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    BIOLOGICAL DATA ANNOTATION AND VISUALIZATION
    11.
    发明申请
    BIOLOGICAL DATA ANNOTATION AND VISUALIZATION 有权
    生物数据的归纳和可视化

    公开(公告)号：US20160358326A1

    公开(公告)日：2016-12-08

    申请号：US14729982

    申请日：2015-06-03

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： Brion Daryl Sarachan ,  John Frederick Graf ,  Anup Sood ,  Vidya Pundalik Kamath

    IPC: G06T7/00 ,  G06F17/30 ,  G06F19/00

    CPC classification number: G06F17/30259 ,  G06F19/00 ,  G06F19/321

    Abstract: Dynamic linking of pathway maps and cell maps is disclosed in certain embodiments. In such embodiments, the pathway maps are linked to spatially-localized regional nucleic acid data (e.g., sequence data), as opposed to non-spatially selected nucleic acid data. The pathway map and cell map data may be linked so that interactions results in changes or updates to the linked map, such as the selection or highlighting of cells exhibiting pathway map characteristics specified by a user of updating of node values or states to correspond to that of a cell or cells selected by the user.

    Abstract translation: 在某些实施方案中公开了途径图和细胞图的动态连接。 在这样的实施方案中，与非空间选择的核酸数据相反，途径图连接到空间定位的区域核酸数据（例如序列数据）。 路径图和细胞图谱数据可以被链接，使得交互导致对链接的图的改变或更新，诸如显示由用户更新节点值或状态所指示的路径图特征的细胞的选择或突出显示，以对应于该 的用户选择的单元格或单元格。

    METHODS OF ANALYZING AN H&E STAINED BIOLOGICAL SAMPLE
    12.
    发明申请
    METHODS OF ANALYZING AN H&E STAINED BIOLOGICAL SAMPLE 有权
    分析H＆E污染生物样品的方法

    公开(公告)号：US20160069782A1

    公开(公告)日：2016-03-10

    申请号：US14772305

    申请日：2014-03-05

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： Anup Sood ,  Kevin Bernard Kenny ,  Arunkumar Natarajan ,  Lakshmi Sireesha Kaanumalle ,  Elizabeth Mary McDonough

    IPC: G01N1/30 ,  G01N33/58

    CPC classification number: G01N1/30 ,  G01N33/5005 ,  G01N33/582

    Abstract: Methods comprising probing multiple targets in an H&E stained biological sample are provided. The methods include the steps of providing a hematoxylin and eosin stained biological sample containing multiple targets, optionally detecting H&E staining of the sample, removing the hematoxylin and eosin signals, and detecting additional features or targets in the biological sample. The detecting step may include performing the steps of binding at least one probe to one or more targets to the sample, detecting a signal from the probe and contacting the sample with a bleaching agent. The process of binding, detecting and bleaching may be iteratively repeated.

    Abstract translation: 提供了包括在H＆E染色的生物样品中探测多个靶标的方法。 所述方法包括提供一个苏木精和曙红含有多个目标染色生物样本，任选检测所述样品的H＆E染色，除去苏木精和曙红信号，并且检测生物样品中另外的特征或对象的步骤。 检测步骤可以包括执行中的至少一个探针结合到一个或多个目标的样品中，检测来自探针的信号，并且与漂白剂接触所述样品的步骤。 结合，检测和漂白的过程可以迭代重复。

    PHOTOACTIVATED CHEMICAL BLEACHING OF DYES
    13.
    发明申请
    PHOTOACTIVATED CHEMICAL BLEACHING OF DYES 有权
    激光化学漂白剂

    公开(公告)号：US20130345089A1

    公开(公告)日：2013-12-26

    申请号：US14010889

    申请日：2013-08-27

    Applicant: General Electric Company

    Inventor： Arunkumar Natarajan ,  Anup Sood ,  Lakshmi Sireesha Kaanumalle ,  Kwok Pong Chan

    IPC: G01N33/58

    CPC classification number: G01N33/582 ,  G01N21/64 ,  G01N21/6428

    Abstract: Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with an electron transfer reagent and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The process of binding, observing and bleaching may be iteratively repeated.

    Abstract translation: 提供了包括使用光活化化学漂白来检测生物样品中的多个靶的方法。 所述方法包括以下步骤：提供含有多个靶标的生物样品，将至少一个探针结合到样品中存在的一个或多个靶，并观察来自探针的信号。 该方法还包括以下步骤：将包含结合的探针的样品与电子转移试剂接触并照射样品，从而引发光激活，其通过光活化的化学漂白使探针基本上灭活。 该方法还包括将至少一个探针结合到样品中存在的一个或多个靶，并观察来自探针的信号的步骤。 结合，观察和漂白的过程可以迭代地重复。

    PHOTOACTIVATED CHEMICAL BLEACHING OF DYES USING BORATES
    16.
    发明申请
    PHOTOACTIVATED CHEMICAL BLEACHING OF DYES USING BORATES 审中-公开
    使用硼酸的染料化学漂白染色

    公开(公告)号：US20160238592A1

    公开(公告)日：2016-08-18

    申请号：US14621715

    申请日：2015-02-13

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： Arunkumar Natarajan ,  Anup Sood ,  Lakshmi Sireesha Kaanumalle ,  Christina Lowes

    IPC: G01N33/536 ,  G01N1/30 ,  G01N33/58

    CPC classification number: G01N33/536 ,  G01N1/30 ,  G01N21/6428 ,  G01N33/582 ,  G01N2001/302

    Abstract: Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with a cationic or zwitterionic borate compound and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The process of binding, observing and bleaching may be iteratively repeated.

    Abstract translation: 提供了包括使用光活化化学漂白来检测生物样品中的多个靶的方法。 所述方法包括以下步骤：提供含有多个靶标的生物样品，将至少一个探针结合到样品中存在的一个或多个靶，并观察来自探针的信号。 该方法还包括使包含结合的探针的样品与阳离子或两性离子的硼酸盐化合物接触并照射样品的步骤，从而引发通过光活化的化学漂白基本上灭活探针的光反应。 该方法还包括将至少一个探针结合到样品中存在的一个或多个靶，并观察来自探针的信号的步骤。 结合，观察和漂白的过程可以迭代地重复。

    SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES
    17.
    发明申请
    SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES 审中-公开
    生物样品的序列分析

    公开(公告)号：US20140045251A1

    公开(公告)日：2014-02-13

    申请号：US14060650

    申请日：2013-10-23

    Applicant: General Electric Company

    Inventor： Anup Sood ,  Michael Christopher Montalto ,  Michael John Gerdes ,  Maximilian Lewis Seel ,  Robert John Filkins

    IPC: G01N33/53

    CPC classification number: G01N33/53 ,  C12Q1/68 ,  G01N33/542 ,  G01N33/582 ,  Y10T436/143333

    Abstract: Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.

    Abstract translation: 提供了用于检测生物样品中多个靶的方法。 所述方法包括使样品与第一探针接触; 将第一探针物理地绑定到第一靶; 观察来自第一探针的第一信号; 施用化学试剂来修饰第一信号; 使样品与第二探针接触; 将第二探针物理地绑定到第二靶上; 并观察来自第二探测器的第二信号。 本文公开的方法还提供绑定，观察，信号修改的多次迭代，用于导出关于单个样本中的多个目标的信息。 还提供了相关的套件和设备。

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