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公开(公告)号：US20170000438A1
公开(公告)日：2017-01-05
申请号：US14789585
申请日：2015-07-01
Applicant: GENERAL ELECTRIC COMPANY , RENSSELAER POLYTECHNIC INSTITUTE
Inventor： Robert John Filkins , Ahmad Nadeem Ishaque , Alok Mani Srivastava , Peter William Lorraine , Holly Ann Camanzo , Xiaolei Shi , Vasile Bogdan Neculaes , Sam Joseph Camardello , Gregory Boverman , Ge Wang , Wenxiang Cong
CPC classification number: A61B6/481 , A61B6/02 , A61B6/4258 , A61B6/485 , A61B8/0808 , A61B8/481 , A61K49/0015 , A61K49/0065
Abstract: The present approach generally relates to systems and methods for implementing energy modulated tomographic imaging of nanoparticles. In certain embodiments, a first energy is used to activate probe particles labeling an anatomy or tissue of interest. The probe particles, once activated, emit photons at a different rate and/or spectrum in response to an underlying physiological event, such as action potentials propagating in the labeled anatomy or tissue. The emitted photons may then be detected and used to map or image the occurrence of the physiological event.
Abstract translation: 本方法通常涉及用于实现纳米颗粒的能量调制层析成像的系统和方法。 在某些实施方案中，使用第一能量来激活标记感兴趣的解剖结构或组织的探针颗粒。 一旦被激活，探针颗粒响应于潜在的生理事件（例如在标记的解剖结构或组织中传播的动作电位）以不同的速率和/或光谱发射光子。 然后可以检测发射的光子并用于映射或成像生理事件的发生。
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公开(公告)号：US20160367632A1
公开(公告)日：2016-12-22
申请号：US15251990
申请日：2016-08-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
IPC: A61K38/18 , G01N33/49 , G01N33/487 , C12N13/00
CPC classification number: A61K38/1858 , A61K35/19 , C12N13/00 , G01N33/48707 , G01N33/49
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US20160355426A1
公开(公告)日：2016-12-08
申请号：US15244075
申请日：2016-08-23
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Vasile Bogdan Neculaes , Stephen Robert Vasconcellos , Brian Christopher Moore , Anthony John Murray , June Klimash , Kenneth Roger Conway , Tracy Lynn Paxon , Michael Brian Salerno , Casey L. Renko
CPC classification number: C02F11/12 , C02F1/302 , C02F1/42 , C02F3/342 , C02F11/02 , C02F11/122 , C02F11/123 , C02F11/127 , C02F11/14 , Y02W10/27
Abstract: Methods for treatment of sludge with microwave irradiation for improving its dewatering are provided. In one embodiment, the method includes exposing the sludge to microwave irradiation at an absorbed power density of between about 7 W/ml and about 13 W/ml. Turbidity, total solids content and overall dewaterability are improved when the microwave irradiation treatment is combined with another method for dewatering sludge, such as enzyme treatment, conditioning with a flocculating agent and mechanical dewatering.
Abstract translation: 提供了利用微波辐射处理污泥以改善其脱水的方法。 在一个实施方案中，该方法包括以约7W / ml至约13W / ml的吸收功率密度将污泥暴露于微波照射。 当微波照射处理与另一种用于脱水污泥的方法（如酶处理，用絮凝剂调理和机械脱水）相结合时，浊度，总固体含量和总脱水性得到改善。
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公开(公告)号：US12042526B2
公开(公告)日：2024-07-23
申请号：US17936162
申请日：2022-09-28
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Duh-Lan Lee , Allen Lawrence Garner
IPC: A61K38/18 , A61K35/19 , C12N13/00 , G01N33/487 , G01N33/49
CPC classification number: A61K38/1858 , A61K35/19 , C12N13/00 , G01N33/48707 , G01N33/49
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US20230013598A1
公开(公告)日：2023-01-19
申请号：US17936162
申请日：2022-09-28
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Duh-Lan Lee , Allen Lawrence Garner
IPC: A61K38/18 , A61K35/19 , G01N33/49 , C12N13/00 , G01N33/487
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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Patent Agency Ranking
公开(公告)号：US10744562B2
公开(公告)日：2020-08-18
申请号：US15005430
申请日：2016-01-25
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Mark Alan Frontera , Vasile Bogdan Neculaes , James William Sears , Peter Andras Zavodszky
Abstract: Adaptively forming a three-dimensional component may include providing a plurality of electron beam sources, and simultaneously controlling the plurality of electron beam sources to direct a plurality of electron beams onto a plurality of deposited layers of metallic powder to sequentially consolidate patterned portions of the plurality of deposited metallic powder layers to adaptively form the three-dimensional component.
