专利检索 ap:("Gary Mark Coppola" OR "Yuki Iwaki" OR "Rajeshri Ganesh Karki" OR "Toshio Kawanami" OR "Gary Michael Ksander" OR "Muneto Mogi" OR "Robert Sun") AND inv:"Toshio Kawanami" 第 2 页

11.

发明授权
Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors 有权
标题翻译：取代的氨基双苯基戊酸衍生物作为NEP抑制剂

公开(公告)号：US08673974B2

公开(公告)日：2014-03-18

申请号：US13294262

申请日：2011-11-11

申请人： Gary Mark Coppola , Rajeshri Ganesh Karki , Toshio Kawanami

发明人： Gary Mark Coppola , Rajeshri Ganesh Karki , Toshio Kawanami

IPC分类号： A01N37/10

CPC分类号： C07C235/74

摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, A1, X, X1, s and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of the compounds of the invention and a combination of pharmacologically active agents and a compound of the invention.

摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中R1，R2，R3，A1，X，X1，s和n如本文所定义。本发明还涉及制备本发明化合物的方法及其治疗用途。本发明还提供本发明化合物的药物组合物和药理活性剂与本发明化合物的组合。

12.

发明授权
Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors 有权

公开(公告)号：US08877786B2

公开(公告)日：2014-11-04

申请号：US14093956

申请日：2013-12-02

申请人： Yuki Iwaki , Toshio Kawanami , Gary Michael Ksander , Muneto Moji

发明人： Yuki Iwaki , Toshio Kawanami , Gary Michael Ksander , Muneto Moji

IPC分类号： A61K31/41 , A61K31/42 , C07D257/06 , C07D261/14 , C07D231/40 , A61K45/00

CPC分类号： A61K31/41 , A61K31/42 , A61K45/00 , C07D231/40 , C07D257/06 , C07D261/14

摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R6, A1, A2, X1, s and m are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

13.

发明授权
4-benzylamino-1-carboxylacyl-piperidine derivatives as CETP inhibitors 有权
标题翻译： 4-苄基氨基-1-羧基 - 哌啶衍生物作为CETP抑制剂

公开(公告)号：US08193349B2

公开(公告)日：2012-06-05

申请号：US12265369

申请日：2008-11-05

申请人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase

发明人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase

IPC分类号： C07D401/14 , C07D413/14

CPC分类号： C07D401/14 , C07D413/14

摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.

摘要翻译： 本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R5，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于治疗由CETP介导的或对CETP的抑制作用的疾病或疾病。

14.

发明申请
ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物

公开(公告)号：US20090286790A1

公开(公告)日：2009-11-19

申请号：US12374463

申请日：2007-07-18

申请人： Hidetomo Imase , Yuki Iwaki , Toshio Kawanami , Takahiro Miyake , Muneto Mogi , Osamu Ohmori , Hongbo Qin , Ichiro Umemura , Ken Yamada , Kayo Yasoshima

发明人： Hidetomo Imase , Yuki Iwaki , Toshio Kawanami , Takahiro Miyake , Muneto Mogi , Osamu Ohmori , Hongbo Qin , Ichiro Umemura , Ken Yamada , Kayo Yasoshima

IPC分类号： A61K31/5377 , C07D211/58 , A61K31/4468 , C07D239/42 , A61K31/506 , C07D413/04 , A61P9/04 , A61P9/10 , A61P9/00

CPC分类号： C07D211/58 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14

摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.

摘要翻译： 本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R5，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于治疗由CETP介导的或对CETP的抑制作用的疾病或疾病。

15.

发明授权
4-benzylamino-1-carboxylacyl-piperidine derivatives as CETP inhibitors 有权
标题翻译： 4-苄基氨基-1-羧基 - 哌啶衍生物作为CETP抑制剂

公开(公告)号：US08440682B2

公开(公告)日：2013-05-14

申请号：US13490579

申请日：2012-06-07

申请人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase

发明人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase

IPC分类号： A61K31/506 , A61P3/06 , A61P9/10 , A61P9/04 , A61P7/02 , A61P9/12 , A61P3/10 , A61P3/04 , A61P9/00 , C07D401/14

CPC分类号： C07D401/14 , C07D413/14

摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.

摘要翻译： 本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R5，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于治疗由CETP介导的或对CETP的抑制作用的疾病或疾病。

16.

发明授权
Method of inhibiting CETP activity with 4-benzylamino-1-carboxylacyl-piperidine derivatives 有权
标题翻译：用4-苄氨基-1-羧酰基 - 哌啶衍生物抑制CETP活性的方法

公开(公告)号：US08420641B2

公开(公告)日：2013-04-16

申请号：US13449347

申请日：2012-04-18

申请人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase

发明人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase

IPC分类号： A61K31/5377 , C07D401/14 , C07D413/14 , A61K31/506 , A61P9/00 , A61P3/04 , A61P3/00 , A61P9/10 , A61P3/10 , A61P9/12 , A61P3/06

CPC分类号： C07D401/14 , C07D413/14

摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.

摘要翻译： 本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R5，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于治疗由CETP介导的或对CETP的抑制作用的疾病或疾病。

17.

发明申请
ORGANIC COMPOUNDS 有权

公开(公告)号：US20090118287A1

公开(公告)日：2009-05-07

申请号：US12265369

申请日：2008-11-05

申请人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase

发明人： Muneto Mogi , Ken Yamada , Kayo Yasoshima , Toshio Kawanami , Ichiro Umemura , Yuki Iwaki , Hongbo Qin , Hidetomo Imase

IPC分类号： A61K31/506 , C07D413/14 , C07D401/14 , A61P9/00 , A61P3/00 , A61K31/5377

CPC分类号： C07D401/14 , C07D413/14

摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.

18.

发明授权
Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5A receptor modulators 有权
标题翻译：四氢吡啶并吡啶和四氢吡啶并嘧啶化合物及其作为C5A受体调节剂的用途

公开(公告)号：US09505755B2

公开(公告)日：2016-11-29

申请号：US14455848

申请日：2014-08-08

申请人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay

发明人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay

IPC分类号： C07D471/04 , C07D491/107 , C07D491/044 , C07D471/10 , C07D471/08

CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107

摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

19.

发明授权
Complement factor B inhibitors and uses there of 有权
标题翻译：补体因子B抑制剂及其用途

公开(公告)号：US09475806B2

公开(公告)日：2016-10-25

申请号：US14774430

申请日：2014-03-13

申请人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang

发明人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang

IPC分类号： C07D401/14 , A61K31/4353 , A61K31/437 , C07D471/04

CPC分类号： C07D471/04

摘要： The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.