公开(公告)号：US11698332B2

公开(公告)日：2023-07-11

申请号：US15748393

申请日：2015-11-24

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Robert Moline ,  Manish Giri ,  Chantelle Domingue

IPC: G01N15/06 ,  B01L3/00 ,  C12Q1/25 ,  G01N33/487 ,  G01N33/543 ,  G01N1/38 ,  G01N33/50 ,  G01N15/00

CPC classification number: G01N15/0656 ,  B01L3/502715 ,  C12Q1/25 ,  G01N1/38 ,  G01N33/48707 ,  G01N33/50 ,  G01N33/54366 ,  B01L2200/027 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0442 ,  B01L2400/0487 ,  G01N2015/0065

Abstract: Examples herein provide a device. The device includes a sample delivery component, which includes: a reagent chamber to contain at least one reagent; a sample chamber to contain a fluid sample; and a delivery channel extending from the reagent chamber and in fluid communication with the sample chamber and an output port, wherein the delivery channel is conducive mixing the at least one reagent and the fluid sample to form a mixture before the mixture reaches the output port and be discharged therefrom. The device includes a testing cassette detachable from the delivery component, which includes: an input port in fluid communication with a microfluidic reservoir, the input port to receive the discharged fluid sample from the output port; and a micro-fabricated integrated sensor in a microfluidic channel extending from the microfluidic reservoir.

公开(公告)号：US11007529B2

公开(公告)日：2021-05-18

申请号：US16099658

申请日：2016-07-26

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Jeffrey A Nielsen ,  Manish Giri ,  Chantelle Domingue ,  Kenneth Ward ,  Christie Dudenhoefer ,  Matthew David Smith ,  Joshua M. Yu ,  Hilary Ely

IPC: B01L3/00 ,  G01N15/10 ,  B41J2/175 ,  B41J2/14 ,  G01N35/10 ,  B01L3/02 ,  G01N15/14

Abstract: According to an example, a microfluidic apparatus may include a fluid slot, a foyer in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer, a sensor to detect a presence of a particle of interest in a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to receive information from the sensor, determine, from the received information, whether a particle of interest has passed through the channel, and control the actuator to expel fluid in the foyer through the nozzle based upon the determination.

公开(公告)号：US10272428B2

公开(公告)日：2019-04-30

申请号：US14787230

申请日：2013-04-30

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Nicholas M. McGuinness ,  Manish Giri ,  Melinda M. Valencia ,  Chantelle Domingue ,  Andrew L. Van Brocklin ,  Dustin W. Blair

IPC: B01L3/00 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N15/10

Abstract: A microfluidic device can include: a channel; a fluid inlet to pass fluid into the channel from a reservoir; a sensor disposed in the channel; and a pump actuator disposed in the channel apart from the sensor to induce fluid flow into the channel.

公开(公告)号：US11590495B2

公开(公告)日：2023-02-28

申请号：US16619508

申请日：2017-07-28

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Hilary Ely ,  Matthew David Smith ,  Jeremy Sells ,  George H. Corrigan ,  Michael W. Cumbie ,  Chantelle Domingue

IPC: C12Q1/6876 ,  B01L3/00 ,  B01L7/00 ,  G01N21/64

Abstract: A method may include maintaining a sample comprising an ionic species and an optical indicator at an elevated temperature above 25° C. on a semi-conductive microfluidic die during an incubation period, intermittently interrogating the sample with an interrogating light during the incubation period and sensing a response of the sample to the interrogating light, wherein the sample is interrogated with the interrogating light only during those times at which the sample is being sensed.

公开(公告)号：US11203017B2

公开(公告)日：2021-12-21

申请号：US16099668

申请日：2016-07-26

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Jeffrey A Nielsen ,  Manish Giri ,  Chantelle Domingue ,  Kenneth Ward ,  Christie Dudenhoefer ,  Matthew David Smith ,  Joshua M. Yu ,  Diane R. Hammerstad ,  Hilary Ely

IPC: B01L3/00 ,  B01L3/02 ,  G01N15/10 ,  G01N35/10 ,  G01N15/14

Abstract: According to an example, a microfluidic apparatus may include a channel, a foyer, in which the foyer is in fluid communication with the channel and in which the channel has a smaller width than the foyer, a sensor to sense a property of a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to determine whether the sensed property of the fluid meets a predetermined condition and to perform a predefined action in response to the sensed property of the fluid meeting the predetermined condition.

