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公开(公告)号：US10457655B2
公开(公告)日：2019-10-29
申请号：US15786539
申请日：2017-10-17
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , David R. Lancia, Jr. , Hongbin Li , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Mark J. Tebbe
IPC: C07D295/192 , A61K31/4965 , A61P35/00 , C07D401/04 , C07D403/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D213/65 , C07D213/69 , C07D213/56 , C07D231/12 , C07D235/08 , C07D209/08 , C07D209/18 , C07D263/57 , C07D271/12 , C07D277/66 , C07D277/62 , C07D513/04 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D215/14 , C07D231/56 , C07D257/04 , C07D305/08 , A61K31/497 , C07D217/16
Abstract: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US10450286B2
公开(公告)日：2019-10-22
申请号：US16389286
申请日：2019-04-19
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , David R. Lancia, Jr. , Hongbin Li , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E. R. Schiller , Mark J. Tebbe
IPC: C07D295/192 , A61K31/4965 , A61P35/00 , C07D401/04 , C07D403/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D213/65 , C07D213/69 , C07D213/56 , C07D231/12 , C07D235/08 , C07D209/08 , C07D209/18 , C07D263/57 , C07D271/12 , C07D277/66 , C07D277/62 , C07D513/04 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K45/06 , C07D217/16 , A61K31/5025 , A61K31/506 , C07D305/08 , C07D257/04 , C07D231/56 , C07D215/14
Abstract: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US10377769B2
公开(公告)日：2019-08-13
申请号：US16029166
申请日：2018-07-06
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , Torsten Herbertz , Goss S. Kauffman , Katherine J. Kayser-Bricker , George P. Luke , Matthew W. Martin , David S. Millan , Shawn E. R. Schiller , Adam C. Talbot , Mark J. Tebbe
IPC: C07D498/04 , C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/4985 , A61K31/53 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D241/42 , C07D417/10 , C07D241/50 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/048 , C07D495/04 , A61K45/06 , A61K31/498 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/506 , A61K31/517 , A61K31/55 , A61K31/553
Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
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公开(公告)号：US20190241532A1
公开(公告)日：2019-08-08
申请号：US16383296
申请日：2019-04-12
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , David R. Lancia, Jr. , Hongbin Li , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Mark J. Tebbe
IPC: C07D295/192 , C07D213/65 , A61K31/4965 , C07D231/12 , C07D235/08 , C07D401/04 , C07D403/04 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/5025 , A61K31/506 , C07D209/08 , C07D417/04 , C07D213/69 , C07D305/08 , C07D213/56 , C07D513/04 , C07D277/66 , C07D277/62 , C07D209/18 , C07D495/04 , C07D271/12 , C07D491/048 , C07D263/57 , C07D487/04 , C07D257/04 , C07D471/04 , C07D417/12 , C07D413/12 , C07D405/12 , C07D231/56 , C07D215/14 , A61K45/06 , C07D217/16
Abstract: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
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Patent Agency Ranking
公开(公告)号：US11084831B1
公开(公告)日：2021-08-10
申请号：US16872743
申请日：2020-05-12
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , Torsten Herbertz , Goss S. Kauffman , Katherine J. Kayser-Bricker , George P. Luke , Matthew W. Martin , David S. Millan , Shawn E. R. Schiller , Adam C. Talbot , Mark J. Tebbe
IPC: C07D498/04 , A61K31/553 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/4985 , A61K31/53 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D241/42 , C07D417/10 , C07D241/50 , C07D417/14 , C07D451/04 , C07D487/04 , C07D487/08 , C07D491/048 , C07D495/04 , A61K45/06 , A61K31/498 , A61K31/5025 , A61K31/519 , C07D471/04 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/506 , A61K31/517 , A61K31/55 , C07D403/12
Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
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公开(公告)号：US10703764B2
