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207 条记录 (耗时 0.065 秒)

    Amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof
    15.
    发明授权
    Amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof 失效
    丙泊酚的氨基酸衍生前药，组合物，用途及其结晶形式

    公开(公告)号：US08067455B2

    公开(公告)日：2011-11-29

    申请号：US12572505

    申请日：2009-10-02

    申请人： Feng Xu ,  Mark A. Gallop ,  Vivek Sasikumar ,  Usha Dilip

    发明人： Feng Xu ,  Mark A. Gallop ,  Vivek Sasikumar ,  Usha Dilip

    IPC分类号： A61K31/415

    CPC分类号： C07C229/22

    摘要： The present invention provides a prodrug of propofol and crystalline forms thereof, methods of making the propofol prodrug and crystalline forms thereof, pharmaceutical compositions of the propofol prodrug and crystalline forms thereof, methods of using the propofol prodrug and crystalline forms thereof and pharmaceutical compositions thereof to treat diseases or disorders such as headache pain, post-chemotherapy or post-operative surgery nausea and vomiting, neurodegenerative disorders, and mood disorders.

    摘要翻译： 本发明提供异丙酚及其结晶形式的前药，制备异丙酚前药及其结晶形式的方法，异丙酚前药及其结晶形式的药物组合物，使用异丙酚前药及其结晶形式的方法及其药物组合物 治疗诸如头痛，化疗后或术后手术恶心和呕吐，神经变性障碍和情绪障碍的疾病或障碍。

    CONTROL CIRCUIT OF LIGHT-EMITTING ELEMENT
    16.
    发明申请
    CONTROL CIRCUIT OF LIGHT-EMITTING ELEMENT 有权
    发光元件的控制电路

    公开(公告)号：US20110266965A1

    公开(公告)日：2011-11-03

    申请号：US13096652

    申请日：2011-04-28

    申请人： Feng Xu ,  Yoshio Fujimura

    发明人： Feng Xu ,  Yoshio Fujimura

    IPC分类号： H05B37/02

    CPC分类号： H05B33/0815 ,  H05B33/0809

    摘要： A control circuit of a light-emitting element comprises a rectifying unit (30) which full-wave rectifies an alternating current power supply, a switching element (38), a reference voltage generating unit (40) which generates a reference voltage (Vref), and a comparator (42) which receives a voltage (Srec) rectified by the rectifying unit (30), compares a comparative voltage (Vcmp) corresponding to a current flowing to an LED (102) and the reference voltage (Vref), and controls switching of the switching element (38) according to a comparison result, wherein the reference voltage generating unit (40) comprises a voltage dividing circuit having a transistor (Q1) in which a resistance value between a source and a drain is changed according to the voltage rectified by the rectifying unit (30), and outputs, using the voltage dividing circuit, the reference voltage (Vref) according to the voltage (Srec) rectified by the rectifying unit (30).

    摘要翻译： 发光元件的控制电路包括对交流电源进行全波整流的整流单元（30），产生参考电压（Vref）的开关元件（38），参考电压产生单元（40） 和接收由整流单元（30）整流的电压（Srec）的比较器（42），比较与流过LED（102）的电流和基准电压（Vref）对应的比较电压（Vcmp），以及 根据比较结果控制开关元件（38）的切换，其中基准电压产生单元（40）包括具有晶体管（Q1）的分压电路，其中源极和漏极之间的电阻值根据 由整流单元（30）整流的电压，并且使用分压电路根据由整流单元（30）整流的电压（Srec）输出基准电压（Vref）。

    Shieled connector having leveling arrangement ensuring reliable interconnection
    17.
    发明授权
    Shieled connector having leveling arrangement ensuring reliable interconnection 有权

    公开(公告)号：US07997932B2

    公开(公告)日：2011-08-16

    申请号：US12807566

    申请日：2010-09-07

    申请人： Feng Xu

    发明人： Feng Xu

    IPC分类号： H01R13/648

    CPC分类号： H01R12/7052 ,  H01R12/707 ,  H01R2107/00

    摘要： A shield connector (100) includes a metallic shell (3) with a mating port (331) in communication with a mating receptacle with a tongue having a plurality of contact terminals (2) thereon. The contact terminals (2) include a plurality of solder tails (213, 223) extending out of the metallic shell (3). The metallic shell (3) defines a level arrangement (35) adjacent to the mating port (331) and defining a supporting plane coplanar to a mounting interface (5) of the shield connector (100).

    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    20.
    发明授权
    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use 失效
    氨基甲酸氨基甲酸烷基酯前药，合成和使用方法

    公开(公告)号：US07749985B2

    公开(公告)日：2010-07-06

    申请号：US12506961

    申请日：2009-07-21

    申请人： Mark A. Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    发明人： Mark A. Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    IPC分类号： A61K31/66 ,  C07F9/02

    CPC分类号： C07F9/301

    摘要： Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

    摘要翻译： 3-氨基丙基次膦酸的氨基甲酸烷基酯氨基甲酸酯前药及其类似物，3-氨基丙基次膦酸及其类似物的制备酰氨基烷基氨基甲酸酯前药的方法及其类似物，使用3-氨基丙基次膦酸及其类似物的酰氨基烷基氨基甲酸酯前药的方法和包含酰氨基烷基氨基甲酸酯前药3 - 氨基丙基次膦酸及其类似物用于治疗疾病或病症如轻度认知障碍，与阿尔茨海默氏病相关的认知障碍阿尔茨海默氏病，抑郁症，焦虑和癫痫。 还公开了适用于口服给药和缓释口服剂型的3-氨基丙基次膦酸的氨基氧基烷基氨基甲酸酯前药及其类似物。