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公开(公告)号：US08652582B2
公开(公告)日：2014-02-18
申请号：US12937458
申请日：2009-05-26
申请人： Catherine A. Bothof , Yi He , Jerald K. Rasmussen , Kannan Seshadri , Clinton P. Waller, Jr. , Douglas E. Weiss
发明人： Catherine A. Bothof , Yi He , Jerald K. Rasmussen , Kannan Seshadri , Clinton P. Waller, Jr. , Douglas E. Weiss
IPC分类号： C08F2/46
CPC分类号： C07C279/12 , B01D39/1676 , B01J20/285 , C07C277/08 , C07C279/14 , C07C281/16 , C07K1/34 , C08F259/08 , C08F283/04 , C08G69/48 , C08J7/18 , C08J9/283 , C08J9/42 , C08J2327/16 , C08J2377/00 , C12N7/00 , Y02C10/08 , Y10T428/31855
摘要： Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. The ligand functionalized substrate may be described as the grafted reaction product of a substrate and a ligand monomer of Formula I:
摘要翻译： 配体功能化底物，制备配体官能化底物的方法，以及使用官能化底物的方法。 配体官能化底物可以描述为底物和式I的配体单体的接枝反应产物：
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公开(公告)号：US08377672B2
公开(公告)日：2013-02-19
申请号：US12986485
申请日：2011-01-07
申请人： Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , Erin A. Satterwhite , Robert T. Fitzsimons , James I. Hembre , Mahfuza B. Ali
发明人： Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , Erin A. Satterwhite , Robert T. Fitzsimons , James I. Hembre , Mahfuza B. Ali
CPC分类号： C08F220/56 , B01D15/00 , C08F20/00 , C08F26/02 , C08F220/60 , G01N33/54393 , Y10T428/12264 , Y10T428/249991
摘要： Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
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公开(公告)号：US08329034B2
公开(公告)日：2012-12-11
申请号：US12819261
申请日：2010-06-21
CPC分类号： B01D67/0093 , B01D39/1623 , B01D39/1692 , B01D63/00 , B01D63/10 , B01D63/14 , B01D67/009 , B01D69/10 , B01D69/105 , B01D2239/0421 , B01D2239/0464 , B01D2239/065 , B01D2239/069 , B01D2239/10 , B01D2239/1216 , B01D2239/1225 , B01D2239/1266 , B01D2239/1291 , B01D2323/385 , D04H1/42 , D04H1/4334 , D04H1/4382 , D04H1/56 , D06M14/26 , D06M14/28 , Y10T442/2008
摘要： A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising anionic monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify or separate target materials, such as monoclonal antibodies (MAb), from a fluid mixture.
摘要翻译： 公开了接枝非织造基材，其平均纤维尺寸为0.7至15微米，空隙体积为50至95％，以及包含接枝到非织造基材表面的阴离子单体单元的聚合物。 该制品可以用作过滤元件以从流体混合物中纯化或分离靶物质，例如单克隆抗体（MAb）。
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公开(公告)号：US20110201078A1
公开(公告)日：2011-08-18
申请号：US12986485
申请日：2011-01-07
申请人： Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , Erin A. Satterwhite , Robert T. Fitzsimons , James I. Hembre , Mahfuza B. Ali
发明人： Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , Erin A. Satterwhite , Robert T. Fitzsimons , James I. Hembre , Mahfuza B. Ali
IPC分类号： C12N9/00 , C08F220/56 , B32B3/26 , B01D15/38 , B01D21/01 , B01D15/08 , C12N7/02 , C07K1/32 , C12N1/20 , C12N1/02 , C12N5/00 , C07H1/06 , C07K1/14
CPC分类号： C08F220/56 , B01D15/00 , C08F20/00 , C08F26/02 , C08F220/60 , G01N33/54393 , Y10T428/12264 , Y10T428/249991
摘要： Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
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公开(公告)号：US20110033633A1
公开(公告)日：2011-02-10
申请号：US12937458
申请日：2009-05-26
申请人： Catherine A. Bothof , Yi He , Jerald K. Rasmussen , Kannan Seshadri , Clinton P. Waller, JR. , Douglas E. Weiss
