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    ANTIBODY CAPABLE OF SPECIFICALLY RECOGNIZING TRANSFERRIN RECEPTOR
    11.
    发明申请
    ANTIBODY CAPABLE OF SPECIFICALLY RECOGNIZING TRANSFERRIN RECEPTOR 有权
    特异性识别转铁蛋白受体的抗体

    公开(公告)号：US20140114054A1

    公开(公告)日：2014-04-24

    申请号：US14116714

    申请日：2012-05-07

    申请人： Yoshikazu Kurosawa ,  Kazuhiro Morishita ,  Lilin Zhang ,  Gene Kurosawa ,  Katsuyuki Mitomo ,  Yukio Sudo ,  Fumiko Nomura ,  Yoshinori Ukai

    发明人： Yoshikazu Kurosawa ,  Kazuhiro Morishita ,  Lilin Zhang ,  Gene Kurosawa ,  Katsuyuki Mitomo ,  Yukio Sudo ,  Fumiko Nomura ,  Yoshinori Ukai

    IPC分类号： C07K16/30

    CPC分类号： C07K16/30 ,  C07K16/2881

    摘要： An object of present invention is to provide a complete human anti-human TfR antibody, which specifically recognizes human TfR, inhibits the survival or growth of cancer cells that highly express TfR, and has no immunogenicity to humans. The present invention provides an antibody which specifically reacts with human TfR, wherein the antibody comprises any one of the amino acid sequences shown in SEQ ID NOS: 1-3, 7-9, 13-15, 19-21, 25-27, 31-33, 37-39, 43-45, 49-51, 55-57, 61-63, 67-69, 73-75, 79-81, 85-87, 91-93, 97-99, 103-105, 109-111, and 115-117, as each of a heavy chain first complementarity determining region (VH CDR1), a heavy chain second complementarity determining region (VH CDR2), and a heavy chain third complementarity determining region (VH CDR3).

    摘要翻译： 本发明的目的是提供一种完全人抗TfR抗体，其特异性识别人TfR，抑制高表达TfR的癌细胞的存活或生长，并且对人类没有免疫原性。 本发明提供与人TfR特异性反应的抗体，其中所述抗体包含SEQ ID NO： 31-33,37-39,43-45,49-51,55-57,61-63,67-69,73-75,79-81,85-87,91-93,97-99,103- 105，109-111和115-117，作为重链第一互补决定区（VH CDR1），重链第二互补决定区（VH CDR2）和重链第三互补决定区（VH CDR3） 。

    Method for detecting protein
    12.
    发明授权
    Method for detecting protein 有权
    蛋白质检测方法

    公开(公告)号：US07067270B2

    公开(公告)日：2006-06-27

    申请号：US11008954

    申请日：2004-12-13

    申请人： Yukio Sudo

    发明人： Yukio Sudo

    IPC分类号： G01N33/533 ,  G01N33/532 ,  G01N33/535 ,  G01N33/543 ,  G01N33/545

    CPC分类号： G01N33/6845

    摘要： An object of the present invention is to provide a method for detecting a protein using a nonradioactive label which is prevented to a smaller extent than in the case of the interaction of biotin/(strepto)avidin, and which achieves higher detection sensitivity than that of the detection system using DIG. The present invention provides a method for detecting a target substance, which comprises steps of: (A) allowing a target substance to come into contact with a protein labeled with a compound having a 6-membered ring, so as to carry out a binding reaction; and (B) detecting the protein labeled with the compound having a 6-membered ring, which was bound to the target substance, by using an antibody against the above compound having a 6-membered ring.

    摘要翻译： 本发明的目的是提供一种使用非放射性标记物检测蛋白质的方法，其比生物素/（链霉素）抗生物素蛋白相互作用的情况更小程度地被抑制，并且其检测灵敏度比 检测系统采用DIG。 本发明提供一种检测目标物质的方法，其包括以下步骤：（A）使目标物质与由具有6元环的化合物标记的蛋白质接触，以进行结合反应 ; 和（B）通过使用针对具有6元环的上述化合物的抗体来检测用与目标物质结合的具有6元环的化合物标记的蛋白质。

    Integrated microchemical device
    13.
    发明申请
    Integrated microchemical device 审中-公开
    集成微化学装置

