公开(公告)号：US20080318835A1

公开(公告)日：2008-12-25

申请号：US12040449

申请日：2008-02-29

申请人： Zdenka L. Jonak ,  Stephen H. Trulli ,  James A. Fornwald ,  Jonathan A. Terrett ,  Gregg A. Hastings

发明人： Zdenka L. Jonak ,  Stephen H. Trulli ,  James A. Fornwald ,  Jonathan A. Terrett ,  Gregg A. Hastings

IPC分类号： A61K38/02 ,  C07H21/04 ,  C07H21/02 ,  C12N5/10 ,  C12P21/02 ,  C12N15/87 ,  C12Q1/68 ,  G01N33/567 ,  C07K14/47 ,  C07K16/18 ,  A61K31/711 ,  A61K48/00

CPC分类号： C12N9/6489 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4702 ,  C12Q1/37 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/564 ,  G01N33/57496 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2500/00 ,  G01N2800/102 ,  G01N2800/164 ,  G01N2800/24 ,  G01N2800/2821 ,  G01N2800/323

摘要： ITGL-TSP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ITGL-TSP polypeptides and polynucleotides in the design of protocols for the treatment of, angiogenic diseases (cancer, cancer metastasis, chronic inflammatory disorders, rheumatoid arthritis, atherosclerosis, macular degeneration, diabetic retmopathy), restenosis, Alzheimer's, disease and tissue remodeling, among others, and diagnostic assays for such conditions.

摘要翻译： 公开了ITGL-TSP多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗血管生成疾病（癌症，癌症转移，慢性炎症性疾病，类风湿性关节炎，动脉粥样硬化，黄斑变性，糖尿病性视网膜病变），再狭窄，阿尔茨海默氏症等的方案中使用ITGL-TSP多肽和多核苷酸的方法。 疾病和组织重塑等，以及这些病症的诊断测定。

公开(公告)号：US5501969A

公开(公告)日：1996-03-26

申请号：US208007

申请日：1994-03-08

申请人： Gregg A. Hastings ,  Mark D. Adams ,  Claire M. Fraser ,  Norman H. Lee ,  Ewen F. Kirkness ,  Judith A. Blake ,  Lisa M. Fitzgerald ,  Fred H. Drake ,  Maxine Gowan

发明人： Gregg A. Hastings ,  Mark D. Adams ,  Claire M. Fraser ,  Norman H. Lee ,  Ewen F. Kirkness ,  Judith A. Blake ,  Lisa M. Fitzgerald ,  Fred H. Drake ,  Maxine Gowan

IPC分类号： G01N33/53 ,  A61K31/70 ,  A61K38/00 ,  A61K38/46 ,  A61K38/48 ,  A61K39/395 ,  A61K48/00 ,  A61P19/08 ,  A61P19/10 ,  A61P35/00 ,  A61P43/00 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C07K14/47 ,  C07K16/40 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/48 ,  C12N9/50 ,  C12N9/64 ,  C12N15/09 ,  C12N15/11 ,  C12N15/57 ,  C12N15/66 ,  C12P19/34 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/37 ,  G01N33/535 ,  C12N15/63

CPC分类号： C12N9/6472 ,  C07K16/40 ,  A61K38/00

摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

公开(公告)号：US06680375B2

公开(公告)日：2004-01-20

申请号：US10114464

申请日：2002-04-03

申请人： Gregg A. Hastings ,  Mark D. Adams ,  Claire M. Fraser ,  Norman H. Lee ,  Ewen F. Kirkness ,  Judith A. Blake ,  Lisa M. Fitzgerald ,  Fred H. Drake ,  Maxine Gowan

发明人： Gregg A. Hastings ,  Mark D. Adams ,  Claire M. Fraser ,  Norman H. Lee ,  Ewen F. Kirkness ,  Judith A. Blake ,  Lisa M. Fitzgerald ,  Fred H. Drake ,  Maxine Gowan

IPC分类号： C07K1600

CPC分类号： C12N9/6472 ,  A61K38/00 ,  C07K16/40

摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

摘要翻译： 公开了一种人破骨细胞来源的组织蛋白酶（组织蛋白酶O）多肽和编码这种组织蛋白酶O多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 本发明还公开了这种多肽的抗体，拮抗剂和抑制剂，其可用于预防这种多肽的作用，因此可用于治疗性治疗骨疾病如骨质疏松症和癌症如肿瘤转移。

公开(公告)号：US06541452B1

公开(公告)日：2003-04-01

申请号：US09722292

申请日：2000-11-28

申请人： Gregg A. Hastings ,  Timothy A. Coleman ,  Daniel A. Lawrence ,  Patrick J. Dillon

发明人： Gregg A. Hastings ,  Timothy A. Coleman ,  Daniel A. Lawrence ,  Patrick J. Dillon

IPC分类号： A61K3857

CPC分类号： C07K14/8132 ,  A61K38/00 ,  C07K14/8121

摘要： The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.