发明人： Catherine A. Bothof , Yi He , Jerald K. Rasmussen , Kannan Seshadri , Clinton P. Waller, JR. , Douglas E. Weiss
IPC分类号： C08F2/54 , C07C233/09 , C07C229/26 , C07C69/54 , C08F2/48
CPC分类号： C07C279/12 , B01D39/1676 , B01J20/285 , C07C277/08 , C07C279/14 , C07C281/16 , C07K1/34 , C08F259/08 , C08F283/04 , C08G69/48 , C08J7/18 , C08J9/283 , C08J9/42 , C08J2327/16 , C08J2377/00 , C12N7/00 , Y02C10/08 , Y10T428/31855
摘要： Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
摘要翻译： 配体功能化底物，制备配体官能化底物的方法，以及使用官能化底物的方法。
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公开(公告)号：US08592493B2
公开(公告)日：2013-11-26
申请号：US13000435
申请日：2009-05-11
申请人： Simon K. Shannon , Catherine A. Bothof , Babu N. Gaddam , Jerald K. Rasmussen , Richard B. Ross
发明人： Simon K. Shannon , Catherine A. Bothof , Babu N. Gaddam , Jerald K. Rasmussen , Richard B. Ross
CPC分类号： C07K17/08 , B01D15/08 , B01D15/3804 , B01D15/3809 , B01J20/264 , B01J20/286 , B01J20/287 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3242 , B01J20/3255 , B01J20/3276 , B01J20/3278 , B01J20/328 , B01J39/17 , B01J39/18 , B01J39/20 , B01J41/12 , B01J41/14 , B01J2220/52 , B01J2220/54 , B01J2220/58 , B01J2220/62 , C07K1/22 , C08F271/02
摘要： Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample.
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公开(公告)号：US20110100916A1
公开(公告)日：2011-05-05
申请号：US13000435
申请日：2009-05-11
申请人： Simon K. Shannon , Catherine A. Bothof , Babu N. Gaddam , Jerald K. Rasmussen , Richard B. Ross
发明人： Simon K. Shannon , Catherine A. Bothof , Babu N. Gaddam , Jerald K. Rasmussen , Richard B. Ross
IPC分类号： B01J39/18 , C08F8/14 , C08F220/56 , C08F8/32
CPC分类号： C07K17/08 , B01D15/08 , B01D15/3804 , B01D15/3809 , B01J20/264 , B01J20/286 , B01J20/287 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3242 , B01J20/3255 , B01J20/3276 , B01J20/3278 , B01J20/328 , B01J39/17 , B01J39/18 , B01J39/20 , B01J41/12 , B01J41/14 , B01J2220/52 , B01J2220/54 , B01J2220/58 , B01J2220/62 , C07K1/22 , C08F271/02
摘要： Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample.
摘要翻译： 描述了含有从固体支持物延伸的接枝链的固体支持物的制品，制造这些制品的方法以及制品的各种用途。 更具体地，接枝链具有可与目标化合物反应或与其相互作用的官能团。 或者，接枝链上的官能团可以与改性剂反应，以提供可与目标化合物反应或与目标化合物相互作用的另一个基团。 接枝的链通过开环的吖内酯基团连接到固体支持物上。 该制品可用于纯化目标化合物或将目标化合物与样品中的其它分子分离。
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18.发明授权Materials, methods, and kits for reducing nonspecific binding of molecules to a surface 失效用于减少分子与表面的非特异性结合的材料，方法和试剂盒公开(公告)号：US07727710B2
公开(公告)日：2010-06-01
申请号：US10810738
申请日：2004-03-26
IPC分类号： C12Q3/00 , G01N33/53 , G01N33/543 , G01N33/551 , C09D11/00
CPC分类号： G01N33/54393 , C12Q1/6832 , Y10S435/962
摘要： The present invention provides materials, methods, and kits for reducing nonspecific binding of molecules to a surface, particularly in a solid phase material, and more specifically a solid phase material that includes a hydrophobic portion, by contacting the solid phase material with a fluorinated nonionic surfactant comprising two or more fluorinated hydrophobic segments and one or more hydrophilic segments.
摘要翻译： 本发明提供用于减少分子与表面特别是固相材料的非特异性结合的材料，方法和试剂盒，更具体地说，通过使固相材料与氟化非离子表面活性剂接触，包括疏水部分的固相材料 包含两个或多个氟化疏水链段和一个或多个亲水链段的表面活性剂。
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