公开(公告)日：2020-07-07
申请号：US16444032
申请日：2019-06-18
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , Torsten Herbertz , Goss S. Kauffman , Katherine J. Kayser-Bricker , George P. Luke , Matthew W. Martin , David S. Millan , Shawn E. R. Schiller , Adam C. Talbot , Mark J. Tebbe
IPC: C07D498/04 , C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/4985 , A61K31/53 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D241/42 , C07D417/10 , C07D241/50 , C07D417/14 , C07D451/04 , C07D487/04 , C07D487/08 , C07D491/048 , C07D495/04 , A61K45/06 , A61K31/498 , A61K31/5025 , A61K31/519 , C07D471/04 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/506 , A61K31/517 , A61K31/55 , A61K31/553
Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
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公开(公告)号：US20180370933A1
公开(公告)日：2018-12-27
申请号：US16119962
申请日：2018-08-31
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , David R. Lancia, JR. , Hongbin Li , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Mark J. Tebbe
IPC: C07D295/192 , C07D305/08 , A61K31/495 , C07D401/04 , C07D277/66 , C07D277/62 , C07D271/12 , C07D263/57 , C07D257/04 , C07D235/08 , C07D231/56 , C07D231/12 , C07D217/16 , C07D215/14 , C07D213/69 , C07D213/65 , C07D213/56 , C07D209/18 , C07D209/08 , A61K45/06 , A61K31/506 , A61K31/5025 , C07D513/04 , C07D495/04 , C07D491/048 , C07D487/04 , C07D471/04 , C07D417/12 , C07D417/04 , C07D413/12 , C07D405/12 , C07D403/04 , A61K31/4985 , A61K31/497 , A61K31/496 , A61K31/4965
CPC classification number: C07D295/192 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D209/08 , C07D209/18 , C07D213/56 , C07D213/65 , C07D213/69 , C07D215/14 , C07D217/16 , C07D231/12 , C07D231/56 , C07D235/08 , C07D257/04 , C07D263/57 , C07D271/12 , C07D277/62 , C07D277/66 , C07D305/08 , C07D401/04 , C07D403/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04 , A61K2300/00
Abstract: The present invention relates to compounds and compositions for inhibition of FASN, their synthesis, applications, and antidotes.
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公开(公告)号：US20180050997A1
公开(公告)日：2018-02-22
申请号：US15786539
申请日：2017-10-17
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , David R. Lancia, JR. , Hongbin Li , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Mark J. Tebbe
IPC: C07D295/192 , C07D213/65 , A61K31/4965 , C07D231/12 , C07D235/08 , C07D401/04 , C07D403/04 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/5025 , A61K31/506 , C07D209/08 , C07D417/04 , C07D213/69 , C07D305/08 , C07D213/56 , C07D513/04 , C07D277/66 , C07D277/62 , C07D209/18 , C07D495/04 , C07D271/12 , C07D491/048 , C07D263/57 , C07D487/04 , C07D257/04 , C07D471/04 , C07D417/12 , C07D413/12 , C07D405/12 , C07D231/56 , C07D215/14 , C07D217/16 , A61K45/06
Abstract: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US09422281B2
公开(公告)日：2016-08-23
申请号：US14546896
申请日：2014-11-18
Applicant: Forma Therapeutics, Inc.
Inventor： Kenneth W. Bair , Torsten Herbertz , Goss S. Kauffman , Katherine J. Kayser-Bricker , George P. Luke , Matthew W. Martin , David S. Millan , Shawn E. R. Schiller , Adam C. Talbot , Mark J. Tebbe
IPC: C07D241/12 , A61K31/53 , C07D471/04 , C07D403/04 , A61K31/498 , C07D405/14 , C07D417/14 , C07D417/10 , C07D241/42 , C07D409/14 , C07D405/06 , C07D413/14 , C07D413/04 , C07D401/04 , C07D403/14 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/551
CPC classification number: C07D498/04 , A61K31/498 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , C07D241/42 , C07D241/50 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/048 , C07D495/04 , A61K2300/00
Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) br’omodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
Abstract translation: 本发明涉及具有式（I）的可用于治疗癌症，炎性疾病，糖尿病和肥胖症的溴和额外末端（BET）葡萄糖胞吐酶抑制剂：其中X，Y，Z，R 1，R 2 ，R4和R7在本文中定义。
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