    公开(公告)号：US20050202569A1

    公开(公告)日：2005-09-15

    申请号：US11075434

    申请日：2005-03-09

    申请人： Yoshiki Sakaino ,  Yukio Sudo ,  Yoshihiko Abe

    发明人： Yoshiki Sakaino ,  Yukio Sudo ,  Yoshihiko Abe

    IPC分类号： G01N31/20 ,  G01N33/00 ,  G01N33/52 ,  G01N37/00

    CPC分类号： G01N33/525

    摘要： A microchemical device capable of promoting mixing of a specimen and a reagent particularly in analyzing trace constituents of liquid such as blood or body fluid, and a microchemical device that can rapidly and easily analyze one or more constituents from a small amount of specimen, are provided, which is an integrated microchemical device for analyzing one or more constituents of a specimen, the microchemical device comprising at least the two elements of (a) one or more flow channels through which a specimen passes and (b) a multilayer dry analysis element that can come in contact with at least one of the flow channels and analyze the constituents of the specimen.

    摘要翻译： 提供能够促进样品和试剂混合的微化学装置，特别是在分析液体，如血液或体液的微量成分的微量化学装置中，以及能够从少量样品快速，容易地分析一种或多种成分的微化学装置 ，其是用于分析样品的一种或多种成分的集成微量化学装置，所述微化学装置至少包括（a）样品通过的一个或多个流动通道的两个元件和（b）多层干燥分析元件， 可以与至少一个流动通道接触并分析试样的组分。

    Dual-mode thickness-shear quartz pressure sensors for high pressure and high temperature applications
    14.
    发明授权
    Dual-mode thickness-shear quartz pressure sensors for high pressure and high temperature applications 有权
    双模厚度剪切石英压力传感器用于高压和高温应用

    公开(公告)号：US6111340A

    公开(公告)日：2000-08-29

    申请号：US290316

    申请日：1999-04-12

    申请人： Bikash K. Sinha ,  Masaru Niwa ,  Noriyuki Matsumoto ,  Yukio Sudo

    发明人： Bikash K. Sinha ,  Masaru Niwa ,  Noriyuki Matsumoto ,  Yukio Sudo

    IPC分类号： G01L9/00 ,  H01L41/08

    CPC分类号： G01L9/0022

    摘要： A dual-mode thickness-shear quartz pressure transducer includes a unitary piezoelectric crystal resonator and cylindrical housing structure wherein the resonator is located on a median radial plane of the housing and the exterior of the housing is provided with a pair of parallel flat surfaces which are located at an angle relative to the X" axis of the resonator. According to the presently preferred embodiment, the transducer is made from an SC-cut or a WAD-cut solid quartz crystal cylinder which is ultrasonically milled to form a plano-convex or bi-convex resonator disk in the medial radial plane of a hollow cylinder and the pair of exterior flats. The wall thickness of the cylinder is altered at the location of the flats such that stresses at the center of the resonator disk are anisotropic. According to the invention, the ratio of the stresses at the center of the resonator disk along the X" and Z" axes are optimized such that the pressure sensitivity of the third thickness harmonic of C mode vibration is maximized. Optimization of the ratio of the stresses along the X" and Z" axes is accomplished in particular by altering the (azimuthal) angle of the flats. According to a presently preferred embodiment of the invention, the flats are located at an azimuthal angle of approximately 134.degree. relative to the X" axis of a WAD-cut resonator.

    摘要翻译： 双模式厚度剪切石英压力传感器包括单一压电晶体谐振器和圆柱形壳体结构，其中谐振器位于壳体的中间径向平面上，并且壳体的外部设置有一对平行的平坦表面， 相对于谐振器的X'轴成一定角度。 根据目前的优选实施例，换能器由SC切割或WAD切割的固体石英晶体圆柱体制成，其被超声磨削以在中空圆筒的中间径向平面中形成平凸或双凸共振器圆盘 和一对外部单位。 气缸的壁厚在平面的位置处改变，使得谐振器盘的中心处的应力是各向异性的。 根据本发明，谐振器盘沿X“和Z”轴的中心处的应力比被优化，使得C模式振动的第三厚度谐波的压力灵敏度最大化。 通过改变平面的（方位角）角度，可以优化沿X“和Z”轴的应力比例的优化。 根据本发明的当前优选实施例，平面相对于WAD切割谐振器的X“轴位于大约134度的方位角。

    Method of preparing immunological analytical element
    16.
    发明授权
    Method of preparing immunological analytical element 失效
    免疫学分析元素的制备方法

