公开(公告)号：US10004442B2

公开(公告)日：2018-06-26

申请号：US14860392

申请日：2015-09-21

Applicant: DexCom, Inc.

Inventor： Sebastian Böhm ,  Daiting Rong ,  Peter C. Simpson

IPC: G08B21/00 ,  A61B5/1495 ,  G01N27/327 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  G01D18/00 ,  G01N27/02 ,  G01N33/49 ,  A61B5/1473

CPC classification number: A61B5/1495 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/7257 ,  A61B5/7267 ,  A61B2560/0276 ,  G01D18/00 ,  G01N27/026 ,  G01N27/3274 ,  G01N33/49 ,  H05K999/00 ,  H05K999/99

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

公开(公告)号：US20180008174A1

公开(公告)日：2018-01-11

申请号：US15713450

申请日：2017-09-22

Applicant: DexCom, Inc.

Inventor： Sebastian Böhm ,  Daiting Rong ,  Peter C. Simpson

IPC: A61B5/1495 ,  G01N27/327 ,  G01N27/02 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  G01N33/49 ,  G01D18/00

CPC classification number: A61B5/1495 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/7257 ,  A61B5/7267 ,  A61B2560/0276 ,  G01D18/00 ,  G01N27/026 ,  G01N27/3274 ,  G01N33/49 ,  H05K999/00 ,  H05K999/99

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

公开(公告)号：US09763608B2

公开(公告)日：2017-09-19

申请号：US14960011

申请日：2015-12-04

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Böhm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC: A61B5/05 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/10

CPC classification number: A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

公开(公告)号：US20160081600A1

公开(公告)日：2016-03-24

申请号：US14960011

申请日：2015-12-04

Applicant: DexCom, Inc

Inventor： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Böhm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC: A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

Abstract translation: 提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。 例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。 传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成，绝缘层810将导电层820与细长主体分隔开;膜层沉积在 通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。

公开(公告)号：US20150351672A1

公开(公告)日：2015-12-10

申请号：US14717965

申请日：2015-05-20

Applicant: DexCom, Inc.

Inventor： Stephen J. Vanslyke ,  Naresh C. Bhavaraju ,  Sebastian Böhm ,  Leif N. Bowman ,  Michael J. Estes ,  Arturo Garcia ,  Apurv Ullas Kamath ,  Andrew Attila Pal ,  Thomas A. Peyser ,  Anna Leigh Rack-Gomer ,  Daiting Rong ,  Disha B. Sheth ,  Peter C. Simpson ,  Dmytro Sokolovsky

IPC: A61B5/1495 ,  A61B5/01 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/053 ,  A61B5/00 ,  A61B5/11

CPC classification number: A61B5/1495 ,  A61B5/01 ,  A61B5/053 ,  A61B5/1118 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4833 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/4866 ,  A61B5/6898 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7275 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/746 ,  A61B2560/0247 ,  A61B2560/0252 ,  A61B2560/0276 ,  A61B2560/0475 ,  A61B2562/0247 ,  A61M5/1723 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00

Abstract: Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

公开(公告)号：US20150351671A1

公开(公告)日：2015-12-10

申请号：US14717904

申请日：2015-05-20

Applicant: DexCom, Inc.

Inventor： Stephen J. Vanslyke ,  Naresh C. Bhavaraju ,  Sebastian Böhm ,  Leif N. Bowman ,  Michael J. Estes ,  Arturo Garcia ,  Apurv Ullas Kamath ,  Andrew Attila Pal ,  Thomas A. Peyser ,  Anna Leigh Rack-Gomer ,  Daiting Rong ,  Disha B. Sheth ,  Peter C. Simpson ,  Dmytro Sokolovsky

IPC: A61B5/1495 ,  A61B5/145 ,  A61M5/172 ,  A61B5/053 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/01

CPC classification number: A61B5/1495 ,  A61B5/01 ,  A61B5/053 ,  A61B5/1118 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4833 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/4866 ,  A61B5/6898 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7275 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/746 ,  A61B2560/0247 ,  A61B2560/0252 ,  A61B2560/0276 ,  A61B2560/0475 ,  A61B2562/0247 ,  A61M5/1723 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00

Abstract: Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

公开(公告)号：US12053283B2

公开(公告)日：2024-08-06

申请号：US17207461

申请日：2021-03-19

Applicant: DexCom, Inc.

Inventor： Michael J. Estes ,  Stephen J. Vanslyke ,  Apurv Ullas Kamath ,  Thomas A. Peyser ,  Lucas Bohnett ,  Aarthi Mahalingam ,  Arturo Garcia ,  Peter C. Simpson ,  Anna Leigh Davis ,  Sebastian Böhm

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1495 ,  G01D3/02 ,  G16H20/17 ,  G16H40/67

CPC classification number: A61B5/1495 ,  A61B5/14532 ,  A61B5/7203 ,  G01D3/022 ,  A61B5/0031 ,  A61B5/14503 ,  A61B2560/0223 ,  A61B2562/02 ,  G16H20/17 ,  G16H40/67

Abstract: Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously.

公开(公告)号：US10667733B2

公开(公告)日：2020-06-02

申请号：US14968643

申请日：2015-12-14

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Sebastian Böhm ,  James H. Brauker ,  Paul V. Neale

IPC: A61B5/1486 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/00

Abstract: A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.

公开(公告)号：US20200037936A1

公开(公告)日：2020-02-06

申请号：US16586610

申请日：2019-09-27

Applicant: DexCom, Inc.

Inventor： Sebastian Böhm ,  Daiting Rong ,  Peter C. Simpson

IPC: A61B5/1495 ,  G01N27/327 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  G01D18/00 ,  G01N27/02 ,  G01N33/49 ,  A61B5/1473

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

公开(公告)号：US20200037934A1

公开(公告)日：2020-02-06

申请号：US16586407

申请日：2019-09-27

Applicant: DexCom, Inc.

Inventor： Sebastian Böhm ,  Daiting Rong ,  Peter C. Simpson

IPC: A61B5/1495 ,  G01N27/327 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  G01D18/00 ,  G01N27/02 ,  G01N33/49 ,  A61B5/1473

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.