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公开(公告)号:US12097984B2
公开(公告)日:2024-09-24
申请号:US17508812
申请日:2021-10-22
Applicant: Dr. Py Institute, LLC
Inventor: Daniel Py
CPC classification number: B65B3/003 , A61J1/2096 , A61M5/32 , B65B39/004 , B65B39/12
Abstract: A needle has a hollow shaft, a tip formed at one end of the shaft, one or more ports in fluid communication with the interior of the hollow shaft, and a closure. The closure and/or the shaft is movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s).
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公开(公告)号:US11419987B2
公开(公告)日:2022-08-23
申请号:US16391872
申请日:2019-04-23
Applicant: Dr. Py Institute LLC
Inventor: Daniel Py
IPC: A61M5/31 , A61M5/315 , B05B11/00 , G01F11/02 , B65D83/14 , A61M5/178 , A61J7/00 , A61M5/20 , B05B9/04
Abstract: A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber.
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公开(公告)号:US20190247588A1
公开(公告)日:2019-08-15
申请号:US16391872
申请日:2019-04-23
Applicant: Dr. Py Institute LLC
Inventor: Daniel Py
CPC classification number: A61M5/31593 , A61J7/0053 , A61M5/1782 , A61M5/204 , A61M2005/3126 , A61M2005/3128 , B05B9/0426 , B05B11/00416 , B05B11/007 , B05B11/0072 , B05B11/3015 , B05B11/3028 , B05B11/3064 , B05B11/3077 , B65D83/7535 , G01F11/02 , G01F11/025 , G01F11/027 , G01F11/028
Abstract: A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber.
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14.
公开(公告)号:US20190168930A1
公开(公告)日:2019-06-06
申请号:US16194492
申请日:2018-11-19
Applicant: Dr. Py Institute LLC
Inventor: Daniel Py
Abstract: A device includes a first part having a co-molded first support, valve cover and elastic actuator, and a second part having an injection molded second support, valve seat, and variable-volume storage chamber pre-form. The pre-form is blow molded into a flexible pouch defining the variable-volume storage chamber. The one-way valve includes a semi-annular, curvilinear, relatively rigid valve seat defining axially-extending, opposing first marginal portions, and an axially-extending first mid-portion angularly extending between the opposing first marginal portions. A flexible valve member is superimposed on the valve seat and defines axially-extending, opposing second marginal portions fixedly secured on or adjacent to respective first marginal portions of the valve seat, and an axially-extending second mid-portion angularly extending between the opposing first marginal portions and superimposed onto the first mid-portion of the valve seat. The flexible valve cover and valve seat form a normally closed axially and angularly extending valve seam therebetween.
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公开(公告)号:US20180353378A1
公开(公告)日:2018-12-13
申请号:US15944094
申请日:2018-04-03
Applicant: Dr. Py Institute LLC
Inventor: Daniel Py
IPC: A61J1/14
Abstract: A septum is penetrable by a needle for decontamination by physical interaction. The septum can include a peripheral portion, an exterior surface], and an interior surface. A penetration portion extends between the exterior and interior surfaces, is spaced inwardly of the peripheral portion, and is penetrable by the needle or other penetrating element. A flex portion is located between the penetration portion and the peripheral portion. A thicker portion extends between the flex portion and the penetration portion, and defines an increased thickness between the exterior and interior surfaces relative to the flex portion. The flex portion is flexible inwardly relative to the peripheral portion during penetration of the penetration portion by a needle or other penetrating element. The penetration portion physically interacts with and decontaminates the needle when it penetrates the septum. The septum may also reduce or prevent retrograde contamination when the needle is withdrawn.
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公开(公告)号:US10131474B2
公开(公告)日:2018-11-20
申请号:US14680393
申请日:2015-04-07
Applicant: Dr. Py Institute LLC
Inventor: Daniel Py
IPC: B65D47/20 , B65B55/08 , B65D51/00 , B65B51/02 , B29B11/08 , B65D83/00 , F16K15/14 , B05B11/04 , B29C73/02 , B29B11/14 , B29C49/06 , B29K23/00 , B29K67/00 , B29K105/00
Abstract: A device includes a first part having a co-molded first support, valve cover and elastic actuator, and a second part having an injection molded second support, valve seat, and variable-volume storage chamber pre-form. The pre-form is blow molded into a flexible pouch defining the variable-volume storage chamber. The one-way valve includes a semi-annular, curvilinear, relatively rigid valve seat defining axially-extending, opposing first marginal portions, and an axially-extending first mid-portion angularly extending between the opposing first marginal portions. A flexible valve member is superimposed on the valve seat and defines axially-extending, opposing second marginal portions fixedly secured on or adjacent to respective first marginal portions of the valve seat, and an axially-extending second mid-portion angularly extending between the opposing first marginal portions and superimposed onto the first mid-portion of the valve seat. The flexible valve cover and valve seat form a normally closed axially and angularly extending valve seam therebetween.
