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公开(公告)号：US06737248B2
公开(公告)日：2004-05-18
申请号：US08781986
申请日：1997-01-03
申请人： Charles A. Kunsch , Gil A. Choi , Steven C. Barash , Patrick J. Dillon , Michael R. Fannon , Craig A. Rosen
发明人： Charles A. Kunsch , Gil A. Choi , Steven C. Barash , Patrick J. Dillon , Michael R. Fannon , Craig A. Rosen
IPC分类号： C12P2102
CPC分类号： C12N15/1093 , A61K39/00 , C07K14/31 , C12N15/52
摘要： The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
摘要翻译： 本发明提供了金黄色葡萄球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。
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公开(公告)号：US06573082B1
公开(公告)日：2003-06-03
申请号：US09536784
申请日：2000-03-28
申请人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
发明人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
IPC分类号： C12N120
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
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公开(公告)号：US20100196410A1
公开(公告)日：2010-08-05
申请号：US12758672
申请日：2010-04-12
申请人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
发明人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
IPC分类号： A61K39/09 , C07H21/04 , C07K14/315 , C07K16/12 , A61P31/04 , C12N15/63 , C12N15/00 , C12N1/00 , C12P21/00 , C12Q1/68
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
摘要翻译： 本发明涉及用于预防或减轻肺炎链球菌感染的新型疫苗。 本发明还涉及编码肺炎链球菌抗原多肽的分离的核酸分子。 还提供了抗原多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及在生物样品中检测链球菌核酸，多肽和抗体的诊断方法。
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公开(公告)号：US06929930B2
公开(公告)日：2005-08-16
申请号：US09765272
申请日：2001-01-22
申请人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
发明人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
IPC分类号： G01N33/53 , A01K67/027 , A61K38/00 , A61K39/00 , A61K39/09 , A61K48/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N5/18 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , G01N33/50 , G01N33/569 , G06F17/30 , C07H21/04 , C12N15/00 , C12P21/06
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
摘要翻译： 本发明涉及用于预防或减轻肺炎链球菌感染的新型疫苗。 本发明还涉及编码肺炎链球菌抗原多肽的分离的核酸分子。 还提供了抗原多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及在生物样品中检测链球菌核酸，多肽和抗体的诊断方法。
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公开(公告)号：US07141418B2
公开(公告)日：2006-11-28
申请号：US10158844
申请日：2002-06-03
申请人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
发明人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
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6.发明授权Streptococcus pneumoniae SP036 polynucleotides, polypeptides, antigens and vaccines 失效肺炎链球菌SP036多核苷酸，多肽，抗原和疫苗公开(公告)号：US07056510B1
公开(公告)日：2006-06-06
申请号：US08961083
申请日：1997-10-30
申请人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
发明人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
IPC分类号： A61K39/40 , A61K39/00 , A61K39/38 , A61K39/385 , A61K39/02
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneunoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
摘要翻译： 本发明涉及用于预防或减轻由球形球菌引起的感染的新型疫苗。 本发明还涉及编码肺炎链球菌抗原多肽的分离的核酸分子。 还提供了抗原多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及在生物样品中检测链球菌核酸，多肽和抗体的诊断方法。
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公开(公告)号：US08168205B2
公开(公告)日：2012-05-01
申请号：US12635794
申请日：2009-12-11
申请人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
发明人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
摘要翻译： 本发明提供了肺炎链球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。
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公开(公告)号：US20100221287A1
公开(公告)日：2010-09-02
申请号：US12635794
申请日：2009-12-11
申请人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
发明人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
IPC分类号： A61K39/02 , C07H21/00 , C12N15/74 , C12N5/10 , C07K2/00 , A61K38/02 , C07K16/00 , C12P21/00 , A61P37/04 , A61P31/04
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
摘要翻译： 本发明提供了肺炎链球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。
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公开(公告)号：US6159469A
公开(公告)日：2000-12-12
申请号：US961083
申请日：1997-10-30
申请人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
发明人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
IPC分类号： G01N33/53 , A01K67/027 , A61K38/00 , A61K39/00 , A61K39/09 , A61K48/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N5/18 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , G01N33/50 , G01N33/569 , G06F17/30 , A61K39/40 , A61K39/02 , A61K39/385
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
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公开(公告)号：US06887663B1
公开(公告)日：2005-05-03
申请号：US09765271
申请日：2001-01-22
申请人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillion , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
发明人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillion , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
摘要翻译： 本发明涉及用于预防或减轻肺炎链球菌感染的新型疫苗。 本发明还涉及编码肺炎链球菌抗原多肽的分离的核酸分子。 还提供了抗原多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及在生物样品中检测链球菌核酸，多肽和抗体的诊断方法。
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