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公开(公告)号:US09623348B2
公开(公告)日:2017-04-18
申请号:US14678841
申请日:2015-04-03
发明人: Brian McCarthy , Ben Ross-Johnsrud , Bart Lipkens
CPC分类号: B01D21/28 , B01D17/04 , B01D17/044 , B01J19/10 , B01J2219/0869 , B06B1/0644 , C12M35/04 , C12M47/02
摘要: An apparatus includes a flow chamber having at least one inlet and at least one outlet. At least one ultrasonic transducer is located on a wall of the flow chamber, which operates to create a multi-dimensional acoustic standing wave in the flow chamber. A reflector is located on the wall on the opposite side of the flow chamber from the at least one ultrasonic transducer. The reflector is formed from a thin structure that provides a pressure release boundary, such as a plastic film/air interface.
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公开(公告)号:US20160002070A1
公开(公告)日:2016-01-07
申请号:US14791115
申请日:2015-07-02
发明人: Bart Lipkens , Brian McCarthy , Jason Barnes , Dane Mealey , Ben Ross-Johnsrud , Walter M. Presz, JR. , Kedar Chitale
IPC分类号: C02F1/36
CPC分类号: B01D21/283 , B01D21/0045
摘要: An acoustophoresis device which includes a substantially vertical flow path of the fluid mixture in order to improve separation of particles/secondary fluid from a primary fluid is disclosed. The vertical flow path reduces velocity non-uniformities in the acoustic chamber resulting from gravity forces. The device includes an acoustic chamber in which multidimensional acoustic standing waves are generated. The fluid can be introduced into the acoustic chamber using a dump diffuser in which a plurality of inlets enter near the bottom of the acoustic chamber such that flow symmetry reduces both, gravity driven flow non-uniformities, and any flow interference effects between inlet mixture flow into the acoustic chamber and the continuous gravity driven particle cluster drop out.
摘要翻译: 公开了一种消声装置,其包括流体混合物的基本垂直的流动路径,以便改善颗粒/次级流体与初级流体的分离。 垂直流动路径降低了由重力引起的声室中的速度非均匀性。 该装置包括其中产生多维声驻波的声学室。 流体可以使用排放扩散器引入到声学室中,其中多个入口进入声室底部附近,使得流动对称性减小重力驱动的流动不均匀性,以及入口混合物流之间的任何流动干扰效应 进入声室,连续重力驱动的颗粒群落出。
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公开(公告)号:US20150191716A1
公开(公告)日:2015-07-09
申请号:US14592337
申请日:2015-01-08
发明人: Bart Lipkens , Brian McCarthy , Ben Ross-Johnsrud , Jason Barnes , Dane Mealey , Thomas J. Kennedy, III
IPC分类号: C12N13/00
CPC分类号: C12N13/00 , B01D21/283
摘要: An acoustophoresis device includes an acoustic chamber with a piezoelectric element located within its volume. The piezoelectric element vibrates and generates acoustic standing waves from both sides, so that particles can be separated from fluid passing through the acoustic chamber. This permits the element to be cooled more efficiently, reducing transient heat loads in the fluid traveling through the device.
摘要翻译: 声学输送装置包括具有位于其体积内的压电元件的声学室。 压电元件从两侧振动并产生声驻波,使得颗粒可以与通过声室的流体分离。 这允许元件被更有效地冷却,减少流过该装置的流体中的瞬时热负荷。
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公开(公告)号:US20220379310A1
公开(公告)日:2022-12-01
申请号:US17804211
申请日:2022-05-26
发明人: Brian Dutra , Christopher Jurkiewicz , Brian McCarthy , Richard Grant , Jeffrey King , Bart Lipkens , Yasser Ali , Stefano Berti Perez
摘要: A workstation for processing particles entrained in a fluid includes a consumable portion and a reusable portion. The consumable portion is mounted to the reusable portion to form a fluid chamber in which an acoustic wave can be generated. The consumable portion implements a closed, isolated fluid environment that is managed using components of the reusable portion, such as valves, sensors and pumps. The workstation can be operated to retain particles from the fluid via the acoustic wave and provide a new fluid media to the retained particles. Following processing, the consumable portion can be removed and discarded.
