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公开(公告)号：US08568706B2
公开(公告)日：2013-10-29
申请号：US12610909
申请日：2009-11-02
申请人： Kenneth H. Grabstein , Aijun Wang , Natalie Winblade Nairn , Thomas James Graddis , Stephen McCraith , Deepshikha Datta
发明人： Kenneth H. Grabstein , Aijun Wang , Natalie Winblade Nairn , Thomas James Graddis , Stephen McCraith , Deepshikha Datta
CPC分类号： C07K14/565 , A61K38/193 , A61K38/21 , A61K38/215 , A61K47/60 , C12P21/00 , C12P21/02 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
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公开(公告)号：US20100254943A1
公开(公告)日：2010-10-07
申请号：US12610909
申请日：2009-11-02
申请人： Kenneth H. Grabstein , Aijun Wang , Natalie Winblade Nairn , Thomas James Graddis , Stephen McCraith , Deepshikha Datta
发明人： Kenneth H. Grabstein , Aijun Wang , Natalie Winblade Nairn , Thomas James Graddis , Stephen McCraith , Deepshikha Datta
IPC分类号： A61K38/21 , C12P21/00 , C07H21/00 , C07K2/00 , C07K16/00 , A61K38/22 , A61K38/23 , A61K38/28
CPC分类号： C07K14/565 , A61K38/193 , A61K38/21 , A61K38/215 , A61K47/60 , C12P21/00 , C12P21/02 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
摘要翻译： 本发明提供通过用非天然氨基酸修饰来鉴定，修饰和产生修饰的靶分子（包括治疗分子）的组合物和方法。 本发明的某些方面包括向目标分子添加化学部分的方法和由其产生的组合物。 本发明的某些方面还涉及用于鉴定，修饰和产生本文所述的修饰的靶分子的试剂盒。
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公开(公告)号：US07829659B2
公开(公告)日：2010-11-09
申请号：US12105154
申请日：2008-04-17
IPC分类号： C07K1/107 , C07K14/105 , C07K14/565 , C07K14/535 , C08G65/00
CPC分类号： C12P21/02 , A61K38/00 , A61K47/60 , C07K1/006 , C07K1/1077 , C07K14/565 , C07K14/72 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
摘要翻译： 本发明提供通过用非天然氨基酸修饰来鉴定，修饰和产生修饰的靶分子（包括治疗分子）的组合物和方法。 本发明的某些方面包括向目标分子添加化学部分的方法和由其产生的组合物。 本发明的某些方面还涉及用于鉴定，修饰和产生本文所述的修饰的靶分子的试剂盒。
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公开(公告)号：US20080214439A1
公开(公告)日：2008-09-04
申请号：US12105155
申请日：2008-04-17
CPC分类号： C12P21/02 , A61K38/00 , C07K14/565 , C07K2319/22 , C07K2319/30 , C07K2319/40 , C07K2319/55 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
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公开(公告)号：US20080200641A1
公开(公告)日：2008-08-21
申请号：US12105154
申请日：2008-04-17
IPC分类号： C07K1/107 , C07K14/505 , C07K14/565 , C07K14/535 , C08G65/00
CPC分类号： C12P21/02 , A61K38/00 , A61K47/60 , C07K1/006 , C07K1/1077 , C07K14/565 , C07K14/72 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
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公开(公告)号：US20080125347A1
公开(公告)日：2008-05-29
申请号：US11743608
申请日：2007-05-02
IPC分类号： A61K38/00 , C12P21/00 , C12N15/11 , C12N15/13 , C12N15/63 , C07K1/00 , C12N15/19 , C12N15/18
CPC分类号： C12P21/02 , A61K38/00 , C07K14/565 , C07K2319/22 , C07K2319/30 , C07K2319/40 , C07K2319/55 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
摘要翻译： 本发明提供通过用非天然氨基酸修饰来鉴定，修饰和产生修饰的靶分子（包括治疗分子）的组合物和方法。 本发明的某些方面包括向目标分子添加化学部分的方法和由其产生的组合物。 本发明的某些方面还涉及用于鉴定，修饰和产生本文所述的修饰的靶分子的试剂盒。
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公开(公告)号：US06800746B2
公开(公告)日：2004-10-05
申请号：US09759143
申请日：2001-01-12
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5156 , A61K2039/53 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
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公开(公告)号：US06512094B1
公开(公告)日：2003-01-28
申请号：US09593793
申请日：2000-06-13
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C07K100
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：USD1036624S1
公开(公告)日：2024-07-23
申请号：US29937679
申请日：2024-04-16
申请人： Aijun Wang
设计人： Aijun Wang
摘要： FIG. 1 is a front, right, and top perspective view of a fire hose nozzle, showing my new design;
FIG. 2 is a rear, left, and bottom perspective view thereof;
FIG. 3 is a front elevational view thereof;
FIG. 4 is a rear elevational view thereof;
FIG. 5 is a left elevational view thereof;
FIG. 6 is a right elevational view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The broken lines in the drawings depict portions of the fire hose nozzle and form no part of the claimed design.-
公开(公告)号：US20060269532A1
公开(公告)日：2006-11-30
申请号：US11344932
申请日：2006-02-01
申请人： Jiangchun Xu , Davin Dillon , Jennifer Mitcham , Susan Harlocker , Yuqiu Jiang , Robert Henderson , Michael Kalos , Gary Fanger , Marc Retter , John Stolk , Craig Day , Thomas Vedvick , Darrick Carter , Samuel Li , Aijun Wang , Yasir Skeiky , William Hepler , John Hural , Patricia McNeill , Raymond Houghton , Carlota Vinals y de Bassols , Teresa Foy , Yoshihiro Watanabe , Madeleine Meagher , Ta Deng
发明人： Jiangchun Xu , Davin Dillon , Jennifer Mitcham , Susan Harlocker , Yuqiu Jiang , Robert Henderson , Michael Kalos , Gary Fanger , Marc Retter , John Stolk , Craig Day , Thomas Vedvick , Darrick Carter , Samuel Li , Aijun Wang , Yasir Skeiky , William Hepler , John Hural , Patricia McNeill , Raymond Houghton , Carlota Vinals y de Bassols , Teresa Foy , Yoshihiro Watanabe , Madeleine Meagher , Ta Deng
CPC分类号： C07K14/4748 , A61K2039/505 , C07K16/3069 , C07K2317/34 , C12Q1/68 , C12Q1/6886 , G01N33/57434
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
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