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公开(公告)号:US06737248B2
公开(公告)日:2004-05-18
申请号:US08781986
申请日:1997-01-03
申请人: Charles A. Kunsch , Gil A. Choi , Steven C. Barash , Patrick J. Dillon , Michael R. Fannon , Craig A. Rosen
发明人: Charles A. Kunsch , Gil A. Choi , Steven C. Barash , Patrick J. Dillon , Michael R. Fannon , Craig A. Rosen
IPC分类号: C12P2102
CPC分类号: C12N15/1093 , A61K39/00 , C07K14/31 , C12N15/52
摘要: The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
摘要翻译: 本发明提供了金黄色葡萄球菌基因组的多核苷酸序列,由多核苷酸序列编码的多肽序列,相应的多核苷酸和多肽,载体和包含多核苷酸的宿主,以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息,以及便于其使用的基于计算机的系统和方法。
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公开(公告)号:US06593114B1
公开(公告)日:2003-07-15
申请号:US08956171
申请日:1997-10-20
申请人: Charles A. Kunsch , Gil H. Choi , Steven Barash , Patrick J. Dillon , Michael R. Fannon , Craig A. Rosen
发明人: Charles A. Kunsch , Gil H. Choi , Steven Barash , Patrick J. Dillon , Michael R. Fannon , Craig A. Rosen
IPC分类号: C12N1564
CPC分类号: C07K14/31 , A61K39/00 , C12N15/1093 , C12N15/52
摘要: The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
摘要翻译: 本发明提供了金黄色葡萄球菌基因组的多核苷酸序列,由多核苷酸序列编码的多肽序列,相应的多核苷酸和多肽,载体和包含多核苷酸的宿主,以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息,以及便于其使用的基于计算机的系统和方法。
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公开(公告)号:US06448043B1
公开(公告)日:2002-09-10
申请号:US09071035
申请日:1998-05-04
申请人: Gil H. Choi , Camella Bailey , Alex Hromockyj , Charles A. Kunsch
发明人: Gil H. Choi , Camella Bailey , Alex Hromockyj , Charles A. Kunsch
IPC分类号: C07H2104
CPC分类号: C07K14/24 , C07K14/315
摘要: The present invention relates to a novel gene from E. faecalis, EF040, and the encoded polypeptides. Also provided are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis EF040 polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus EF040 nucleic acids, encoded polypeptides and anti-EF040 antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.
摘要翻译: 本发明涉及来自粪肠球菌的新基因,EF040和编码的多肽。 还提供了载体,宿主细胞,抗体及其制备方法。 本发明进一步涉及用于鉴定粪肠球菌EF040多肽活性的激动剂和拮抗剂的筛选方法。 本发明还涉及在生物样品中检测肠球菌EF040核酸,编码多肽和抗EF040抗体的诊断方法。 本发明还涉及用于预防或减轻肠球菌感染的新型疫苗。
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14.
公开(公告)号:US07049081B2
公开(公告)日:2006-05-23
申请号:US10739043
申请日:2003-12-19
申请人: Charles A. Kunsch , Arvind Chopra , Craig A. Rosen
发明人: Charles A. Kunsch , Arvind Chopra , Craig A. Rosen
CPC分类号: C07K14/82 , C12N2799/026
摘要: The present invention relates to novel antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3). BTG-2 and BTG-3 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译: 本发明涉及新型抗增殖基因。 更具体地,提供编码人B细胞易位基因2和3(BTG-2和BTG-3)的分离的核酸分子。 还提供了BTG-2和BTG-3多肽,载体,宿主细胞以及用于制备它们的重组方法也是如此。
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公开(公告)号:US06258777B1
公开(公告)日:2001-07-10
申请号:US09221844
申请日:1998-12-29
申请人: Charles A. Kunsch , Arvind Chopra , Craig A. Rosen
发明人: Charles A. Kunsch , Arvind Chopra , Craig A. Rosen
IPC分类号: C07K1400
CPC分类号: C07K14/82 , C12N2799/026
摘要: The present invention relates to novel antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3). BTG-2 and BTG-3 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译: 本发明涉及新型抗增殖基因。 更具体地,提供编码人B细胞易位基因2和3(BTG-2和BTG-3)的分离的核酸分子。 还提供了BTG-2和BTG-3多肽,载体,宿主细胞以及用于制备它们的重组方法也是如此。
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公开(公告)号:US06913907B2
公开(公告)日:2005-07-05
申请号:US10206576
申请日:2002-07-29
申请人: Gil H. Choi , Camella Bailey , Alex Hromockyj , Charles A. Kunsch
发明人: Gil H. Choi , Camella Bailey , Alex Hromockyj , Charles A. Kunsch
IPC分类号: B82B1/00 , A61K39/09 , A61P31/04 , C07K14/24 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12P21/02 , C12P21/04 , C12Q1/68 , G01N33/50 , G01N33/566 , C07H21/04 , C12N15/00 , C12P21/06
CPC分类号: C07K14/24 , C07K14/315
摘要: The present invention relates to novel genes from E. faecalis and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.
摘要翻译: 本发明涉及来自粪肠球菌的新基因及其编码的多肽。 还提供载体,宿主细胞,抗体及其制备方法。 本发明还涉及用于鉴定粪肠球菌多肽活性的激动剂和拮抗剂的筛选方法。 本发明还涉及在生物样品中检测肠球菌核酸,多肽和抗体的诊断方法。 本发明还涉及用于预防或减轻肠球菌感染的新型疫苗。
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公开(公告)号:US06689360B2
公开(公告)日:2004-02-10
申请号:US09843846
申请日:2001-04-30
申请人: Charles A. Kunsch , Arvind Chopra , Craig A. Rosen
发明人: Charles A. Kunsch , Arvind Chopra , Craig A. Rosen
IPC分类号: A61K39395
CPC分类号: C07K14/82 , C12N2799/026
摘要: The present invention relates to antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3). BTG-2 and BTG-3 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies to BTG-2 and BGT-3.
摘要翻译: 本发明涉及抗增殖基因。 更具体地,提供编码人B细胞易位基因2和3(BTG-2和BTG-3)的分离的核酸分子。 还提供了BTG-2和BTG-3多肽,载体,宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及BTG-2和BGT-3的抗体。
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公开(公告)号:US6013469A
公开(公告)日:2000-01-11
申请号:US718738
申请日:1996-09-18
申请人: Charles A. Kunsch , Arvind Chopra , Craig A. Rosen
发明人: Charles A. Kunsch , Arvind Chopra , Craig A. Rosen
CPC分类号: C07K14/82 , C12N2799/026
摘要: The present invention relates to novel antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3). BTG-2 and BTG-3 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译: 本发明涉及新型抗增殖基因。 更具体地,提供编码人B细胞易位基因2和3(BTG-2和BTG-3)的分离的核酸分子。 还提供了BTG-2和BTG-3多肽,载体,宿主细胞以及用于制备它们的重组方法也是如此。
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公开(公告)号:US5721113A
公开(公告)日:1998-02-24
申请号:US368281
申请日:1995-01-03
CPC分类号: C07K14/4702
摘要: Isolated nucleic acids encoding human lymphoid-specific transcription factors NERF-1 and NERF-2, proteins obtainable from the nucleic acids, recombinant host cells transformed with the nucleic acids and use of the proteins and nucleic acid sequences are dislcosed.
摘要翻译: 编码人淋巴特异性转录因子NERF-1和NERF-2的分离的核酸,可从核酸获得的蛋白质,用核酸转化的重组宿主细胞以及蛋白质和核酸序列的使用被消除。
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