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    DEVICE SUITABLE FOR VACUUM ASSISTED FILTRATION
    11.
    发明申请
    DEVICE SUITABLE FOR VACUUM ASSISTED FILTRATION 有权

    公开(公告)号：US20210299614A1

    公开(公告)日：2021-09-30

    申请号：US16328502

    申请日：2017-10-05

    Applicant: EMD Millipore Corporation

    Inventor： Christopher A. Scott ,  Kurt Greenizen ,  Paul Sydlowski

    IPC: B01D63/08 ,  B01D61/18 ,  B01D61/20

    Abstract: A funnel-less filtration device that attaches directly to a storage container such as a cell culture media bottle. The device includes a filter collar containing one or more membranes, an inlet with a coupling device for attaching the filter device to a supply of liquid to be filtered, an outlet at a lower portion of the collar, a vacuum port in the collar below the membrane(s) and a filtered vent in the collar above the membrane(s). Optionally, the device may include a filtrate reservoir attached to the outlet, preferably by a threaded connection. Optionally, the upper opening to the filter collar is selectively and removably sealed with a lid until used. The lid is then removed the filter device inverted over a storage container such as cell culture media bottle and the two are attached via the upper opening of the filter collar. The assembly is then inverted so the supply container is above the filter device. Upon subjecting the sample in the bottle to a driving force such as vacuum, the sample flows through the filtration element, and into a filtrate reservoir below the outlet of the filter collar.

    Stirred Cell And Method of Using Same
    13.
    发明申请
    Stirred Cell And Method of Using Same 审中-公开
    搅拌细胞和使用方法

    公开(公告)号：US20160228870A1

    公开(公告)日：2016-08-11

    申请号：US14994402

    申请日：2016-01-13

    Applicant: EMD Millipore Corporation

    Inventor： Phillip Clark ,  Kurt Greenizen ,  John Doyle

    IPC: B01L3/00 ,  G01N1/40

    CPC classification number: G01N1/4005 ,  B01L3/502 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2200/085 ,  B01L2200/087 ,  B01L2300/042 ,  B01L2300/048 ,  B01L2300/049 ,  B01L2300/0681 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/0605 ,  B01L2400/0633 ,  B01L2400/065

    Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.

    Abstract translation: 流体容纳压力容器，其消除了存在于某些常规容器中的外部支撑壳体，并提供了改进的盖对体界面。 在某些实施例中，盖被螺纹并构造成与压力容器的主体螺纹接合，并且具有足够的结构完整性以承受装置中的压力而不需要支撑壳体。 在某些实施例中，提供了一种互锁机构，其在设备处于压力下时防止盖被打开（例如，从主体移除）。 在某些实施例中，泄压阀设置有预加载偏置机构以实现所需的压力释放速率。 该容器可用于样品制备，包括样品的纯化或浓缩，特别是蛋白质样品。

    All-In-One Sample Preparation Device And Method
    15.
    发明申请
    All-In-One Sample Preparation Device And Method 有权
    一体式样品制备装置及方法

    公开(公告)号：US20140017151A1

    公开(公告)日：2014-01-16

    申请号：US14031458

    申请日：2013-09-19

    Applicant: EMD Millipore Corporation

    Inventor： Christopher A. Scott ,  Timothy K. Nadler ,  Kurt Greenizen ,  Louis Bonhomme ,  Sara D. Gutierrez ,  Masaharu Mabuchi ,  David Briggs ,  Phillip Clark ,  Ralph T. Scaduto

    IPC: G01N1/34

    CPC classification number: G01N1/34 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2315/02 ,  B01L3/5021 ,  B01L3/5085 ,  B01L2300/0618 ,  B01L2300/0681 ,  C07K1/16 ,  C07K1/22 ,  G01N1/405 ,  G01N1/4077 ,  G01N2001/4088 ,  Y10T436/25375

    Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.

