/14 , C07D405/06 , C07D471/00
CPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , Y02P20/582
摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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公开(公告)号：US20120122849A1
公开(公告)日：2012-05-17
申请号：US13289551
申请日：2011-11-04
IPC分类号： A61K31/551 , C07D417/12 , C07D413/12 , C07D339/06 , C07D409/12 , A61P35/00 , A61K31/428 , A61K31/385 , A61K31/4436 , A61K31/496 , A61K31/4709 , C07D263/58 , A61K31/423
CPC分类号： C07D263/58 , C07D277/68 , C07D339/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are pharmaceutical compositions comprising the compounds, and methods of using the compounds in the treatment of cancer.
摘要翻译： 本文描述了调节丙酮酸激酶M2（PKM2）的化合物。 本文还描述了包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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公开(公告)号：US20120088747A1
公开(公告)日：2012-04-12
申请号：US13126613
申请日：2009-10-30
申请人： Jeffrey O. Saunders
发明人： Jeffrey O. Saunders
IPC分类号： A61K31/5377 , C07D403/04 , C07D413/04 , C07D405/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D411/06 , C07D403/12 , C07D403/14 , C07D417/12 , C07D401/12 , A61K31/4196 , A61K31/433 , A61K31/454 , A61K31/498 , A61K31/506 , A61P3/10 , A61P27/02 , A61P25/00 , A61P13/12 , A61P3/00 , A61P9/00 , C07D249/08
CPC分类号： C07D249/08 , A61K31/40 , A61K31/44 , C07D249/10 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/06 , C07D411/06 , C07D413/04
摘要： Compounds, compositions and methods for treating GHS-R mediated disorders are described herein.
摘要翻译： 本文描述了用于治疗GHS-R介导的病症的化合物，组合物和方法。
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