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    Ligational encoding of small molecules
    15.
    发明授权
    Ligational encoding of small molecules 有权
    小分子的编码编码

    公开(公告)号：US07915201B2

    公开(公告)日：2011-03-29

    申请号：US10549619

    申请日：2004-03-22

    申请人： Thomas Franch ,  Soeren Nyboe Jacobsen ,  Torben Ravn Rasmussen ,  Soeren Neve ,  Henrik Pedersen ,  Alex Haahr Gouliaev

    发明人： Thomas Franch ,  Soeren Nyboe Jacobsen ,  Torben Ravn Rasmussen ,  Soeren Neve ,  Henrik Pedersen ,  Alex Haahr Gouliaev

    IPC分类号： C40B50/00 ,  C40B30/00

    CPC分类号： C07H21/04 ,  C12N15/1068 ,  C12P21/02 ,  C40B40/06 ,  C40B50/04

    摘要： The invention relates to a method for synthesising a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, said method comprising the steps of i) providing a) at least one template comprising one or more codons capable of hybridising to an anti-codon, wherein said template is optionally associated with one or more chemical entities, and b) a plurality of building blocks each comprising an anti-codon associated with one or more chemical entities, and ii) hybridising the anti-codon of one or more of the provided building blocks to the template, iii) covalently linking said anti-codons and/or linking the at least one template with the anti-codon of at least one building block, thereby generating an identifier polynucleotide capable of identifying chemical entities having participated in the synthesis of the encoded molecule, iv) separating the template from one or more of the anti-codons hybridised thereto, thereby generating an at least partly single stranded identifier polynucleotide associated with a plurality of chemical entities, v) generating a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, wherein said encoded molecule is generated by reacting at least two of said plurality of chemical entities associated with the identifier polynucleotide, and wherein said at least two chemical entities are provided by separate building blocks.

    摘要翻译： 本发明涉及一种合成双功能复合物的方法，所述双功能复合物包含编码分子和识别已经参与编码分子合成的化学实体的标识多核苷酸，所述方法包括以下步骤：i）提供a）至少一个包含一个 或更多能够与抗密码子杂交的密码子，其中所述模板任选地与一个或多个化学实体相关联，以及b）多个结构单元，每个结构单元包含与一个或多个化学实体相关的抗密码子，以及ii） 将一个或多个所提供的构建块的抗密码子与模板杂交，iii）共价连接所述抗密码子和/或将至少一个模板与至少一个构建块的抗密码子连接，由此产生 能够识别已经参与编码分子的合成的化学实体的标识符多核苷酸，iv）将模板从一个或多个分离出来 更多的与其杂交的抗密码子，从而产生与多个化学实体相关联的至少部分单链标识多核苷酸，v）产生包含编码分子的双功能复合物和识别参与合成的化学实体的标识符多核苷酸 的编码分子，其中所述编码的分子通过使与所述标识多核苷酸相关联的所述多个化学实体中的至少两个反应而产生，并且其中所述至少两个化学实体由单独的构建块提供。

    BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
    17.
    发明申请
    BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES 审中-公开
    双功能复合物和制备和使用这种复合物的方法

    公开(公告)号：US20130281324A1

    公开(公告)日：2013-10-24

    申请号：US13641588

    申请日：2011-04-16

    申请人： Alex Haahr Gouliaev ,  Thomas Franch ,  Michael Anders Godskesen ,  Kim Birkebæk Jensen

    发明人： Alex Haahr Gouliaev ,  Thomas Franch ,  Michael Anders Godskesen ,  Kim Birkebæk Jensen

    IPC分类号： C12N15/10

    CPC分类号： C12N15/1065 ,  C12N15/1068

    摘要： The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

    摘要翻译： 本发明涉及一种双官能复合物的合成方法，其包括分子部分和识别分子部分的识别寡核苷酸部分。 当包含任选保护的标签或寡核苷酸标识符的新生双功能复合物与固体支持物连接时，根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，另一部分合成方法为 优选在适合于向溶液中的新生双功能复合物酶促添加寡核苷酸标签的条件下进行。