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公开(公告)号:US09931274B2
公开(公告)日:2018-04-03
申请号:US15267131
申请日:2016-09-15
Applicant: Dr. Py Institute, LLC
Inventor: Daniel Py
CPC classification number: A61J1/1406
Abstract: A septum is penetrable by a needle for decontamination by physical interaction. The septum can include a peripheral portion, an exterior surface], and an interior surface. A penetration portion extends between the exterior and interior surfaces, is spaced inwardly of the peripheral portion, and is penetrable by the needle or other penetrating element. A flex portion is located between the penetration portion and the peripheral portion. A thicker portion extends between the flex portion and the penetration portion, and defines an increased thickness between the exterior and interior surfaces relative to the flex portion. The flex portion is flexible inwardly relative to the peripheral portion during penetration of the penetration portion by a needle or other penetrating element. The penetration portion physically interacts with and decontaminates the needle when it penetrates the septum. The septum may also reduce or prevent retrograde contamination when the needle is withdrawn.
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18.
公开(公告)号:US20180022515A1
公开(公告)日:2018-01-25
申请号:US15608864
申请日:2017-05-30
Applicant: Dr. Py Institute LLC
Inventor: Daniel Py
IPC: B65D47/24 , B29C47/00 , B65D47/32 , B05B11/00 , B65D23/02 , B29L31/00 , B29C47/06 , B29C49/04 , B29L9/00
CPC classification number: B65D47/24 , B05B11/3028 , B29C48/08 , B29C48/09 , B29C48/10 , B29C48/21 , B29C48/23 , B29C49/04 , B29L2009/00 , B29L2031/7158 , B65D23/02 , B65D47/205 , B65D47/32
Abstract: A device comprises a first portion including a first polymer, and a second portion that is relatively flexible in comparison to the first portion and includes a second polymer that is substantially not bondable to the first polymer. A chamber of the device is hermetically sealable with respect to ambient atmosphere and is defined by (i) an interior of the second portion, and/or (ii) a space formed between the first and second portions. A third portion of the device includes a third polymer that is bondable to the first and second polymers and fixedly secures the first and second portions to each other.
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公开(公告)号:US20170203267A1
公开(公告)日:2017-07-20
申请号:US15410513
申请日:2017-01-19
Applicant: Dr. Py Institute LLC
Inventor: Daniel Py , Debashis Sahoo
CPC classification number: B01F5/0062 , B01F3/0861 , B01F3/20 , B01F5/0057 , B01F5/0471 , B01F15/00071 , B01F15/0245 , B01F2005/002 , B01F2215/0014 , B01F2215/0022 , B01F2215/0031 , B01F2215/0032
Abstract: An outer shell and nozzle portion define therebetween a swirl chamber having a plurality of inlet flow paths and an outlet flow path. The swirl chamber may receive a plurality of substances or components from separate sources, to mix the plurality of substances in the swirl chamber, and to deliver the mixed substances or formulation through an outlet, e.g., to a connector. The substances may be sterile, and the entire flow path from the substance sources to the container may be sterile and aseptically sealed from ambient atmosphere. The outer shell and nozzle portion may be constructed of plastic or other disposable materials. The swirl chamber may be constructed to optimize the mixing of the substances through control of the velocity by which each substance enters the swirl chamber.
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公开(公告)号:US09415885B2
公开(公告)日:2016-08-16
申请号:US14208030
申请日:2014-03-13
Applicant: Dr. Py Institute, LLC
Inventor: Daniel Py
CPC classification number: A61J1/2051 , A61J1/2096 , B65B3/003 , B65B7/161 , B65D11/04 , B65D71/502
Abstract: A device that has a device body defining an opening at one end thereof, a storage chamber within the device body for storing multiple doses of a substance therein, and a sliding stopper, sealing engageable with the device body, through which the chamber is filled. The stopper has a body and a flexible portion, which may be in the form of a plurality of flexible members, extending therefrom. The flexible portion or members are movable between first and second positions. In the first position, during filling, the portion or members are substantially laterally extending from the stopper body and engaging the opening of the device body. Accordingly, the axial position of the stopper with respect to the device body is secured during filling of the chamber therethrough. In the second position, after filling, the portion or members are substantially axially-extending from the stopper body and disengaged from the rim or opening of the device body. Accordingly, the stopper is axially slideable through the body.
Abstract translation: 一种装置,其具有在其一端限定开口的装置主体,在装置主体内用于储存多个剂量的物质的储存室,以及滑动止动件,可与装置主体接合,通过该装置主体填充该容器。 止动器具有主体和柔性部分,其可以是从其延伸的多个柔性构件的形式。 柔性部分可在第一和第二位置之间移动。 在第一位置,在填充期间,该部分或部件基本上从止动体横向延伸并与装置主体的开口接合。 因此,塞子相对于装置主体的轴向位置在腔室通过其的填充期间被固定。 在第二位置,在填充之后,部分或部件基本上从止动体轴向延伸并与装置主体的边缘或开口脱离。 因此,止动件可轴向滑动通过本体。
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