公开(公告)号：US20190177390A1

公开(公告)日：2019-06-13

申请号：US16196936

申请日：2018-11-20

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Ganesh A. Kolumam ,  Xiaoting Wang ,  Jed Ross ,  Nicholas Van Bruggen ,  Wyne P. Lee

IPC: C07K14/54 ,  A61K38/20 ,  A61K47/38 ,  C07K16/28

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US20240383984A1

公开(公告)日：2024-11-21

申请号：US18675452

申请日：2024-05-28

Applicant: Genentech, Inc.

Inventor： Isidro Hotzel ,  Teemu T. Junttila ,  Ji Li ,  Justin Scheer ,  Danielle Dicara ,  Diego Ellerman ,  Christoph Spiess ,  Paul J. Carter

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  C07K16/30 ,  G01N33/574

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US12030947B2

公开(公告)日：2024-07-09

申请号：US17514824

申请日：2021-10-29

Applicant: Genentech, Inc.

Inventor： Isidro Hotzel ,  Teemu T. Junttila ,  Ji Li ,  Justin Scheer ,  Danielle Dicara ,  Diego Ellerman ,  Christoph Spiess ,  Paul J. Carter

IPC: A61K39/395 ,  A61K39/40 ,  A61K45/06 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00 ,  C07K16/00

CPC classification number: C07K16/283 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6851 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/30 ,  G01N33/57492 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/62 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N2333/70535

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US11136365B2

公开(公告)日：2021-10-05

申请号：US16196823

申请日：2018-11-20

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Ganesh A. Kolumam ,  Xiaoting Wang ,  Jed Ross ,  Nicholas Van Bruggen

IPC: C07K14/54 ,  C07K16/28 ,  A61K38/20 ,  A61K47/38 ,  A61K38/00

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US10689447B2

公开(公告)日：2020-06-23

申请号：US13958318

申请日：2013-08-02

Applicant: Genentech, Inc.

Inventor： J. Michael Elliott ,  Justin Scheer

IPC: C07K16/30 ,  C07K14/705 ,  C07K19/00 ,  C07K16/28 ,  C07K16/24 ,  C07K16/46

Abstract: Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

公开(公告)号：US10087227B2

公开(公告)日：2018-10-02

申请号：US15369236

申请日：2016-12-05

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Xiaoting Wang

IPC: C12N15/25 ,  C07K14/54

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US11912773B2

公开(公告)日：2024-02-27

申请号：US16872974

申请日：2020-05-12

Applicant: Genentech, Inc.

Inventor： J. Michael Elliott ,  Justin Scheer

IPC: C07K16/30 ,  C07K14/705 ,  C07K19/00 ,  C07K16/28 ,  C07K16/24 ,  C07K16/46

CPC classification number: C07K16/2863 ,  C07K16/244 ,  C07K16/247 ,  C07K16/468

Abstract: Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

公开(公告)号：US11725065B2

公开(公告)日：2023-08-15

申请号：US16820660

申请日：2020-03-16

Applicant: Genentech, Inc.

Inventor： Glen Giese ,  Amy Lim ,  Josefine Persson ,  Justin Scheer ,  Ambrose Williams

IPC: C07K16/46

CPC classification number: C07K16/468 ,  C07K2317/31 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/622

Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.

公开(公告)号：US11332507B2

公开(公告)日：2022-05-17

申请号：US16128008

申请日：2018-09-11

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Xiaoting Wang

IPC: A61K38/20 ,  C07K14/54 ,  C07K16/28 ,  A61K47/38 ,  A61K38/00

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US10941190B2

公开(公告)日：2021-03-09

申请号：US15344123

申请日：2016-11-04

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Whitney Shatz ,  Domingos Ng

IPC: C07K16/00 ,  C07K16/46 ,  C07K1/00 ,  C07K1/02 ,  C12P21/02 ,  C12P21/00 ,  C12N15/79 ,  C12N15/90

Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes located on a single molecule or located on different molecules.