公开(公告)号：US20140121384A1

公开(公告)日：2014-05-01

申请号：US14127425

申请日：2012-05-24

Applicant: Hetero Research Foundation

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reedy ,  Dasari Muralidhara Reddy ,  Bandi Vamsi Krishna

IPC: C07D235/16

CPC classification number: C07D235/16 ,  C07D513/04

Abstract: The present invention provides a process for the preparation of 1H-benzimidazol-1-methyl-5-N,N-di(2-hydroxyethyl)-2-butanoic acid ethyl ester. The present invention also provides a process for the preparation of bendamustine hydrochloride. The present invention further provides a process for the purification of bendamustine hydrochloride.

Abstract translation: 本发明提供了制备1H-苯并咪唑-1-甲基-5-N，N-二（2-羟乙基）-2-丁酸乙酯的方法。 本发明还提供了盐酸苯达莫司汀的制备方法。 本发明还提供了盐酸苯达莫司汀的纯化方法。

公开(公告)号：US20140100252A1

公开(公告)日：2014-04-10

申请号：US14122158

申请日：2012-05-21

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Bandi Vamsi Krishna

IPC: C07D277/28 ,  A61K45/06 ,  A61K31/427 ,  A61K47/32

CPC classification number: C07D277/28 ,  A61K31/427 ,  A61K45/06 ,  A61K47/32

Abstract: The present invention relates to amorphous ritonavir co-precipitated on copovidone, process for its preparation and pharmaceutical compositions comprising it.

Abstract translation: 本发明涉及在共聚维酮上共沉淀的无定形利托那韦，其制备方法和包含它的药物组合物。

公开(公告)号：US10934251B2

公开(公告)日：2021-03-02

申请号：US16797498

申请日：2020-02-21

Applicant: Hetero Research Foundation

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Bandi Vamsi Krishna ,  Jambula Mukunda Reddy

IPC: C07C231/02 ,  C07D211/58 ,  C07C231/12 ,  C07C67/293 ,  C07C69/157 ,  C07C51/367 ,  C07C62/32

Abstract: The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels of impurities.

公开(公告)号：US20180148412A1

公开(公告)日：2018-05-31

申请号：US15882317

申请日：2018-01-29

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dsari Muralidhara Reddy ,  Mogili Narsingam ,  Bandi Vamsi Krishna

IPC: C07D213/82 ,  C07D213/79 ,  C07C231/02 ,  C07D213/14

CPC classification number: C07D213/82 ,  C07C231/02 ,  C07D213/14 ,  C07D213/69 ,  C07D213/79 ,  C07D213/80 ,  C07D213/81 ,  C07D309/40 ,  C07D498/12

Abstract: The present invention provides a novel processes for preparation of methyl 3-(benzyloxy)-5-(2,4-difluorobenzylcarbamoyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyiridine-2-carboxylate using novel intermediates.

公开(公告)号：US20170334858A1

公开(公告)日：2017-11-23

申请号：US14968088

申请日：2015-12-14

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Mogili Narsingam ,  Bandi Vamsi Krishna

IPC: C07D213/82 ,  C07C231/02 ,  C07D213/14 ,  C07D213/79

CPC classification number: C07D213/82 ,  C07C231/02 ,  C07D213/14 ,  C07D213/69 ,  C07D213/79 ,  C07D213/80 ,  C07D213/81 ,  C07D309/40 ,  C07D498/12

Abstract: The present invention provides a novel processes for preparation of methyl 3-(benzyloxy)-5-(2,4-difluorobenzylcarbamoyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyiridine-2-carboxylate using novel intermediates.

