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公开(公告)号：US11369956B2
公开(公告)日：2022-06-28
申请号：US15546483
申请日：2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Manish Giri , Melinda M. Valencia , Matthew David Smith , Sirena Lu , Joshua M Yu , Sadig Bengali
Abstract: A system may comprise a voltage upconverter, a universal serial bus (USB) connector to receive an input voltage from a USB port on a computing device, and a microfluidic diagnostic chip communication link to electrically couple the voltage upconverter to a microfluidic diagnostic chip wherein the voltage upconverter is to convert the input voltage to be received by the USB connector to an output voltage sufficient to drive a pump on the microfluidic diagnostic chip. A diagnostic system may comprise a microfluidic diagnostic chip comprising a pump and a voltage upconverter to receive an input voltage from a universal serial bus (USB) port of a computing device and to convert the input voltage into an output voltage that powers activation of the pump.
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公开(公告)号：US11203017B2
公开(公告)日：2021-12-21
申请号：US16099668
申请日：2016-07-26
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Jeffrey A Nielsen , Manish Giri , Chantelle Domingue , Kenneth Ward , Christie Dudenhoefer , Matthew David Smith , Joshua M. Yu , Diane R. Hammerstad , Hilary Ely
Abstract: According to an example, a microfluidic apparatus may include a channel, a foyer, in which the foyer is in fluid communication with the channel and in which the channel has a smaller width than the foyer, a sensor to sense a property of a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to determine whether the sensed property of the fluid meets a predetermined condition and to perform a predefined action in response to the sensed property of the fluid meeting the predetermined condition.
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公开(公告)号：US11179720B2
公开(公告)日：2021-11-23
申请号：US16319702
申请日：2016-10-07
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Manish Giri , Chantelle Domingue , Tod Woodford , Matthew David Smith , Rachel M. White , Joshua M. Yu , Hilary Ely , Jeremy Sells
Abstract: The present disclosure is drawn to microfluidic chips. The microfluidic chips can include an inflexible material having an elastic modulus of 0.1 gigapascals (GPa) to 450 GPa. A microfluidic channel can be formed within the inflexible material and can connect an inlet and an outlet. A working electrode can be associated with the microfluidic channel and can have a surface area of 1 μm2 to 60,000 μm2 within the microfluidic channel. A bubble support structure can also be formed within the microfluidic channel such that the working electrode is positioned to electrolytically generate a bubble that becomes associated with the bubble support structure.
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公开(公告)号：US11035814B2
公开(公告)日：2021-06-15
申请号：US15545406
申请日：2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Jeremy Sells , Chantelle E. Domingue , Manish Giri , Melinda M. Valencia
Abstract: A method of microfluidic detection can include detecting, using an impedance sensor, an impedance of a fluid to indicate whether a threshold amount of fluid has been received in a reservoir of a microfluidic chip. The method can include initiating a test performed by the microfluidic chip on the received fluid when the threshold amount of fluid has been received.
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公开(公告)号：US10913065B2
公开(公告)日：2021-02-09
申请号：US15764975
申请日：2016-01-22
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Chantelle E. Domingue , Manish Giri
Abstract: An apparatus includes a chamber, a nozzle connected to the chamber, a fluid driver proximate the driver to expel fluid from the chamber through the nozzle, a microfluidic passage, an inlet connecting the microfluidic passage and the chamber, a sensor proximate the inlet to sense fluid within a fluid sensing zone within the inlet, and a particle aggregation limiter to control aggregation of particles within the sensing zone.
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Patent Agency Ranking
公开(公告)号：US20180285153A1
公开(公告)日：2018-10-04
申请号：US15772463
申请日：2016-02-04
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Joshua M. Yu , Matthew David Smith , Manish Giri , Shameed Salt M A
Abstract: A system and method for managing a microfluidics device. The system includes a microfluidics device; a controller with a first processor which receives outputs from the microfluidics device and provides inputs to the microfluidics device; and a computing device with a second processor and an application program interface (API). The computing device provides instructions to the controller using the API. The instructions are executed by the first processor to produce real-time outputs to the microfluidics device.
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公开(公告)号：US10946379B2
公开(公告)日：2021-03-16
申请号：US15748535
申请日：2016-01-29
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Matthew David Smith , Manish Giri , Chantelle Domingue
Abstract: Provided herein are a system and method for using a microfluidics device. The system includes: a plurality of pumps and a plurality of sensors; a first communication line to select a pump from the plurality of pumps and select a sensor from the plurality of sensors; a second communication line selectively connected to the selected pump; and a third communication line selectively connected to the selected sensor.
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公开(公告)号：US10913066B2
公开(公告)日：2021-02-09
申请号：US15546511
申请日：2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Manish Giri , Chantelle Elizabeth Domingue , Nicholas Matthew Cooper McGuinness , Jeremy Sells , Sirena Lu , Melinda M. Valencia
IPC: B01L99/00 , B01L3/00 , G01N33/543 , G01N15/06 , C12Q1/6804 , C12Q1/00 , G01N15/00
Abstract: A microfluidic diagnostic chip may comprise a microfluidic channel, a functionalizable enzymatic sensor in the microfluidic channel, the functionalizable enzymatic sensor comprising a binding surface to bind with a biomarker in a fluid, and a microfluidic pump to pass the fluid over the binding surface. A microfluidic device may comprise a number of pumps to pump a fluid though the number of microfluidic channels and a number of microfluidic channels comprising at least one sensor to detect a change in a chemical characteristic of the fluid in response to presence of the fluid on the sensor.
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公开(公告)号：US10850275B2
公开(公告)日：2020-12-01
申请号：US15749036
申请日：2016-01-29
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Sadiq Bengali , Manish Giri
IPC: B01L3/00 , G01N33/553
Abstract: A microfluidic diagnostic chip may, in an example, include a number of microfluidic channels defined in a substrate each microfluidic channel fluidly coupled to at least one fluidic slot; the at least one fluidic slot to receive a number of fluids, and a number of gold sensors each gold sensor having a thickness of between 1500 and 5000 angstroms (Å).
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公开(公告)号：US10564171B2
公开(公告)日：2020-02-18
申请号：US15546867
申请日：2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Nicholas Matthew Cooper McGuinness , Chantelle Elizabeth Domingue , Manish Giri , Ed Friesen
Abstract: A microfluidic diagnostic chip may comprise a substrate, a plurality of fluidic slots extending through the substrate, a plurality of microfluidic channels each coupled to a respective one of the plurality of fluidic slots to receive a plurality of fluids from the plurality of fluidic slots, and a mixing region in fluid communication with the plurality of fluidic slots to receive the plurality of fluids such that the plurality of fluids are to mix. A diagnostic chip may comprise a number of fluid slots defined through a substrate and a plurality of microfluidic channels coupled to the fluid slots to receive from the fluid slots a plurality of different fluids wherein the microfluidic channels combine and mix the plurality of different fluids.
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