摘要:
The present invention pertains to interferon-beta (IFN-beta) compositions comprising interferon-beta and a grafted poly(glutamic acid) polymer having an average molecular weight between 26,000 and 40,000 g/mol, grafted with alpha-tocopherol substituents, the average molar grafting ratio being 4.5-5.5 moles %, the weight/weight ratio between said grafted poly(glutamic acid) polymer and IFN-beta being between 24 and 125. The present invention also pertains to the preparation methods of such compositions and their application to obtain therapeutic compositions in dosage unit form delivering IFN-beta over an extended period of time.
摘要:
An aqueous emulsion comprising at least one (co)polymer is provided. The (co)polymer is derived from a monomer having formula (1):(R.sub.1 R.sub.2 C.dbd.CR.sub.3 --CO--L--).sub.q A(--NCOblock).sub.p(1)wherein R.sub.1, R.sub.2, and R.sub.3, which are the same or different, represent a hydrogen or a group selected from hydrocarbon chains comprising 1 to 12 carbon atoms, halogens, and electron-withdrawing functional groups; L, which is the same or different, represents a divalent hydrocarbon radical comprising 2 to 12 carbon atoms; A represents an organic backbone which has n free valencies, n is a number between 2 and 7, and is equal to p+q; NCOblock represents a protected isocyanate functional group; p is a number between 1 and 6; and q is a number between 1 and 6.
摘要:
Transparent receptor substrates, well suited for electrostatic reprography, e.g., for the production of overhead transparencies, exhibit excellent transparency, good slip, good adhesion of toner thereto and good electrical conductivity, comprise (i) a transparent composite polyester base(s) having (ii) a toner-receptive primer coating (P) on at least one of the face surfaces thereof, such composite polyester base comprising (a) a thick layer (A) of semicrystalline polyester and (b) a thin layer (B) of an identical or different polyester adhered to at least one of the face surfaces of said thick layer (A), and the at least one primer coating (P) comprising an acrylic polymer having a glass transition temperature ranging from 10.degree. C. to 50.degree. C., a free --COOH carboxylic functional group content less than 50 millimoles per 100 grams of said acrylic polymer and a thickness no greater than 0.3 .mu.m.
摘要:
Stable reactive aqueous dispersions of functional graft polyorganosiloxanes, well suited for formulation into curable silicone compositions useful in the production of release- and other coatings and paints, comprise the polymerizate of at least one ethylenically unsaturated monomer with a functional polyorganosiloxane which comprises identical or different recurring structural units of formula (I):R.sub.a Y.sub.b X.sub.c SiO.sub.(4-a-b-c)/2 (I)in which the radicals R, which may be identical or different, are each a C.sub.1 -C.sub.18 alkyl radical, a C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.6 -C.sub.12 aryl or aralkyl radical, or halogen-substituted such radical; the radicals X, which may be identical or different, are each a hydrogen atom or a reactive functional group bonded to a silicon atom via an Si-C or Si-O-C linkage; the radicals Y, which may be identical or different, are each an ethylenically unsaturated hydrocarbon radical optionally comprising one or more of the heteroelements O and/or N, and bonded to a silicon atom of the structural unit of formula (I) via an Si-C linkage and reactive with said at least one ethylenically unsaturated monomer; a, b and c are each equal to 0, 1, 2 or 3; and a+b+c=0, 1, 2 or 3; with the proviso that the number of SiO.sub.4/2 units is less than 30 mol % and the number of structural units of formula (I) in which the silicon atom is substituted by a functional group X and/or a radical Y is such that the polyorganosiloxane comprises (i) at least 5 milliequivalents, preferably from 10 to 500 milliequivalents, of X functional groups per 100 grams of polyorganosiloxane of formula (I) and (ii) at least 5 milliequivalents, preferably from 10 to 500 milliequivalents, of Y radicals per 100 grams of polyorganosiloxane of formula (I).
摘要:
The invention relates to a liquid pharmaceutical composition comprising a pegylated IFN-β (PEG-IFN-β), an excipient, a surfactant and a buffer wherein said excipient is a polyol, wherein said surfactant is a non-ionic surfactant and wherein said buffer is a sodium acetate buffer.
摘要:
An equalizer-combiner for a diversity receiver using at least two receive channels computes equalization coefficients for each channel allowing for a first channel error signal representative of a comparison between the demodulated signal and a channel estimate of the transmitted source signal delivered by a channel estimator fed with the demodulated signal in the channel during an acquisition phase and a second channel error signal representative of a comparison between the demodulated signal and the global estimate of the transmitted source signal during a normal operation phase. The equalizer-combiner computes the weighting coefficients allowing for a first global error signal representative of a comparison between the combined signal and the global estimate of the source signal during the acquisition phase a second global error signal representative of a comparison between local reference information known to the receiver and corresponding received reference information periodically extracted from the global estimate during the normal operation phase.
摘要:
Polymeric compositions well suited for conversion into electroconductive shaped articles, e.g., films, comprise at least one convertible polymer (Pm) and at least one amphiphilic organic compound (B) which comprises a charge transfer complex or a radical ion salt having the formula (I): D.sub.d A.sub.a Z.sub.z, in which D is an electron donor; A is an electron acceptor; Z is a doping agent which itself can be a non-amphiphilic electron donor or electron acceptor, with the proviso that at least one of D and A is amphiphilic and contains at least one saturated or unsaturated hydrocarbon substituent having at least 10 carbon atoms; d is a number equal to or greater than 0; a is a number equal to or greater than 0; and z is a number equal to or greater than 0, with the further proviso that at least one of the symbols d and a is a number greater than 0.
摘要:
A device for the reception of digital data broadcast at a high bit rate for reception by mobile receivers is disclosed. The device operates under adverse conditions of multiple propagation corresponding to the Rayleigh process and imperfect frequency tuning to minimize the inter-symbol interference in the frequency domain. The device receives a digital signal having digital elements distributed in the frequency-time space f-t and transmitted in the form of symbols each constituted by a multiplex of N orthogonal carrier frequencies modulated by a set of digital elements and broadcast simultaneously. The device includes a module for transposition by a local oscillator, baseband filtering and analog-digital conversion, a temporal windowing module for the selection of the useful samples and a mathematical transformation module, the temporal windowing module applying a Nyquist window type of temporal window with non-zero roll-off.
摘要:
The invention relates to growth hormone (GH) formulations having sustained-release properties, in particular human growth hormone (hGH) and methods for their preparation. The growth hormone formulations can be manufactured without denaturing of the protein and can conveniently be administrated to the person in need thereof by using a conventional syringe via a needle having a small diameter.