-
公开(公告)号：US08568706B2
公开(公告)日：2013-10-29
申请号：US12610909
申请日：2009-11-02
申请人： Kenneth H. Grabstein , Aijun Wang , Natalie Winblade Nairn , Thomas James Graddis , Stephen McCraith , Deepshikha Datta
发明人： Kenneth H. Grabstein , Aijun Wang , Natalie Winblade Nairn , Thomas James Graddis , Stephen McCraith , Deepshikha Datta
CPC分类号： C07K14/565 , A61K38/193 , A61K38/21 , A61K38/215 , A61K47/60 , C12P21/00 , C12P21/02 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
-
公开(公告)号：US20100254943A1
公开(公告)日：2010-10-07
申请号：US12610909
申请日：2009-11-02
申请人： Kenneth H. Grabstein , Aijun Wang , Natalie Winblade Nairn , Thomas James Graddis , Stephen McCraith , Deepshikha Datta
发明人： Kenneth H. Grabstein , Aijun Wang , Natalie Winblade Nairn , Thomas James Graddis , Stephen McCraith , Deepshikha Datta
IPC分类号： A61K38/21 , C12P21/00 , C07H21/00 , C07K2/00 , C07K16/00 , A61K38/22 , A61K38/23 , A61K38/28
CPC分类号： C07K14/565 , A61K38/193 , A61K38/21 , A61K38/215 , A61K47/60 , C12P21/00 , C12P21/02 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
摘要翻译： 本发明提供通过用非天然氨基酸修饰来鉴定，修饰和产生修饰的靶分子（包括治疗分子）的组合物和方法。 本发明的某些方面包括向目标分子添加化学部分的方法和由其产生的组合物。 本发明的某些方面还涉及用于鉴定，修饰和产生本文所述的修饰的靶分子的试剂盒。
-
公开(公告)号：US07632492B2
公开(公告)日：2009-12-15
申请号：US11743608
申请日：2007-05-02
申请人： Kenneth H. Grabstein , Andrea Wang , Natalie Winblade Nairn , Stephen McCraith , Deepshikha Datta
发明人： Kenneth H. Grabstein , Andrea Wang , Natalie Winblade Nairn , Stephen McCraith , Deepshikha Datta
CPC分类号： C12P21/02 , A61K38/00 , C07K14/565 , C07K2319/22 , C07K2319/30 , C07K2319/40 , C07K2319/55 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
摘要翻译： 本发明提供通过用非天然氨基酸修饰来鉴定，修饰和产生修饰的靶分子（包括治疗分子）的组合物和方法。 本发明的某些方面包括向目标分子中加入化学部分的方法和由其产生的组合物。 本发明的某些方面还涉及用于鉴定，修饰和产生本文所述的修饰的靶分子的试剂盒。
-
公开(公告)号：US07829659B2
公开(公告)日：2010-11-09
申请号：US12105154
申请日：2008-04-17
IPC分类号： C07K1/107 , C07K14/105 , C07K14/565 , C07K14/535 , C08G65/00
CPC分类号： C12P21/02 , A61K38/00 , A61K47/60 , C07K1/006 , C07K1/1077 , C07K14/565 , C07K14/72 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
摘要翻译： 本发明提供通过用非天然氨基酸修饰来鉴定，修饰和产生修饰的靶分子（包括治疗分子）的组合物和方法。 本发明的某些方面包括向目标分子添加化学部分的方法和由其产生的组合物。 本发明的某些方面还涉及用于鉴定，修饰和产生本文所述的修饰的靶分子的试剂盒。
-
公开(公告)号：US20080214439A1
公开(公告)日：2008-09-04
申请号：US12105155
申请日：2008-04-17
CPC分类号： C12P21/02 , A61K38/00 , C07K14/565 , C07K2319/22 , C07K2319/30 , C07K2319/40 , C07K2319/55 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
-
公开(公告)号：US20080200641A1
公开(公告)日：2008-08-21
申请号：US12105154
申请日：2008-04-17
IPC分类号： C07K1/107 , C07K14/505 , C07K14/565 , C07K14/535 , C08G65/00
CPC分类号： C12P21/02 , A61K38/00 , A61K47/60 , C07K1/006 , C07K1/1077 , C07K14/565 , C07K14/72 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
-
公开(公告)号：US20080125347A1
公开(公告)日：2008-05-29
申请号：US11743608
申请日：2007-05-02
IPC分类号： A61K38/00 , C12P21/00 , C12N15/11 , C12N15/13 , C12N15/63 , C07K1/00 , C12N15/19 , C12N15/18
CPC分类号： C12P21/02 , A61K38/00 , C07K14/565 , C07K2319/22 , C07K2319/30 , C07K2319/40 , C07K2319/55 , Y02A50/463
摘要： The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.