公开(公告)号：US11179720B2

公开(公告)日：2021-11-23

申请号：US16319702

申请日：2016-10-07

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Manish Giri ,  Chantelle Domingue ,  Tod Woodford ,  Matthew David Smith ,  Rachel M. White ,  Joshua M. Yu ,  Hilary Ely ,  Jeremy Sells

IPC: B01L3/00 ,  F16K99/00

Abstract: The present disclosure is drawn to microfluidic chips. The microfluidic chips can include an inflexible material having an elastic modulus of 0.1 gigapascals (GPa) to 450 GPa. A microfluidic channel can be formed within the inflexible material and can connect an inlet and an outlet. A working electrode can be associated with the microfluidic channel and can have a surface area of 1 μm2 to 60,000 μm2 within the microfluidic channel. A bubble support structure can also be formed within the microfluidic channel such that the working electrode is positioned to electrolytically generate a bubble that becomes associated with the bubble support structure.

公开(公告)号：US11097272B2

公开(公告)日：2021-08-24

申请号：US16099172

申请日：2016-07-26

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Chantelle Domingue ,  Tod Woodford ,  Manish Giri ,  Matthew David Smith ,  George H Corrigan, III ,  Masoud Zavarehi ,  Joshua M. Yu

IPC: B01L3/00 ,  G01N15/10 ,  G01N35/10

Abstract: According to an example, a microfluidic apparatus may include a fluid slot and a foyer that is in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer. The microfluidic apparatus may also include an electrical sensor to measure a change in an electrical field caused by a particle of interest in a fluid passing through the channel from the fluid slot to the foyer, an actuator to apply pressure onto fluid contained in the foyer, and a controller to receive the measured change in the electrical field from the electrical sensor, determine, from the received change in the electrical field, an electrical signature of the particle of interest, and control the actuator to control movement of the particle of interest based upon the determined electrical signature of the particle of interest.

公开(公告)号：US20180015457A1

公开(公告)日：2018-01-18

申请号：US15546735

申请日：2015-01-30

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Nicholas McGuinness ,  Chantelle Domingue ,  Manish Giri ,  Jeremy Sells

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/027 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/088 ,  B01L2300/0883 ,  B01L2300/1827 ,  B01L2400/0442 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N27/07 ,  G01N33/48785

Abstract: A microfluidic diagnostic device may comprise a fluid inlet to receive a fluid from a fluidic slot, a main microfluidic channel fluidly coupled to the fluid inlet, and a main microfluidic pump interposed between the fluid inlet and the main microfluidic channel to continuously circulate a fluid through the fluidic slot, fluid inlet, and main microfluidic channel wherein the width of the fluid inlet is different from the width of the main microfluidic channel. A diagnostic device, comprising a fluidic slot, a fluid inlet fluidly coupled to the fluidic slot, a main channel fluidly coupled to the fluid inlet, and an inlet pump interposed between the fluid inlet and channel wherein the cross-sectional area of the fluid inlet is relatively larger at least one point than the cross-sectional area of the channel.

公开(公告)号：US20180003611A1

公开(公告)日：2018-01-04

申请号：US15546342

申请日：2015-01-30

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Jeremy Sells ,  Nick McGuinness ,  Chantelle Domingue ,  Manish Giri

IPC: G01N15/10 ,  B01L3/00

CPC classification number: G01N15/1056 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0439 ,  B01L2400/0442 ,  G01N15/1031 ,  G01N2015/1006 ,  G01N2015/1062

Abstract: A device including a microfluidic channel structure formed on a substrate and including a first channel and a fluid actuator within the microfluidic channel structure. A sense region within the first channel is to receive a fluid flow of target biologic particles for counting in a single file pattern, with the sense region having a volume on a same order of magnitude as a volume of a single one of the target biologic particles.

公开(公告)号：US10946379B2

公开(公告)日：2021-03-16

申请号：US15748535

申请日：2016-01-29

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Matthew David Smith ,  Manish Giri ,  Chantelle Domingue

IPC: B01L3/00 ,  C12M3/06 ,  G16H40/63 ,  G16H50/20 ,  G11C19/28

Abstract: Provided herein are a system and method for using a microfluidics device. The system includes: a plurality of pumps and a plurality of sensors; a first communication line to select a pump from the plurality of pumps and select a sensor from the plurality of sensors; a second communication line selectively connected to the selected pump; and a third communication line selectively connected to the selected sensor.