公开(公告)号：US09783542B2

公开(公告)日：2017-10-10

申请号：US14436962

申请日：2013-11-01

Applicant: Hetero Research Foundation

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Katham Srinivasa Reddy ,  Bandi Vamsi Krishna

IPC: C07C67/52 ,  C07C67/343 ,  C07D475/08

CPC classification number: C07D475/08 ,  C07C67/343 ,  C07C67/52 ,  C07C69/76

Abstract: The present invention provides a novel process for the purification of alpha-propargylhomoterephthalic acid dimethyl ester substantially free of homoterephthalic acid dimethyl ester. The present invention also provides a novel process for the purification of pralatrexate.

公开(公告)号：US20170088537A1

公开(公告)日：2017-03-30

申请号：US14872743

申请日：2015-10-01

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Matta Ramakrishna Krishna Reddy ,  Bandi Vamsi Krishna

IPC: C07D401/04

CPC classification number: C07D401/04 ,  C07B2200/13

Abstract: The present invention provides a novel process for the preparation of pomalidomide crystalline Form I. The present invention also provides a process for the purification of pomalidomide.

公开(公告)号：US20150291574A1

公开(公告)日：2015-10-15

申请号：US14589575

申请日：2013-07-08

Applicant: Bandi PARTHASARADHI REDDY ,  Kura RATHNAKAR REDDY ,  Dasari MURALIDHARA REDDY ,  Matta RAMAKRISHNA REDDY ,  HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Matta Ramakrishna Reddy ,  Bandi Vamsi Krishna

IPC: C07D413/14

CPC classification number: C07D413/14 ,  C07B2200/13

Abstract: The present invention provides a novel crystalline Form of azilsartan acid, process for its preparation and pharmaceutical compositions comprising it. The present invention also provides a novel crystalline Form of azilsartan medoxomil potassium, process for its preparation and pharmaceutical compositions comprising it.

Abstract translation: 本发明提供了一种新型的唑来硫酸结晶形式，其制备方法和包含它的药物组合物。 本发明还提供了一种新型的吖唑烷酮莫昔米尔钾的结晶形式，其制备方法和包含它的药物组合物。

公开(公告)号：US20150080420A1

公开(公告)日：2015-03-19

申请号：US14319755

申请日：2014-06-30

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC: A61K31/513 ,  A61K31/427

CPC classification number: A61K31/513 ,  A61K31/427 ,  C07D239/10 ,  C07D417/12 ,  A61K2300/00

Abstract: The present invention relates to a novel amorphous Form of lopinavir and ritonavir mixture in the ratio of 3.8:1.2 to 4.2:0.8, process for its preparation and pharmaceutical compositions comprising it.

Abstract translation: 本发明涉及以3.8:1.2至4.2:0.8的比例的洛匹那韦和利托那韦混合物的新型无定形形式，其制备方法和包含它的药物组合物。

公开(公告)号：US20140200356A1

公开(公告)日：2014-07-17

申请号：US14047243

申请日：2013-10-07

Applicant: Hetero Research Foundation

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC: C07D493/04

CPC classification number: C07D493/04 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/34

Abstract: The present invention provides novel solvated forms of darunavir and processes for their preparation. The present invention also provides novel processes for the preparation of darunavir amorphous form and pharmaceutical compositions comprising it. Thus, for example, darunavir 2-methyl-2-butanol solvate was dissolved in methylene dichloride, distilled under vacuum at 45° C. to obtain a residue, cyclohexane was added to the residue and stirred for 30 hours at 20 to 25° C., and the separated solid was filtered, washed with cyclohexane and dried under vacuum at 50° C. for 12 hours to yield darunavir amorphous form.

Abstract translation: 本发明提供了地瑞那韦的新型溶剂化形式及其制备方法。 本发明还提供了制备地瑞那韦非晶形式的新方法和包含它的药物组合物。 因此，例如，将地瑞那韦2-甲基-2-丁醇溶剂合物溶解在二氯甲烷中，在45℃下真空蒸馏，得到残留物，将环己烷加入残留物中，在20〜25℃下搅拌30小时 将分离出的固体过滤，用环己烷洗涤，在50℃下真空干燥12小时，得到地瑞那韦非晶形式。