公开(公告)号：US20190080146A1

公开(公告)日：2019-03-14

申请号：US15703835

申请日：2017-09-13

Applicant: General Electric Company

Inventor： Alberto Santamaria-Pang ,  Qing Li ,  Yunxia Sui ,  Dmitry Vladimirovich Dylov ,  Christopher James Sevinsky ,  Michael E. Marino ,  Michael J. Gerdes ,  Daniel Eugene Meyer ,  Fiona Ginty ,  Anup Sood

IPC: G06K9/00 ,  G06T7/33

CPC classification number: G06K9/00147 ,  G06T7/0012 ,  G06T7/33 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/20104 ,  G06T2207/30024

Abstract: The subject matter of the present disclosure generally relates to techniques for image analysis. In certain embodiments, various morphological or intensity-based features as well as different thresholding approaches may be used to segment the subpopulation of interest and classify object in the images.

公开(公告)号：US09216010B2

公开(公告)日：2015-12-22

申请号：US13927683

申请日：2013-06-26

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Victor Petrovich Ostroverkhov ,  Dmitry Vladimirovich Dylov ,  Siavash Yazdanfar ,  Stephen B. Solomon

IPC: G01B11/14 ,  A61B10/02 ,  G01J3/00 ,  G01N21/31 ,  G01B11/00 ,  G01N21/65 ,  G01N21/64

CPC classification number: A61B10/02 ,  G01B11/002 ,  G01J3/00 ,  G01N21/31 ,  G01N21/65 ,  G01N2021/6417

Abstract: A spectroscopy system for auto-aligning a biopsy collecting device is presented. The spectroscopy system includes an illumination subsystem configured to emit an illumination light towards the biopsy collecting device, whereas the biopsy collecting device includes an activator unit and a needle unit and wherein the needle unit includes a cannula and a stylet having a biopsy specimen. Also, the spectroscopy system includes a fixation subsystem capable of holding the biopsy collecting device and configured to place the needle unit comprising the biopsy specimen across the illumination light. Further, the spectroscopy system includes a detection subsystem configured to receive a light comprising at least one of an attenuated illumination light and a re-emitted light from the needle unit. In addition, the detection subsystem is configured to send a control signal to align the needle unit at a predetermined position in the spectroscopy system based on the received light.

Abstract translation: 提出了一种用于自动对准活检收集装置的光谱系统。 光谱系统包括被配置为朝向活检收集装置发射照明光的照明子系统，而活检收集装置包括激活器单元和针单元，并且其中针单元包括插管和具有活检样本的探针。 此外，光谱系统包括固定子系统，其能够保持活检收集装置并且构造成将包括活检标本的针单元放置在照明光上。 此外，光谱系统包括被配置为接收包括衰减照明光和来自针单元的再发射光中的至少一种的光的检测子系统。 此外，检测子系统被配置为发送控制信号，以根据所接收的光将针单元对准在光谱系统中的预定位置。

公开(公告)号：US08934103B2

公开(公告)日：2015-01-13

申请号：US13663069

申请日：2012-10-29

Applicant: General Electric Company

Inventor： Evgenia Mikhailovna Kim ,  Siavash Yazdanfar ,  Dmitry Vladimirovich Dylov

IPC: G01B9/02 ,  G02B21/00 ,  G01B9/04 ,  G01N21/45 ,  G02B21/14 ,  G01B11/06

CPC classification number: G01B9/0209 ,  G01B9/04 ,  G01B11/0675 ,  G01N21/45 ,  G02B21/14

Abstract: Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

Abstract translation: 本文描述的系统和方法使用多个相差图像，其在由样品衍射的光和不被样品衍射的光之间具有各种相对相移，以产生定量相位图像。 所产生的定量相图可能具有足够的对比度，用于细胞体和细胞核的无标记自动分割。

公开(公告)号：US20150001420A1

公开(公告)日：2015-01-01

申请号：US13927543

申请日：2013-06-26

Applicant: General Electric Company

Inventor： Rajesh Veera Venkata Lakshmi Langoju ,  Abhijit Vishwas Patil ,  Sridhar Dasaratha ,  Vignesh Thirukazhukundram Subrahmaniam ,  Dmitry Vladimirovich Dylov ,  Siavash Yazdanfar ,  Stephen B. Solomon

IPC: G01N21/64

CPC classification number: G01N21/31 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/6849

Abstract: A method for classifying a tissue sample of a biopsy specimen into one of a plurality of classes is presented. The method includes receiving a light from at least one location of the tissue sample including a plurality of chromophores, wherein the received light comprises at least one of an attenuated illumination light and a re-emitted light. The method further includes processing a spectrum of the received light to determine a feature for each of the chromophores in the at least one location of the tissue sample. In addition, the method includes estimating a Z-score for each of the chromophores based on the determined feature. Also, the method includes classifying the tissue sample into one of the plurality of classes based on the estimated Z-score for each of the chromophores.

Abstract translation: 提出了将活检标本的组织样本分类为多个类别之一的方法。 该方法包括从包括多个发色团的组织样本的至少一个位置接收光，其中所接收的光包括衰减照明光和再发射光中的至少一个。 该方法还包括处理所接收的光的光谱以确定组织样本的至少一个位置中的每个发色团的特征。 此外，该方法包括基于所确定的特征来估计每个发色团的Z分数。 此外，该方法包括基于每个发色团的估计的Z分数将组织样本分类为多个类中的一个。