公开(公告)号：US20250011706A1

公开(公告)日：2025-01-09

申请号：US18894014

申请日：2024-09-24

Applicant: FUJIFILM CORPORATION

Inventor： Shinichi NAKAI ,  Hiroshi SAKUYAMA ,  Naoto TAKAHASHI

IPC: C12M1/36 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34

Abstract: A method including: connecting, through a coupling line, a culture section where a culture step, in which cells are cultured in a culture liquid stored in a culture tank and the cells are removed from the culture liquid to obtain a culture supernatant liquid containing a product of the cells, is performed and a purification section where a purification step, in which the product is purified from the culture supernatant liquid to obtain an active pharmaceutical ingredient of a biopharmaceutical, is performed, to allow the culture supernatant liquid to flow into the purification section from the culture section through the coupling line; connecting a flexible single-use tank having an accommodation capacity of 0.2 times to 10 times an amount of the culture liquid in the culture tank to a branch line provided between the culture section and the purification section; and temporarily storing the culture supernatant liquid in the tank.

公开(公告)号：US20210147781A1

公开(公告)日：2021-05-20

申请号：US17104094

申请日：2020-11-25

Applicant: FUJIFILM Corporation

Inventor： Shinichi NAKAI ,  Kosuke TANIGUCHI ,  Nobuyuki HARAGUCHI ,  Tsukasa ISHIHARA

IPC: C12M1/00 ,  C07K16/00

Abstract: Provide are a cell culture method which includes using a culture vessel which contains a cell suspension containing cells and discharging a gas including 30% by volume or more of oxygen into the cell suspension from a sparger disposed in the culture vessel to culture the cells, in which an average hole diameter in a gas discharge portion in the sparger is 1 μm or more and 300 μm or less, and a surface area A (m2) in the gas discharge portion in the sparger, a volume X (m3) of the cell suspension in the culture vessel, and a flow rate Q (m3/min) of the gas that is discharged from the sparger satisfy a specific relationship, a product producing method including the cell culture method, and a cell culture device that enables the cell culture method.

公开(公告)号：US20190322975A1

公开(公告)日：2019-10-24

申请号：US16460983

申请日：2019-07-02

Applicant: FUJIFILM CORPORATION

Inventor： Shinichi NAKAI ,  Yoichi NAGAI ,  Nobuyuki HARAGUCHI ,  Shigehisa SUGIYAMA

IPC: C12M1/00 ,  B01D61/14 ,  B01D61/18 ,  C12M1/26 ,  C12N5/00 ,  C12M1/12

Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 μm or smaller, and 0

公开(公告)号：US20180046299A1

公开(公告)日：2018-02-15

申请号：US15782296

申请日：2017-10-12

Applicant: FUJIFILM Corporation

Inventor： Shinichi NAKAI ,  Yuki MATSUNAMI ,  Reona IKEDA ,  Tadashi KURIKI

IPC: G06F3/041 ,  G06F3/044 ,  G02B5/30 ,  G02F1/1335 ,  G02F1/1333

CPC classification number: G06F3/0412 ,  B32B7/02 ,  B32B9/00 ,  B32B27/36 ,  G02B5/30 ,  G02B5/3033 ,  G02B5/3083 ,  G02F1/13338 ,  G02F1/133528 ,  G02F1/133602 ,  G02F1/13362 ,  G02F1/13363 ,  G06F3/041 ,  G06F3/044

Abstract: Provided are a transparent base material film laminate that is used by being arranged on the viewing side of a polarizing plate of an image display device having a backlight light source and the polarizing plate, the laminate having a first transparent base material film and a second transparent base material film, in which a Re of the first transparent base material film is 4,000 nm or more, the laminate is arranged for use such that an angle formed between a slow axis of the first transparent base material film and an absorption axis of the polarizing plate is 45°±20° and such that an angle formed between a slow axis of the second transparent base material film and the absorption axis of the polarizing plate is 90°±30° or 0°±30°, an angle formed between the slow axes of the first transparent base material film and the second transparent base material film is neither 0° nor 90°, and the second transparent base material film is used by being arranged on the viewing side with respect to the first transparent base material film.

公开(公告)号：US20150331282A1

公开(公告)日：2015-11-19

申请号：US14709910

申请日：2015-05-12

Applicant: FUJIFILM Corporation

Inventor： Naoyoshi YAMADA ,  Shinichi NAKAI ,  Maki MIFUNE

IPC: G02F1/1335 ,  G02F1/13363

CPC classification number: G02B5/3033 ,  G02F1/133528 ,  G02F1/133603 ,  G02F1/13363 ,  G02F2001/133614 ,  G02F2201/50

Abstract: A liquid crystal display device has a light source unit and a liquid crystal cell sandwiched by two polarizing plates. The light emitted by the light source unit has separated peaks in each of blue, green and red wavelength ranges. The green and red peaks have a full width at half maximum intensity of 20 nm or more. At least one of the polarizing plates has a polarizer and a protective film with a Re of 5,000 nm or more and low moisture permeability. The device exhibits excellent color reproducibility and prevents display nonuniformity under a high temperature and high humidity environment.

Abstract translation: 液晶显示装置具有由两个偏振片夹持的光源单元和液晶单元。 由光源单元发出的光在蓝色，绿色和红色波长范围中分离出峰。 绿色和红色的峰具有20nm或更大的半最大强度的全宽。 偏振板中的至少一个具有偏振器和Re为5000nm以上且透湿性低的保护膜。 该装置表现出优异的色彩再现性，防止在高温高湿环境下显示不均匀。