摘要翻译： 本发明涉及一种新的BAIT蛋白，其是主要在脑组织中表达的丝氨酸蛋白酶超家族的成员。 特别地，提供编码人BAIT蛋白的分离的核酸分子。 还提供了BAIT多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及鉴定BAIT活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测神经系统相关疾病的诊断方法和用于治疗神经系统相关疾病的治疗方法。

公开(公告)号：US06475766B1

公开(公告)日：2002-11-05

申请号：US08553125

申请日：1995-11-07

申请人： Gregg A. Hastings ,  Mark D. Adams ,  Claire M. Fraser ,  Norman H. Lee ,  Ewen F. Kirkness ,  Judith A. Blake ,  Lisa M. Fitzgerald ,  Fred H. Drake ,  Maxine Gowan

发明人： Gregg A. Hastings ,  Mark D. Adams ,  Claire M. Fraser ,  Norman H. Lee ,  Ewen F. Kirkness ,  Judith A. Blake ,  Lisa M. Fitzgerald ,  Fred H. Drake ,  Maxine Gowan

IPC分类号： C12N964

CPC分类号： C12N9/6472 ,  A61K38/00 ,  C07K16/40

摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

公开(公告)号：US5861298A

公开(公告)日：1999-01-19

申请号：US852807

申请日：1997-05-07

申请人： Mark D. Adams ,  Judith A. Blake ,  Christine M. Debouck ,  Fred H. Drake ,  Lisa M. Fitzgerald ,  Claire M. Fraser ,  Maxine Gowen ,  Gregg A. Hastings ,  Ewen F. Kirkness ,  Norman H. Lee ,  Julie Rood

发明人： Mark D. Adams ,  Judith A. Blake ,  Christine M. Debouck ,  Fred H. Drake ,  Lisa M. Fitzgerald ,  Claire M. Fraser ,  Maxine Gowen ,  Gregg A. Hastings ,  Ewen F. Kirkness ,  Norman H. Lee ,  Julie Rood

IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N9/64 ,  C12N15/11 ,  C12N15/57 ,  C12N15/63 ,  C12P21/02

CPC分类号： C12N9/6472 ,  A61K38/00 ,  A61K48/00

摘要： The invention relates to cathepsin K polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及组织蛋白酶K多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

公开(公告)号：US20080312146A1

公开(公告)日：2008-12-18

申请号：US11751261

申请日：2007-05-21

申请人： Luisa Iruela-Arispe ,  Gregg A. Hastings ,  Steven M. Ruben ,  Zdenka L. Jonak ,  Stephen H. Trulli ,  James A. Fornwald ,  Jonathan A. Terrett

发明人： Luisa Iruela-Arispe ,  Gregg A. Hastings ,  Steven M. Ruben ,  Zdenka L. Jonak ,  Stephen H. Trulli ,  James A. Fornwald ,  Jonathan A. Terrett

IPC分类号： A61K38/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  A61P9/00 ,  C12N15/87 ,  C12P21/04 ,  C07K14/00

CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K48/00 ,  C07K14/78 ,  C07K2319/00 ,  C12N9/6489 ,  C12N2799/026

摘要： The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 or METH2. Also provided are methods for inhibiting angiogenesis using METH1 or METH2.

摘要翻译： 本发明涉及与血小板反应蛋白相关的新型抗血管生成蛋白。 更具体地，提供编码人METH1和METH2的分离的核酸分子。 还提供了METH1和METH2多肽，以及载体，宿主细胞和用于制备它们的重组方法。 还提供了用于预测癌症的诊断方法和用于治疗需要增加量的METH1或METH2的个体的治疗方法。 还提供了使用METH1或METH2抑制血管生成的方法。

公开(公告)号：US06475487B2

公开(公告)日：2002-11-05

申请号：US09953956

申请日：2001-09-18

申请人： Gregg A. Hastings ,  Mark D. Adams ,  Claire M. Fraser ,  Norman H. Lee ,  Ewen F. Kirkness ,  Judith A. Blake ,  Lisa M. Fitzgerald ,  Fred H Drake ,  Maxine Gowan

发明人： Gregg A. Hastings ,  Mark D. Adams ,  Claire M. Fraser ,  Norman H. Lee ,  Ewen F. Kirkness ,  Judith A. Blake ,  Lisa M. Fitzgerald ,  Fred H Drake ,  Maxine Gowan

IPC分类号： A61K39395

CPC分类号： C12N9/6472 ,  A61K38/00 ,  C07K16/40

摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases. A patient is treated by administering an antibody produced against a polypeptide consisting of SEQ ID NO: 2.

摘要翻译： 公开了一种人破骨细胞来源的组织蛋白酶（组织蛋白酶O）多肽和编码这种组织蛋白酶O多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 本发明还公开了这种多肽的抗体，拮抗剂和抑制剂，其可用于预防这种多肽的作用，因此可用于治疗性治疗骨疾病如骨质疏松症和癌症如肿瘤转移。 通过施用针对由SEQ ID NO：2组成的多肽产生的抗体来治疗患者。

公开(公告)号：US06191260B1

公开(公告)日：2001-02-20

申请号：US09348817

申请日：1999-07-08

申请人： Gregg A. Hastings ,  Timothy A. Coleman ,  Daniel A. Lawrence ,  Patrick J. Dillon

发明人： Gregg A. Hastings ,  Timothy A. Coleman ,  Daniel A. Lawrence ,  Patrick J. Dillon

IPC分类号： C07K1481

CPC分类号： C07K14/8132 ,  A61K38/00 ,  C07K14/8121

摘要： The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.

摘要翻译： 本发明涉及一种新的BAIT蛋白，其是主要在脑组织中表达的丝氨酸蛋白酶超家族的成员。 特别地，提供编码人BAIT蛋白的分离的核酸分子。 还提供了BAIT多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及鉴定BAIT活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测神经系统相关疾病的诊断方法和用于治疗神经系统相关疾病的治疗方法。

公开(公告)号：US6008020A

公开(公告)日：1999-12-28

申请号：US948997

申请日：1997-10-10

申请人： Gregg A. Hastings ,  Timothy A. Coleman ,  Daniel A. Lawrence ,  Patrick J. Dillon

发明人： Gregg A. Hastings ,  Timothy A. Coleman ,  Daniel A. Lawrence ,  Patrick J. Dillon

IPC分类号： A61K38/00 ,  C07K14/81 ,  C12P21/06 ,  C07H21/04 ,  C12N5/00 ,  C12N15/00

CPC分类号： C07K14/8132 ,  C07K14/8121 ,  A61K38/00

摘要： The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.