    Abstract translation: 允许完全结合，洗涤，洗脱，缓冲交换和浓缩过程的样品制备装置，在多个装置之间没有样品转移的情况下进行。 该装置包括储存器，用于保持色谱介质的柱，用于保持过滤装置的保持器区域和出口。 过滤装置插入到离心装置的保持器区域中，并且组件可以放置在可选的保持器中。 具有或不具有任选的保持器的组件可以放置在用于离心的常规离心管中。 整个结合，洗涤，洗脱，缓冲液交换和浓缩步骤可以在没有任何移液管转移（和相关样品损失）的情况下进行，样品制备装置也可用于结合和洗涤步骤，在这种情况下，过滤 设备不需要，并且用于缓冲区交换和集中步骤，在这种情况下不需要介质。

    Device suitable for vacuum assisted filtration
    16.
    发明授权
    Device suitable for vacuum assisted filtration 有权

    公开(公告)号：US11925904B2

    公开(公告)日：2024-03-12

    申请号：US16328502

    申请日：2017-10-05

    Applicant: EMD Millipore Corporation

    Inventor： Christopher A. Scott ,  Kurt Greenizen ,  Paul Sydlowski

    IPC: B01D63/08 ,  B01D61/18 ,  B01D61/20

    CPC classification number: B01D63/087 ,  B01D61/18 ,  B01D61/20 ,  B01D2201/204

    Abstract: A funnel-less filtration device that attaches directly to a storage container such as a cell culture media bottle. The device includes a filter collar containing one or more membranes, an inlet with a coupling device for attaching the filter device to a supply of liquid to be filtered, an outlet at a lower portion of the collar, a vacuum port in the collar below the membrane(s) and a filtered vent in the collar above the membrane(s). Optionally, the device may include a filtrate reservoir attached to the outlet, preferably by a threaded connection. Optionally, the upper opening to the filter collar is selectively and removably sealed with a lid until used. The lid is then removed the filter device inverted over a storage container such as cell culture media bottle and the two are attached via the upper opening of the filter collar. The assembly is then inverted so the supply container is above the filter device. Upon subjecting the sample in the bottle to a driving force such as vacuum, the sample flows through the filtration element, and into a filtrate reservoir below the outlet of the filter collar.

    Stirred cell and method of using same
    17.
    发明授权
    Stirred cell and method of using same 有权

    公开(公告)号：US10656060B2

    公开(公告)日：2020-05-19

    申请号：US16115762

    申请日：2018-08-29

    Applicant: EMD Millipore Corporation

    Inventor： Phillip Clark ,  Kurt Greenizen ,  John Doyle

    IPC: G01N1/40 ,  B01L3/00

    Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.

    All-in-one sample preparation device and method
    20.
    发明授权
    All-in-one sample preparation device and method 有权
    一体式样品制备装置及方法

    公开(公告)号：US09103756B2

    公开(公告)日：2015-08-11

    申请号：US14031458

    申请日：2013-09-19

    Applicant: EMD Millipore Corporation

    Inventor： Christopher A. Scott ,  Timothy K. Nadler ,  Kurt Greenizen ,  Louis Bonhomme ,  Sara D. Gutierrez ,  Masaharu Mabuchi ,  David Briggs ,  Phillip Clark ,  Ralph T. Scaduto

    IPC: G01N1/34 ,  G01N1/40 ,  B01L3/00 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  C07K1/22 ,  C07K1/16

    CPC classification number: G01N1/34 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2315/02 ,  B01L3/5021 ,  B01L3/5085 ,  B01L2300/0618 ,  B01L2300/0681 ,  C07K1/16 ,  C07K1/22 ,  G01N1/405 ,  G01N1/4077 ,  G01N2001/4088 ,  Y10T436/25375

    Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.

    Abstract translation: 允许完全结合，洗涤，洗脱，缓冲交换和浓缩过程的样品制备装置，在多个装置之间没有样品转移的情况下进行。 该装置包括储存器，用于保持色谱介质的柱，用于保持过滤装置的保持器区域和出口。 过滤装置插入到离心装置的保持器区域中，并且组件可以放置在可选的保持器中。 具有或不具有任选的保持器的组件可以放置在用于离心的常规离心管中。 整个结合，洗涤，洗脱，缓冲液交换和浓缩步骤可以在没有任何移液管转移（和相关样品损失）的情况下进行，样品制备装置也可用于结合和洗涤步骤，在这种情况下，过滤 设备不需要，并且用于缓冲区交换和集中步骤，在这种情况下不需要介质。

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