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32 条记录 (耗时 0.061 秒)

    Antagonists of interleukin-15
    12.
    发明授权
    Antagonists of interleukin-15 失效
    白细胞介素15的拮抗剂

    公开(公告)号：US07235240B2

    公开(公告)日：2007-06-26

    申请号：US11221399

    申请日：2005-09-07

    申请人： Kenneth H. Grabstein ,  Dean K. Pettit ,  Raymond J. Paxton

    发明人： Kenneth H. Grabstein ,  Dean K. Pettit ,  Raymond J. Paxton

    IPC分类号： A61K39/00 ,  A61K39/38 ,  A01N37/18

    CPC分类号： C07K16/244 ,  A61K38/00 ,  A61K47/60 ,  C07K14/5443 ,  C07K2317/76

    摘要： Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are incapable of transducing a signal through either the β- or γ-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the β- or γ-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease,

    摘要翻译： 公开了哺乳动物白细胞介素-15（“IL-15”）的拮抗剂，并且包括IL-15和修饰的IL-15分子的突变蛋白，其各自能够结合IL-15Rα-亚基并且不能通过 IL-15受体复合物的β亚基或γ亚基。 还包括针对IL-15的单克隆抗体，其阻止IL-15通过IL-15受体复合物的β亚基或γ亚基进行信号转导。 公开了治疗各种疾病状态的方法，包括治疗同种异体移植排斥和移植物抗宿主病，

    Antagonists of interleukin-15
    13.
    发明授权
    Antagonists of interleukin-15 有权
    白细胞介素15的拮抗剂

    公开(公告)号：US06177079B1

    公开(公告)日：2001-01-23

    申请号：US09196427

    申请日：1998-11-20

    申请人： Kenneth H. Grabstein ,  Dean K. Pettit ,  Raymond J. Paxton

    发明人： Kenneth H. Grabstein ,  Dean K. Pettit ,  Raymond J. Paxton

    IPC分类号： A61K39395

    CPC分类号： C07K16/244 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/5443

    摘要： Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15R&agr;-subunit and that are incapable of transducing a signal through either the &bgr;- or &ggr;-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the B- or &ggr;subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed. including treating allograft rejection and graft-versus-host disease.

    摘要翻译： 公开了哺乳动物白细胞介素-15（“IL-15”）的拮抗剂，并且包括IL-15和修饰的IL-15分子的突变蛋白，其各自能够结合IL-15Rα-亚基并且不能通过 IL-15受体复合物的β亚基或γ亚基。 还包括针对IL-15的单克隆抗体，其阻止IL-15通过IL-15受体复合物的B-或gammasubunits进行信号转导。 公开了治疗各种疾病状态的方法。 包括治疗同种异体移植排斥和移植物抗宿主病。

    Antagonists of interleukin-15
    15.
    发明授权
    Antagonists of interleukin-15 失效
    白细胞介素15的拮抗剂

    公开(公告)号：US07067132B2

    公开(公告)日：2006-06-27

    申请号：US10289114

    申请日：2002-11-06

    申请人： Kenneth H. Grabstein ,  Dean K. Pettit ,  Raymond J. Paxton

    发明人： Kenneth H. Grabstein ,  Dean K. Pettit ,  Raymond J. Paxton

    IPC分类号： A61K39/395 ,  C07K16/00

    CPC分类号： C07K16/244 ,  A61K38/00 ,  A61K47/60 ,  C07K14/5443 ,  C07K2317/76

    摘要： Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are incapable of transducing a signal through either the β- or γ-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the β- or γ-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease.

    摘要翻译： 公开了哺乳动物白细胞介素-15（“IL-15”）的拮抗剂，并且包括IL-15和修饰的IL-15分子的突变蛋白，其各自能够结合IL-15Rα-亚基并且不能通过 IL-15受体复合物的β亚基或γ亚基。 还包括针对IL-15的单克隆抗体，其阻止IL-15通过IL-15受体复合物的β亚基或γ亚基进行信号转导。 公开了治疗各种疾病状态的方法，包括治疗同种异体移植排斥和移植物抗宿主病。

    Muscle trophic factor
    18.
    发明授权
    Muscle trophic factor 失效
    肌肉营养因子

    公开(公告)号：US5660824A

    公开(公告)日：1997-08-26

    申请号：US535733

    申请日：1995-05-24

    申请人： Kenneth H. Grabstein ,  LeBris S. Quinn ,  Anthony B. Troutt

    发明人： Kenneth H. Grabstein ,  LeBris S. Quinn ,  Anthony B. Troutt

    IPC分类号： A23K20/195 ,  A61K31/56 ,  A61K38/00 ,  A61K38/27 ,  A61K38/30 ,  A61P3/00 ,  A61P3/08 ,  A61P9/00 ,  A61P43/00 ,  C07K14/54 ,  A61K38/20

    CPC分类号： C07K14/5443 ,  A61K38/30

    摘要： Compositions and methods for stimulating muscle growth or differentiation in a vertebrate are disclosed. Such compositions include a muscle-trophic amount of interleukin-15 and can be used to treat a variety of conditions including disuse atrophy, wasting, various age-related disorders, secondary effects of diabetes, including glucose-intolerance, as well as muscular dystrophy, rhabdomyosarcoma and congestive heart failure. The compositions and methods of the invention find agricultural use in increasing the efficiency of meat and milk production of farm animals.

    摘要翻译： 公开了用于刺激脊椎动物中的肌肉生长或分化的组合物和方法。 这样的组合物包括肌肉营养量的白细胞介素-15，并且可以用于治疗多种病症，包括消除萎缩，浪费，各种年龄相关疾病，糖尿病的继发性影响，包括葡萄糖耐量不足，以及肌营养不良症， 横纹肌肉瘤和充血性心力衰竭。 本发明的组合物和方法发现农业用于提高农场动物肉和牛奶的生产效率。

    Treatment of bacterial diseases with granulocyte-macrophage colony stimulating factor
    19.
    发明授权
    Treatment of bacterial diseases with granulocyte-macrophage colony stimulating factor 失效
    用粒细胞巨噬细胞集落刺激因子治疗细菌性疾病

    公开(公告)号：US5162111A

    公开(公告)日：1992-11-10

    申请号：US892123

    申请日：1986-07-30

    申请人： Kenneth H. Grabstein ,  Philip J. Morrissey

    发明人： Kenneth H. Grabstein ,  Philip J. Morrissey

    IPC分类号： A61K38/00 ,  A61P31/04 ,  C07K14/535

    CPC分类号： C07K14/535 ,  A61K38/00 ,  Y10S930/145

    摘要： Subjects suffering from infectious diseases are treated by direct administration of therapeutically-effective quantities of granulocyte-macrophage colony stimulating factor employed by itself or in conjunction with an antibiotic or a sulfonamide or other immunologically effective therapeutic agents. Homogeneous granulocyte-macrophage colony stimulating factor for use in treatment in bacterial diseases is prepared by recombinant DNA techniques and then purified to homogeneity by reverse phase high-performance liquid chromatography so that it may be safely administered to subject's suffering from infectious diseases.

    摘要翻译： 患有感染性疾病的受试者通过直接施用治疗有效量的粒细胞 - 巨噬细胞集落刺激因子来治疗，所述粒细胞 - 巨噬细胞集落刺激因子本身或与抗生素或磺酰胺或其他免疫学上有效的治疗剂一起使用。 通过重组DNA技术制备用于细菌性疾病治疗的均匀粒细胞 - 巨噬细胞集落刺激因子，然后通过反相高效液相色谱纯化至均匀，从而可以安全地施用受试者感染性疾病。