    公开(公告)号：US5266460A

    公开(公告)日：1993-11-30

    申请号：US887425

    申请日：1992-05-20

    申请人： Yukio Sudo ,  Nobuhito Masuda

    发明人： Yukio Sudo ,  Nobuhito Masuda

    IPC分类号： G01N33/543 ,  C12Q1/25 ,  G01N33/535

    CPC分类号： G01N33/54386 ,  Y10S435/969 ,  Y10S435/97

    摘要： A method of preparing a dry-type analytical element for immunoassay having at least one water-permeable porous layer and containing a labeled antigen and an antibody to said labeled antigen and to an unlabeled antigen as the components participating in antigen-antibody reaction in said porous layer, which comprises applying or impregnating a first composition containing one of said labeled antigen and said antibody and thereafter applying or impregnating a second composition containing the other of said labeled antigen and said antibody dissolved or suspended in a solvent not dissolving substantially said labeled antigen or said antibody in the first composition onto said porous layer.

    摘要翻译： 一种制备用于免疫测定的干式分析元件的方法，所述干式分析元件具有至少一个透水性多孔层，并且含有标记的抗原和对所述标记的抗原的抗体以及未标记的抗原作为参与所述多孔的抗原 - 抗体反应的成分 其包括施用或浸渍含有所述标记的抗原和所述抗体之一的第一组合物，然后施用或浸渍含有所述标记的抗原和所述抗体中的另一种的第二组合物，所述第二组合物溶解或悬浮在基本上不溶解所述标记抗原的溶剂中，或者 所述第一组合物中的抗体在所述多孔层上。

    DISPERSION COMPOSITION, COSMETIC PREPARATION FOR SKIN CARE, AND METHOD FOR PRODUCING DISPERSION COMPOSITION
    20.
    发明申请
    DISPERSION COMPOSITION, COSMETIC PREPARATION FOR SKIN CARE, AND METHOD FOR PRODUCING DISPERSION COMPOSITION 审中-公开
    分散组合物，皮肤护理的化妆品制备和生产分散组合物的方法

    公开(公告)号：US20100021511A1

    公开(公告)日：2010-01-28

    申请号：US12522152

    申请日：2007-12-27

    申请人： Tatsuo Kawabuchi ,  Toshiaki Kubo ,  Manabu Ogawa ,  Keiichi Suzuki ,  Tomoko Tashiro ,  Yukio Sudo

    发明人： Tatsuo Kawabuchi ,  Toshiaki Kubo ,  Manabu Ogawa ,  Keiichi Suzuki ,  Tomoko Tashiro ,  Yukio Sudo

    IPC分类号： A61K8/04 ,  A61K8/55 ,  A61K8/35 ,  A61K8/97 ,  A61K31/355 ,  A61Q19/00

    CPC分类号： A61K8/31 ,  A61K8/062 ,  A61K8/553 ,  A61K8/676 ,  A61K2800/21 ,  A61Q19/00

    摘要： The present invention provides: a dispersion composition including a carotenoid-containing oily component, the dispersion composition being obtained by mixing an aqueous dispersion containing emulsion particles containing the carotenoid-containing oily component and a phospholipid or a derivative thereof with an aqueous composition containing ascorbic acid or a derivative thereof and an oily component that is 20% by mass or less relative to the mass of the whole dispersion composition, and the dispersion composition having emulsion particles having an average particle diameter of 200 nm or less; a dispersion composition including a carotenoid-containing oily component, the dispersion composition being obtained by mixing an aqueous dispersion containing emulsion particles containing a carotenoid-containing oily component and a phospholipid or a derivative thereof with an aqueous composition containing ascorbic acid or a derivative thereof and a pH adjusting agent, and the dispersion composition having a pH value in the range of 5 to 7.5; and a cosmetic preparation for skin care including one or other of the dispersion compositions.

    摘要翻译： 本发明提供一种含有类胡萝卜素的油性成分的分散组合物，该分散组合物是将含有含有类胡萝卜素的油性成分的乳液粒子的含水分散体和磷脂或其衍生物与含有抗坏血酸的水性组合物 或其衍生物和油性成分相对于整个分散组合物的质量为20质量％以下，所述分散组合物具有平均粒径为200nm以下的乳液粒子; 包含含类胡萝卜素的油性成分的分散组合物，所述分散组合物通过将含有含类胡萝卜素的油性成分的乳液颗粒和磷脂或其衍生物的含水分散体与含有抗坏血酸或其衍生物的水性组合物混合而得到， pH调节剂，所述分散组合物的pH值在5〜7.5的范围内; 和用于皮肤护理的化妆品制剂，包括一种或其它分散组合物。