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公开(公告)号:US10385070B2
公开(公告)日:2019-08-20
申请号:US13398184
申请日:2012-02-16
申请人: Sara Sabina Hadida-Ruah , Mark Thomas Miller , Edward Adam Kallel , Brian Richard Bear , Vijayalaksmi Arumugam , Michael Paul Deninno , Jinglan Zhou , Johnny Uy , Bryan A. Frieman
发明人: Sara Sabina Hadida-Ruah , Mark Thomas Miller , Edward Adam Kallel , Brian Richard Bear , Vijayalaksmi Arumugam , Michael Paul Deninno , Jinglan Zhou , Johnny Uy , Bryan A. Frieman
IPC分类号: C07D519/00 , C07D495/10 , C07D491/10 , C07D491/20 , C07D498/08 , C07D491/107
摘要: The invention relates to chroman spirocyclic piperidine amide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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12.
公开(公告)号:US20120245136A1
公开(公告)日:2012-09-27
申请号:US13398184
申请日:2012-02-16
申请人: Sara Sabina HADIDA-RUAH , Mark Thomas Miller , Edward Adam Kallel , Brian Richard Bear , Vijayalaksmi Arumugam , Michael Paul Deninno , Jinglan Zhou , Johnny Uy , Bryan A. Frieman
发明人: Sara Sabina HADIDA-RUAH , Mark Thomas Miller , Edward Adam Kallel , Brian Richard Bear , Vijayalaksmi Arumugam , Michael Paul Deninno , Jinglan Zhou , Johnny Uy , Bryan A. Frieman
IPC分类号: A61K31/438 , C07D495/10 , C07D491/20 , A61K31/5377 , A61P25/02 , C12N5/071 , A61P29/00 , A61P25/00 , A61P25/06 , C07D491/107 , A61K31/519
CPC分类号: C07D519/00 , C07D491/107 , C07D491/20 , C07D495/10 , C07D498/08
摘要: The invention relates to chroman spirocyclic piperidine amide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的苯并二氢吡喃螺环哌啶酰胺衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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13.
公开(公告)号:US07999113B2
公开(公告)日:2011-08-16
申请号:US11503449
申请日:2006-08-11
申请人: Sarah Hadida-Ruah , Frederick Van Goor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
发明人: Sarah Hadida-Ruah , Frederick Van Goor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
IPC分类号: A61K31/426 , C07D277/44
CPC分类号: C07D417/14 , A61K31/427
摘要: The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
摘要翻译: 本发明涉及囊性纤维化跨膜电导调节剂(“CFTR”)的调节剂,其组合物及其方法。 本发明还涉及使用这种调节剂治疗CFTR介导的疾病的方法。
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14.
公开(公告)号:US20080161371A1
公开(公告)日:2008-07-03
申请号:US11503449
申请日:2006-08-11
申请人: Sarah Hadida-Ruah , Frederick Van Goor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
发明人: Sarah Hadida-Ruah , Frederick Van Goor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
IPC分类号: A61K31/427 , C07D277/20 , C12Q1/02 , C12N5/00 , A61P25/00 , A61P43/00
CPC分类号: C07D417/14 , A61K31/427
摘要: The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
摘要翻译: 本发明涉及囊性纤维化跨膜电导调节剂(“CFTR”)的调节剂,其组合物及其方法。 本发明还涉及使用这种调节剂治疗CFTR介导的疾病的方法。
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公开(公告)号:US20130296364A1
公开(公告)日:2013-11-07
申请号:US13936277
申请日:2013-07-08
IPC分类号: C07D405/12 , A61K31/4725 , A61K45/06
CPC分类号: A61K31/4725 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D217/22 , C07D401/04 , C07D405/12 , C07D405/14
摘要: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号:US20130178496A1
公开(公告)日:2013-07-11
申请号:US13778949
申请日:2013-02-27
申请人: Hayley Binch , Peter D.J. Grootenhuis , Sara S. Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T.D. Fanning
发明人: Hayley Binch , Peter D.J. Grootenhuis , Sara S. Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T.D. Fanning
IPC分类号: A61K31/4375 , C07D471/04
CPC分类号: A61K31/4375 , C07D471/04
摘要: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号:US08318733B2
公开(公告)日:2012-11-27
申请号:US13108077
申请日:2011-05-16
申请人: Sara Sabina Hadida-Ruah , Matthew Hamilton , Mark Thomas Miller , Peter Diederik Jan Grootenhuis , Jinglan Zhou , Brian Richard Bear , Jason McCartney
发明人: Sara Sabina Hadida-Ruah , Matthew Hamilton , Mark Thomas Miller , Peter Diederik Jan Grootenhuis , Jinglan Zhou , Brian Richard Bear , Jason McCartney
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4418 , A61K31/443
CPC分类号: C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号:US08227615B2
公开(公告)日:2012-07-24
申请号:US12410725
申请日:2009-03-25
申请人: Sara Hadida-Ruah , Mark Miller , Jinglan Zhou , Brian Bear , Peter Grootenhuis
发明人: Sara Hadida-Ruah , Mark Miller , Jinglan Zhou , Brian Bear , Peter Grootenhuis
IPC分类号: A61K31/44 , C07D405/00
CPC分类号: C07D213/74 , C07D213/75 , C07D405/12 , C07D405/14 , C07D413/14
摘要: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译: 本发明涉及ATP结合盒(“ABC”)转运体或其片段的调节剂,包括囊性纤维化跨膜电导调节剂(“CFTR”),其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号:US08101767B2
公开(公告)日:2012-01-24
申请号:US12351401
申请日:2009-01-09
申请人: Sara Hadida Ruah , Anna Hazlewood , Peter D. J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人: Sara Hadida Ruah , Anna Hazlewood , Peter D. J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC分类号: C07D215/38
CPC分类号: C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译: 本发明涉及ATP结合盒(“ABC”)转运蛋白或其片段的调节剂,包括囊性纤维化跨膜电导调节剂,其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号:US08012999B2
公开(公告)日:2011-09-06
申请号:US12782967
申请日:2010-05-19
申请人: Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Jinglan Zhou , Brian Richard Bear , Mark T. Miller , Jason McCartney
发明人: Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Jinglan Zhou , Brian Richard Bear , Mark T. Miller , Jason McCartney
IPC分类号: A61K31/443 , A61K31/4418
CPC分类号: C07D213/75 , C07D405/12 , C07D405/14
摘要: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒(“ABC”)转运蛋白或其片段的调节剂,包括囊性纤维化跨膜电导调节剂(“CFTR”)。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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