公开(公告)号：US12030903B2

公开(公告)日：2024-07-09

申请号：US17178115

申请日：2021-02-17

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Gregory F. Chin ,  Michael O. Clarke ,  Bindu Goyal ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel

IPC: C07F9/6561 ,  A61K45/06

CPC classification number: C07F9/6561 ,  A61K45/06

Abstract: The present disclosure describes 4′-fluoromethyl nucleosides for treating viral infections, including Dengue.

公开(公告)号：US20250002513A1

公开(公告)日：2025-01-02

申请号：US18673168

申请日：2024-05-23

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Gregory F. Chin ,  Michael O. Clarke ,  Bindu Goyal ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel

IPC: C07F9/6561 ,  A61K45/06

Abstract: The present disclosure describes 4′-fluoromethyl nucleosides for treating viral infections, including Dengue.

公开(公告)号：US20240279186A1

公开(公告)日：2024-08-22

申请号：US18428316

申请日：2024-01-31

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:






or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20240174704A1

公开(公告)日：2024-05-30

申请号：US18354362

申请日：2023-07-18

Applicant: GILEAD SCIENCES, INC.

Inventor： Gregory F. Chin ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Dustin S. Siegel ,  Hai Yang

IPC: C07F9/6561 ,  A61P31/14

CPC classification number: C07F9/6561 ,  A61P31/14

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US11919869B2

公开(公告)日：2024-03-05

申请号：US18050404

申请日：2022-10-27

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:




or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20230183189A1

公开(公告)日：2023-06-15

申请号：US18050404

申请日：2022-10-27

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:




or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20220356196A1

公开(公告)日：2022-11-10

申请号：US17176497

申请日：2021-02-16

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Gregory F. Chin ,  Byoung-kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  David Sperandio ,  Hai Yang ,  Lijun Zhang

IPC: C07F9/6561

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.