公开(公告)号：US11298310B2

公开(公告)日：2022-04-12

申请号：US16795488

申请日：2020-02-19

Applicant: Evolved By Nature, Inc.

Inventor： Gregory H. Altman ,  Rebecca L. Lacouture ,  Rachel Lee Dow ,  Rachel M. Lind ,  Dylan S. Haas

IPC: A61K9/08 ,  A61K8/02 ,  A61K38/01 ,  A61K8/64 ,  C07K1/12 ,  C07K14/435 ,  A61K38/00 ,  A61K8/98 ,  A61Q19/02 ,  A61K8/92 ,  A61K8/04 ,  A61K8/19 ,  A61K8/9789 ,  A61K8/9794 ,  A61K8/97 ,  A61K8/27 ,  A61K8/29 ,  A61K8/67 ,  A61K8/73 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A45D33/00 ,  A61K8/365 ,  A61K8/49

Abstract: A composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals.

公开(公告)号：US11260012B2

公开(公告)日：2022-03-01

申请号：US15543029

申请日：2016-01-12

Applicant: Evolved By Nature, Inc.

Inventor： Gregory H. Altman ,  Dylan S. Haas ,  Rebecca L. Lacouture

IPC: A61Q19/02 ,  A61Q17/04 ,  A61K47/42 ,  A61K47/22 ,  A61K31/522 ,  A61K9/70 ,  A61K9/00 ,  A61K8/92 ,  A61K8/67 ,  A61K8/368 ,  A61Q19/08 ,  A61K8/04 ,  A61K8/64 ,  A61K8/365 ,  A61K8/49 ,  A61Q19/00 ,  A61Q17/00 ,  A61K8/02 ,  C07K14/435 ,  A61K8/9789

Abstract: In some embodiments, a composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals. In some embodiments, a composition is disclosed that includes silk fibroin-based protein fragments and is suitable for use in consumer applications. In some embodiments, a preserved composition is disclosed that includes silk fibroin-based protein fragments. In some embodiments, a method of preserving a solution using silk fibroin-based protein fragments is disclosed.

公开(公告)号：US20190211498A1

公开(公告)日：2019-07-11

申请号：US16356550

申请日：2019-03-18

Applicant: Evolved by Nature, Inc.

Inventor： Gregory H. Altman ,  Enrico Mortarino

IPC: D06M15/15 ,  A41D13/00 ,  A61K8/64 ,  A61Q19/00 ,  D06N7/00 ,  A41D31/00

CPC classification number: D06M15/15 ,  A41D13/0015 ,  A41D31/00 ,  A61K8/64 ,  A61Q19/00 ,  D06M2200/50 ,  D06N7/00 ,  D06N2203/02 ,  D10B2401/02

Abstract: Silk performance apparel and methods of preparing the same are disclosed herein. In some embodiments, silk performance apparel includes textiles, fabrics, consumer products, and other materials that are coated with aqueous solutions of pure silk fibroin-based protein fragments. In some embodiments, coated apparel products exhibit surprisingly improved moisture management properties and increased resistance to microbial growth.

公开(公告)号：US12296067B2

公开(公告)日：2025-05-13

申请号：US17414752

申请日：2019-12-19

Applicant: Evolved by Nature, Inc.

Inventor： Gregory H. Altman ,  Rebecca L. Lacouture ,  Peng Xu ,  Erlei Jin ,  Carlos J. Bosques ,  Patrick Yacono ,  Patrik Johansson

IPC: A61L27/26 ,  A61K8/64 ,  A61K8/73 ,  A61K8/86 ,  A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61Q19/08

Abstract: Hyaluronic acid and silk fibroin or silk fibroin fragments tissue fillers and methods of making and using the same are provided herein. In some embodiments, the disclosure relates to a biocompatible tissue filler comprising silk fibroin or silk fibroin fragments, hyaluronic acid (HA), and polyethylene glycol (PEG) and/or polypropylene glycol (PPG), wherein a portion of the HA is modified or crosslinked by one or more linker moieties comprising one or more of polyethylene glycol (PEG), polypropylene glycol (PPG), and a secondary alcohol, wherein the linker moieties are attached to the HA at one end of the linker.

公开(公告)号：US20240263390A1

公开(公告)日：2024-08-08

申请号：US18605448

申请日：2024-03-14

Applicant: Evolved by Nature, Inc.

