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    APPLICATOR
    11.
    发明申请
    APPLICATOR 有权
    申请人

    公开(公告)号：US20140243747A1

    公开(公告)日：2014-08-28

    申请号：US14349523

    申请日：2012-10-02

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Seiji Tokumoto ,  Makoto Ogura

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61B5/150984 ,  A61B5/15117 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

    Abstract: An active agent is effectively administered without giving fear to the user when the microneedles are applied. An applicator 10 includes a transmission member that transmits biasing force of a biasing member to a microneedle array including micro projections (microneedles) with a needle density of 500 needles/cm2 or more. The transmission member has a mass of 1.5 g or less, and the transmission member activated by the biasing force of the biasing member has a momentum of from 0.0083 (N·s) to 0.015 (N·s).

    Abstract translation: 当施用微针时，有效地施用活性剂，而不会对使用者产生恐惧。 涂抹器10包括透射构件，其以500针/ cm 2以上的针密度将偏压构件的偏置力传递到包括微突起（微针）的微针阵列。 传递部件的质量为1.5g以下，由偏置部件的作用力而被驱动的传动部件的动量为0.0083（N·s）〜0.015（N·s）。

    Microneedle sheet
    13.
    发明授权
    Microneedle sheet 有权

    公开(公告)号：US11007358B2

    公开(公告)日：2021-05-18

    申请号：US16325325

    申请日：2017-08-30

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Naoki Yamamoto ,  Seiji Tokumoto

    IPC: A61M37/00 ,  A61K47/36 ,  A61K9/00

    Abstract: A microneedle sheet is disclosed that comprises a plurality of microneedles formed on a sheet generally along a principal surface of the sheet, wherein the microneedles contain a water-soluble polysaccharide and water, the water content is 1 mass % or more and less than 19 mass % based on the total mass of the microneedles, and the microneedles are raised from the principal surface by bending the sheet.

    Applicator
    14.
    发明授权
    Applicator 有权

    公开(公告)号：US09913970B2

    公开(公告)日：2018-03-13

    申请号：US14654029

    申请日：2013-11-27

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Shunsuke Arami ,  Makoto Ogura ,  Seiji Tokumoto

    IPC: A61M37/00 ,  A61K9/00 ,  A61M5/145 ,  A61M5/158

    CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61M5/1454 ,  A61M2005/14506 ,  A61M2005/1585 ,  A61M2037/0023 ,  A61M2037/0046

    Abstract: An applicator includes a piston plate, a non-linear coil spring, a casing, a lock means and a release means. The casing includes a tubular main body part that houses therein the piston plate and the non-linear coil spring, and a cover part that is arranged on one end side of the main body part. The cover part and the piston plate sandwich the non-linear coil spring there between. The lock means locks the piston plate with the casing such that the piston plate is held at a retraction position thereof on the cover part side in a state where the cover part and the piston plate compress the non-linear coil spring. The release means releases a locked state where the piston plate is locked with the casing by the lock means and where the cover part and the piston plate compress the non-linear coil spring.

    Applicator
    15.
    发明授权
    Applicator 有权
    申请人

    公开(公告)号：US09498611B2

    公开(公告)日：2016-11-22

    申请号：US14349523

    申请日：2012-10-02

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Seiji Tokumoto ,  Makoto Ogura

    IPC: A61M37/00 ,  A61B5/151 ,  A61B5/15

    CPC classification number: A61M37/0015 ,  A61B5/150984 ,  A61B5/15117 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

    Abstract: An active agent is effectively administered without giving fear to the user when the microneedles are applied. An applicator 10 includes a transmission member that transmits biasing force of a biasing member to a microneedle array including micro projections (microneedles) with a needle density of 500 needles/cm2 or more. The transmission member has a mass of 1.5 g or less, and the transmission member activated by the biasing force of the biasing member has a momentum of from 0.0083 (N·s) to 0.015 (N·s).

    Abstract translation: 当施用微针时，有效地施用活性剂，而不会对使用者产生恐惧。 涂抹器10包括透射构件，其以500针/ cm 2以上的针密度将偏压构件的偏置力传递到包括微突起（微针）的微针阵列。 传递部件的质量为1.5g以下，由偏置部件的作用力而被驱动的传动部件的动量为0.0083（N·s）〜0.015（N·s）。

    Puncture Device and Method for Manufacturing Same
    17.
    发明申请
    Puncture Device and Method for Manufacturing Same 审中-公开
    穿刺装置及其制造方法

    公开(公告)号：US20150057604A1

    公开(公告)日：2015-02-26

    申请号：US14390260

    申请日：2013-04-02

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Shunsuke Arami ,  Makoto Ogura ,  Seiji Tokumoto

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2207/00 ,  Y10T29/49826

    Abstract: A puncture device is a device for transferring an active ingredient into a body through a skin by piercing the skin with a microneedle. The puncture device comprises a tubular housing, a piston slidably arranged within the housing and having a main surface intersecting a sliding direction, and a nonlinear coil spring arranged within the housing and providing the piston with a biasing force. A plurality of microneedles are arranged on the main surface side.

    Abstract translation: 穿刺装置是通过用微针刺穿皮肤通过皮肤将活性成分转移到身体中的装置。 穿刺装置包括管状壳体，可滑动地布置在壳体内并且具有与滑动方向相交的主表面的活塞和布置在壳体内的非线性螺旋弹簧，并为活塞提供偏置力。 多个微针布置在主表面侧。

    Applicator, cartridge and application kit
    18.
    发明授权
    Applicator, cartridge and application kit 有权

    公开(公告)号：US11642505B2

    公开(公告)日：2023-05-09

    申请号：US16767290

    申请日：2018-11-06

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Takuya Tajima ,  Naoki Yamamoto ,  Seiji Tokumoto

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61M2205/0216

    Abstract: An application kit according to one embodiment includes: a cartridge including a sheet member; and an applicator being connectable to the cartridge. The cartridge includes a bending portion configured to bend the sheet member and a cartridge-side connector configured to be detachably connected to the applicator. The applicator includes: an applicator body; an applicator-side connector provided to a bottom portion of the applicator body; a cap provided above the applicator body and being movable along a height direction of the applicator body; and an elastic member extending along the height direction between the applicator body and the cap and configured to apply, to the cap, an elastic force that acts in a direction away from the bottom portion.

    Applicator
    19.
    发明授权
    Applicator 有权

    公开(公告)号：US10828480B2

    公开(公告)日：2020-11-10

    申请号：US15756234

    申请日：2016-08-19

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Shinpei Nishimura ,  Seiji Tokumoto ,  Masafumi Ono

    IPC: A61M37/00

    Abstract: An applicator according to one embodiment includes a housing having a tubular shape with one closed end, and configured to house an elastic member and a piston plate for transmitting biasing force of the elastic member to the microneedles, and release means configured to release the piston plate engaged in a manner resisting against the biasing force of the elastic member in the housing, to cause the piston plate to move toward an opening of the housing along an axial direction of the housing. The release means is configured, when the release means releases the engagement of the piston plate by moving toward the housing in the axial direction, to transmit force in a direction toward the opening to the housing.

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