摘要翻译： 本发明提供通过用非天然氨基酸修饰来鉴定，修饰和产生修饰的靶分子（包括治疗分子）的组合物和方法。 本发明的某些方面包括向目标分子添加化学部分的方法和由其产生的组合物。 本发明的某些方面还涉及用于鉴定，修饰和产生本文所述的修饰的靶分子的试剂盒。
-
公开(公告)号：US07235240B2
公开(公告)日：2007-06-26
申请号：US11221399
申请日：2005-09-07
CPC分类号： C07K16/244 , A61K38/00 , A61K47/60 , C07K14/5443 , C07K2317/76
摘要： Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are incapable of transducing a signal through either the β- or γ-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the β- or γ-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease,
摘要翻译： 公开了哺乳动物白细胞介素-15（“IL-15”）的拮抗剂，并且包括IL-15和修饰的IL-15分子的突变蛋白，其各自能够结合IL-15Rα-亚基并且不能通过 IL-15受体复合物的β亚基或γ亚基。 还包括针对IL-15的单克隆抗体，其阻止IL-15通过IL-15受体复合物的β亚基或γ亚基进行信号转导。 公开了治疗各种疾病状态的方法，包括治疗同种异体移植排斥和移植物抗宿主病，
-
公开(公告)号：US06177079B1
公开(公告)日：2001-01-23
申请号：US09196427
申请日：1998-11-20
IPC分类号： A61K39395
CPC分类号： C07K16/244 , A61K38/00 , A61K2039/505 , C07K14/5443
摘要： Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15R&agr;-subunit and that are incapable of transducing a signal through either the &bgr;- or &ggr;-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the B- or &ggr;subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed. including treating allograft rejection and graft-versus-host disease.
摘要翻译： 公开了哺乳动物白细胞介素-15（“IL-15”）的拮抗剂，并且包括IL-15和修饰的IL-15分子的突变蛋白，其各自能够结合IL-15Rα-亚基并且不能通过 IL-15受体复合物的β亚基或γ亚基。 还包括针对IL-15的单克隆抗体，其阻止IL-15通过IL-15受体复合物的B-或gammasubunits进行信号转导。 公开了治疗各种疾病状态的方法。 包括治疗同种异体移植排斥和移植物抗宿主病。
-
公开(公告)号：US6013480A
公开(公告)日：2000-01-11
申请号：US134132
申请日：1998-08-14
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K47/48 , A61P37/06 , C07K14/54 , C07K16/24 , C07K16/42 , C07K19/00 , C12N1/19 , C12N15/24 , C12P21/02 , C12P21/08 , C12R1/865 , C12P21/06 , C07H21/02 , C12N5/00 , C12N15/00
CPC分类号： C07K16/244 , C07K14/5443 , A61K2039/505 , A61K38/00
摘要： Antagonists of mammalian interleukin-15 ("IL-15") are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15R.alpha.-subunit and that are incapable of transducing a signal through either the .beta.- or .gamma.-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the .beta.- or .gamma.-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease.
摘要翻译： 公开了哺乳动物白细胞介素-15（“IL-15”）的拮抗剂，并且包括IL-15和修饰的IL-15分子的突变蛋白，其各自能够结合IL-15Rα-亚基并且不能转导信号 通过IL-15受体复合物的β或γ亚基。 还包括针对IL-15的单克隆抗体，其阻止IL-15通过IL-15受体复合物的β或γ亚基进行信号转导。 公开了治疗各种疾病状态的方法，包括治疗同种异体移植排斥和移植物抗宿主病。
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.042 秒)