    Method for selecting a chemical entity from a tagged library
    19.
    发明授权
    Method for selecting a chemical entity from a tagged library 有权
    从标记库选择化学实体的方法

    公开(公告)号：US08722583B2

    公开(公告)日：2014-05-13

    申请号：US11402957

    申请日：2006-04-13

    申请人： Alex Haahr Gouliaev ,  Thomas Franch

    发明人： Alex Haahr Gouliaev ,  Thomas Franch

    IPC分类号： C40B20/04 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12N15/1065 ,  C12N15/1068 ,  C12Q1/6806 ,  C12Q2521/101 ,  C12Q2521/501 ,  C40B50/10 ,  C40B50/16

    摘要： Disclosed is a method for determining the identity of a chemical entity having a preselected property. The chemical entity is identified from a library composed of a plurality of different chemical entities each appended to unique identifier tags. An anti-tag having the capability of specifically interacting with the unique identifier tag is recovered during the method and used for identification purposes.

    摘要翻译： 公开了一种用于确定具有预选性质的化学实体的身份的方法。 从由多个不同化学实体组成的库中识别化学实体，每个化学实体各自附加到唯一标识符标签。 在该方法期间恢复具有与唯一标识符标签特异性交互的能力的反标签，并用于识别目的。

    Ligational encoding of small molecules
    20.
    发明申请
    Ligational encoding of small molecules 有权
    小分子的编码编码

    公开(公告)号：US20060246450A1

    公开(公告)日：2006-11-02

    申请号：US10549619

    申请日：2004-03-22

    申请人： Thomas Franch ,  Soeren Jacobsen ,  Torben Rasmussen ,  Soeren Neve ,  Henrik Pedersen ,  Alex Gouliaev

    发明人： Thomas Franch ,  Soeren Jacobsen ,  Torben Rasmussen ,  Soeren Neve ,  Henrik Pedersen ,  Alex Gouliaev

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P19/34

    CPC分类号： C07H21/04 ,  C12N15/1068 ,  C12P21/02 ,  C40B40/06 ,  C40B50/04

    摘要： The invention relates to a method for synthesising a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, said method comprising the steps of i) providing a) at least one template comprising one or more codons capable of hybridising to an anti-codon, wherein said template is optionally associated with one or more chemical entities, and b) a plurality of building blocks each comprising an anti-codon associated with one or more chemical entities, and ii) hybridising the anti-codon of one or more of the provided building blocks to the template, iii) covalently linking said anti-codons and/or linking the at least one template with the anti-codon of at least one building block, thereby generating an identifier polynucleotide capable of identifying chemical entities having participated in the synthesis of the encoded molecule, iv) separating the template from one or more of the anti-codons hybridised thereto, thereby generating an at least partly single stranded identifier polynucleotide associated with a plurality of chemical entities, v) generating a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, wherein said encoded molecule is generated by reacting at least two of said plurality of chemical entities associated with the identifier polynucleotide, and wherein said at least two chemical entities are provided by separate building blocks.

    摘要翻译： 本发明涉及一种合成双功能复合物的方法，所述双功能复合物包含编码分子和识别已经参与编码分子合成的化学实体的标识多核苷酸，所述方法包括以下步骤：i）提供a）至少一个包含一个 或更多能够与抗密码子杂交的密码子，其中所述模板任选地与一个或多个化学实体相关联，以及b）多个结构单元，每个结构单元包含与一个或多个化学实体相关的抗密码子，以及ii） 将一个或多个所提供的构建块的抗密码子与模板杂交，iii）共价连接所述抗密码子和/或将至少一个模板与至少一个构建块的抗密码子连接，由此产生 能够识别已经参与编码分子的合成的化学实体的标识符多核苷酸，iv）将模板从一个或多个分离出来 更多的与其杂交的抗密码子，从而产生与多个化学实体相关联的至少部分单链标识多核苷酸，v）产生包含编码分子的双功能复合物和识别参与合成的化学实体的标识符多核苷酸 的编码分子，其中所述编码的分子通过使与所述标识多核苷酸相关联的所述多个化学实体中的至少两个反应而产生，并且其中所述至少两个化学实体由单独的构建块提供。