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公开(公告)号：US20190264160A1
公开(公告)日：2019-08-29
申请号：US15905463
申请日：2018-02-26
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes
Abstract: Disclosed herein are multi-cuvette cartridges, flow cells, and electrical pulse systems for treatment of large volumes of biological samples with pulsed electric fields. The multi-cuvette cartridges systems may include mechanical motors for automatic positioning and alignment between the cuvettes and the electrodes of the electrical pulse systems. The flow cell systems may include fluidic systems, such as pumps, nozzles and valves, which may operate in coordination with the electrical systems for efficient exposition of biological samples. Embodiments having flow cell systems that allow “on-demand” production of activated sample are also disclosed.
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公开(公告)号：US10383915B2
公开(公告)日：2019-08-20
申请号：US15251990
申请日：2016-08-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US09244049B2
公开(公告)日：2016-01-26
申请号：US13888759
申请日：2013-05-07
Applicant: General Electric Company
Inventor： Yongjae Lee , Aghogho Atemu Obi , Seog Tae Kim , William Chester Platt , James William Bray , Yuri Alexeyevich Plotnikov , Jack Mathew Webster , Vasile Bogdan Neculaes
Abstract: A system for measuring nutritional parameters of food items is provided. The system includes a holding cavity. The system further includes a sensor assembly that includes a transmitter antenna and at least one receiver antenna. The transmitter antenna is configured to transmit signals to a food item in the holding cavity. The receiver antenna is configured to receive response signals from the food item. The system includes at least one switch coupled to each antenna. The switch, in a first state, is configured to set the sensor assembly to an electric potential equal to that of the holding cavity. In a second state, the switch is configured to couple the sensor assembly to a power source. The system also includes a processing unit to process the signals received to determine the nutritional parameters of the food item.
Abstract translation: 提供了一种用于测量食品营养参数的系统。 该系统包括一个保持腔。 该系统还包括传感器组件，其包括发射器天线和至少一个接收器天线。 发射机天线被配置为将信号发送到保持腔中的食物。 接收器天线被配置为从食品接收响应信号。 该系统包括耦合到每个天线的至少一个开关。 在第一状态下的开关被配置成将传感器组件设置成等于保持腔的电位。 在第二状态下，开关被配置成将传感器组件耦合到电源。 该系统还包括处理单元，用于处理所接收的信号以确定食品的营养参数。
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公开(公告)号：US09078862B2
公开(公告)日：2015-07-14
申请号：US13912050
申请日：2013-06-06
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Antonio Caiafa , Brian Duh-Lan Lee , Nicole Evelyn LaPlante , Andrew Soliz Torres , Allen Lawrence Garner
CPC classification number: A61K35/19 , A61K41/00 , A61N1/00 , C12N5/0644 , C12N13/00
Abstract: Embodiments of the disclosure relate to platelet activation and/or aggregation using electric pulses. In one embodiment, a platelet-containing sample is exposed to electric pulses. At least one of the electric pulses has a duration greater than 1 microsecond and a field strength below 50 kV/cm. In another embodiment, the electric pulses may be designed with particular field strengths and durations.
Abstract translation: 本公开的实施方案涉及使用电脉冲的血小板活化和/或聚集。 在一个实施方案中，将含血小板的样品暴露于电脉冲。 电脉冲中的至少一个具有大于1微秒的持续时间和低于50kV / cm的场强。 在另一个实施例中，电脉冲可以被设计为具有特定的场强和持续时间。
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