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公开(公告)号:US20170369865A1
公开(公告)日:2017-12-28
申请号:US15672288
申请日:2017-08-08
发明人: Bart Lipkens , Brian McCarthy , Ben Ross-Johnsrud , Jason Barnes , Dane Mealey , Thomas J. Kennedy, III
CPC分类号: C12N13/00 , B01D21/283
摘要: An acoustophoresis device includes an acoustic chamber with a piezoelectric element located within its volume. The piezoelectric element vibrates and generates acoustic standing waves from both sides, so that particles can be separated from fluid passing through the acoustic chamber. This permits the element to be cooled more efficiently, reducing transient heat loads in the fluid traveling through the device.
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公开(公告)号:US09827511B2
公开(公告)日:2017-11-28
申请号:US14791115
申请日:2015-07-02
发明人: Bart Lipkens , Brian McCarthy , Jason Barnes , Dane Mealey , Ben Ross-Johnsrud , Walter M. Presz, Jr. , Kedar Chitale
CPC分类号: B01D21/283 , B01D21/0045
摘要: An acoustophoresis device which includes a substantially vertical flow path of the fluid mixture in order to improve separation of particles/secondary fluid from a primary fluid is disclosed. The vertical flow path reduces velocity non-uniformities in the acoustic chamber resulting from gravity forces. The device includes an acoustic chamber in which multidimensional acoustic standing waves are generated. The fluid can be introduced into the acoustic chamber using a dump diffuser in which a plurality of inlets enter near the bottom of the acoustic chamber such that flow symmetry reduces both, gravity driven flow non-uniformities, and any flow interference effects between inlet mixture flow into the acoustic chamber and the continuous gravity driven particle cluster drop out.
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公开(公告)号:US09725710B2
公开(公告)日:2017-08-08
申请号:US14592337
申请日:2015-01-08
发明人: Bart Lipkens , Brian McCarthy , Ben Ross-Johnsrud , Jason Barnes , Dane Mealey , Thomas J. Kennedy, III
CPC分类号: C12N13/00 , B01D21/283
摘要: An acoustophoresis device includes an acoustic chamber with a piezoelectric element located within its volume. The piezoelectric element vibrates and generates acoustic standing waves from both sides, so that particles can be separated from fluid passing through the acoustic chamber. This permits the element to be cooled more efficiently, reducing transient heat loads in the fluid traveling through the device.
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公开(公告)号:US09675906B2
公开(公告)日:2017-06-13
申请号:US14870952
申请日:2015-09-30
发明人: Bart Lipkens , Jeff King , David Sokolowski , Anthony B. Masi , Brian T. Kennedy , Brian McCarthy , Benjamin Ross-Johnsrud , Jason Dionne , Dane Mealey , Jason Barnes
CPC分类号: B01D21/283 , B01D17/044 , B01D17/06 , B01D19/0078 , B06B1/06 , B06B1/0622 , B06B1/0644 , B06B2201/71 , C12M47/04 , C12N13/00
摘要: Acoustophoretic devices for separating particles from a non-flowing host fluid are disclosed. The devices include a substantially acoustically transparent container and a separation unit, with the container being placed within the separation unit. An ultrasonic transducer in the separation unit creates a planar or multi-dimensional acoustic standing wave within the container, trapping particles disposed within the non-flowing fluid and causing them to coalesce or agglomerate, then separate due to buoyancy or gravity forces.
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公开(公告)号:US20170088809A1
公开(公告)日:2017-03-30
申请号:US15284529
申请日:2016-10-03
发明人: Bart Lipkens , Thomas J. Kennedy, III , Jeffrey King , Jason Barnes , Brian McCarthy , Dane Mealey , Erik Miller , Walter M. Presz, JR. , Benjamin Ross-Johnsrud , John Rozembersky
CPC分类号: C12M33/08 , A61M1/3678 , B01D21/0045 , B01D21/283 , B06B1/0223 , B06B1/0276 , B06B1/06 , C12M47/02 , C12N13/00
摘要: An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.
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公开(公告)号:US20170081629A1
公开(公告)日:2017-03-23
申请号:US15371037
申请日:2016-12-06
发明人: Bart Lipkens , Jason Barnes , Dane Mealey , Walter M. Presz, JR. , Stanley Kowalski, III , Louis Masi , Thomas J. Kennedy, III , Brian McCarthy , Ben Ross-Johnsrud
CPC分类号: C12M47/02 , A61M1/3678 , B01D21/0045 , B01D21/283 , B06B1/06 , C12M33/08 , C12M47/10
摘要: An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.
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