Inventor： Gregory H. Altman ,  Carlos J. Bosques ,  Enrico Mortarino

IPC: D06N3/12 ,  D06N3/14

CPC classification number: D06N3/126 ,  D06N3/128 ,  D06N3/14 ,  D06N2201/042 ,  D06N2201/06 ,  D06N2211/28

Abstract: This disclosure provides novel silk protein bonded layered or spun materials and processes that convert the waste leather materials into luxury fabrics exhibiting good dyeability, high brilliance, and excellent color fastness. Described herein is silk processed, coated, repaired, and/or infused faux or bonded leather, or faux or bonded leather articles, and methods of preparing the same.

公开(公告)号：US20230338614A1

公开(公告)日：2023-10-26

申请号：US18306965

申请日：2023-04-25

Applicant: Evolved by Nature, Inc.

Inventor： Gregory H. Altman ,  Peng Xu ,  Erlei Jin

IPC: A61L27/26 ,  A61L27/52 ,  A61L27/22 ,  A61L27/20

CPC classification number: A61L27/26 ,  A61L27/20 ,  A61L27/227 ,  A61L27/52 ,  A61L2300/402 ,  A61L2400/06 ,  A61L2430/34

Abstract: Hyaluronic acid and silk protein fragments based tissue fillers and methods of using the same are provided herein.

公开(公告)号：US11649585B2

公开(公告)日：2023-05-16

申请号：US16356550

申请日：2019-03-18

Applicant: Evolved by Nature, Inc.

Inventor： Gregory H. Altman ,  Enrico Mortarino

IPC: D06M15/15 ,  A41D13/00 ,  A61K8/64 ,  A61Q19/00 ,  D06N7/00 ,  A41D31/00 ,  A41D31/18

CPC classification number: D06M15/15 ,  A41D13/0015 ,  A41D31/00 ,  A41D31/185 ,  A61K8/64 ,  A61Q19/00 ,  D06N7/00 ,  D06M2200/50 ,  D06N2203/02 ,  D10B2401/02

Abstract: Silk performance apparel and methods of preparing the same are disclosed herein. In some embodiments, silk performance apparel includes textiles, fabrics, consumer products, and other materials that are coated with aqueous solutions of pure silk fibroin-based protein fragments. In some embodiments, coated apparel products exhibit surprisingly improved moisture management properties and increased resistance to microbial growth.

公开(公告)号：US20220177530A1

公开(公告)日：2022-06-09

申请号：US17598717

申请日：2020-03-27

Applicant: EVOLVED BY NATURE, INC.

Inventor： Gregory H. Altman

IPC: C07K14/435 ,  A61L27/22 ,  A61L27/26 ,  A61Q19/00 ,  A61K8/64

Abstract: Recombinant silk coated and/or infused materials and articles, and methods of preparing the same are disclosed herein. In some embodiments, articles include textiles, fabrics, consumer products, leather, and other materials that are coated with recombinant silk-based protein fragments, such as recombinant spider or silkworm silk-based protein fragments, having low, medium, and/or high molecular weight in various ratios. In some embodiments, articles and materials include dermal fillers and cosmetic materials such as moisturizers that include recombinant silk-based protein fragments, such as recombinant spider or silkworm silk-based protein fragments, having low, medium, and/or high molecular weight in various ratios.

公开(公告)号：US20200306163A1

公开(公告)日：2020-10-01

申请号：US16651648

申请日：2018-09-27

Applicant: EVOLVED BY NATURE, INC.

Inventor： Gregory H. Altman

IPC: A61K8/64 ,  A61K47/42 ,  A61K47/46

Abstract: Silk coated and/or infused performance materials and apparel, and methods of preparing the same are disclosed herein. In some embodiments, silk performance apparel includes textiles, fabrics, consumer products, leather, and other materials that are coated with aqueous solutions of recombinant silk-based protein fragments, such as recombinant spider silk-based protein fragments, having low, medium, and/or high molecular weight in various ratios.

公开(公告)号：US10588843B2

公开(公告)日：2020-03-17

申请号：US16453620

申请日：2019-06-26

Applicant: Evolved by Nature, Inc.

Inventor： Gregory H. Altman ,  Rebecca L. Horan ,  Rachel Lee Dow ,  Rachel M. Lind ,  Dylan S. Haas

IPC: A61K9/08 ,  A61K8/02 ,  A61K38/01 ,  A61K8/64 ,  C07K1/12 ,  C07K14/435 ,  A61K38/00 ,  A61K8/98 ,  A61Q19/02 ,  A61K8/92 ,  A61K8/04 ,  A61K8/19 ,  A61K8/27 ,  A61K8/29 ,  A61K8/67 ,  A61K8/73 ,  A61K8/97 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A45D33/00 ,  A61K8/365 ,  A61K8/49

Abstract: A composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals.