公开(公告)号：US12258546B2

公开(公告)日：2025-03-25

申请号：US17561117

申请日：2021-12-23

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Yi Hsu ,  Yang-Cheng Lin ,  Chao-Hong Hsu ,  Yu-Bing Liou ,  Li-Hsin Lin ,  Hsin-Hsin Shen ,  Yu-Chi Wang ,  Chang-Chou Li ,  Chih-Hung Huang

IPC: B01L3/00 ,  C12M1/00 ,  C12M1/42 ,  C12M3/00

Abstract: A cell and tissue sheet forming package includes a container body, a membrane, a sliding door plate and a sealing film. The sliding door plate is disposed slidably on a top of the container body to cover or expose the membrane. The sliding door plate has a hole and a passive magnetic assembly. The cell injection equipment includes a carrier, an injection mechanism and a drive mechanism. The carrier carries the package, and the drive mechanism moves the carrier and the injection mechanism to have the injection mechanism to inject a solution, through the hole, into the package. A heating element of the carrier is introduced to heat the membrane and the solution to transform the solution into a colloid sheet on the membrane. Then, the positive magnetic assembly engages magnetically the passive magnetic assembly to slide the sliding door plate to expose the colloid sheet on the membrane.

公开(公告)号：US11458715B2

公开(公告)日：2022-10-04

申请号：US16675838

申请日：2019-11-06

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Hsin Shen ,  Yu-Chi Wang ,  Ming-Chia Yang ,  Yu-Bing Liou ,  Wei-Hong Chang ,  Yun-Han Lin ,  Hsin-Yi Hsu ,  Yun-Chung Teng ,  Chia-Jung Lu ,  Yi-Hsuan Lee ,  Jian-Wei Lin ,  Kun-Mao Kuo ,  Ching-Mei Chen

IPC: B32B27/36 ,  B05D7/00 ,  B05D5/08 ,  B32B27/24 ,  B32B27/30 ,  B32B38/00 ,  B32B37/02 ,  B32B38/16 ,  B32B37/26

Abstract: A method for preparing a bifunctional film, including: (a) drying a first polymer solution to form a film to form an anti-adhesion layer; and (b) drying a second polymer solution over the anti-adhesion layer to form a film to form an attachment layer. The first polymer solution includes a first hydrophobic solution and a first hydrophilic solution, and in the first polymer solution, the weight ratio of the solute of the first hydrophobic solution to the solute of the first hydrophilic solution is 1:0.01-1. Moreover, the second polymer solution consists of a second hydrophilic solution.

公开(公告)号：US11254902B2

公开(公告)日：2022-02-22

申请号：US16226647

申请日：2018-12-20

Applicant: Industrial Technology Research Institute

Inventor： Ing-Kae Wang ,  Ying-Wen Shen ,  Yea-Tzy Deng ,  Den-Tai Lin ,  Yu-Bing Liou ,  Sing-Ying Hsieh ,  Wei-Zhou Yeh ,  Meng-Hua Yang ,  Hsiang-Chun Hsu ,  Ying-Chun Chien

IPC: C12M1/26 ,  C12M1/40 ,  C12M1/00 ,  C12M3/00 ,  C12M1/12 ,  C12M1/34

Abstract: A cell culture module, a cell culture system and a cell culture method are provided. The cell culture module includes a casing, a first fixer, a second fixer and a sheet-shaped carrier member. The casing has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the casing and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. The sheet-shaped carrier member is formed by arranging a plurality of cell culture carriers, and two opposite ends of the sheet-shaped carrier member are respectively fixed to the first fixer and the second fixer. The sheet-shaped carrier member is in an open state or a folded state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.

公开(公告)号：US11154637B2

公开(公告)日：2021-10-26

申请号：US16675860

申请日：2019-11-06

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Hsin-Hsin Shen ,  Yu-Chi Wang ,  Sen-Lu Chen ,  Yu-Bing Liou ,  Jian-Wei Lin ,  Yi-Hsuan Lee ,  Ming-Chia Yang ,  Ying-Wen Shen ,  Wei-Lin Yu

IPC: A61L24/06 ,  A61L24/00

Abstract: A biodegradable sealant includes: a polyethylene glycol derivative; a photoinitiator; and a solvent, wherein the content of the polyethylene glycol derivative is about 10-75 wt % in the biodegradable sealant. The polyethylene glycol derivative is obtained by a substitution reaction, and in the substitution reaction, the polyethylene glycol is modified with methacrylic anhydride.

公开(公告)号：US10704017B2

公开(公告)日：2020-07-07

申请号：US15854789

申请日：2017-12-27

Applicant: Industrial Technology Research Institute

Inventor： Ying-Wen Shen ,  Ing-Kae Wang ,  Chia-Jung Lu ,  Yea-Tzy Deng ,  Yu-Bing Liou ,  Sing-Ying Hsieh ,  Hsin-Hsin Shen ,  Hsiu-Ying Wang

IPC: C12M1/24 ,  C12M1/42 ,  C12M1/00 ,  C12M3/04 ,  C12M1/12 ,  C12M3/00 ,  C12M1/34

Abstract: A cell culture carrier module and a cell culture system having the same are provided. A cell tank and a culture medium module respectively communicate with the carrier module. The carrier module includes a reactor, a first fixer, a second fixer and a plurality of cell culture carriers. The reactor has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the reactor and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. Two ends of each cell culture carrier are fixed to the first fixer and the second fixer, respectively. The cell culture carriers are in an untwisted state or a twisted state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.

公开(公告)号：US10449272B2

公开(公告)日：2019-10-22

申请号：US15294047

申请日：2016-10-14

Applicant: Industrial Technology Research Institute

Inventor： Yu-Chi Wang ,  Hsin-Hsin Shen ,  Chin-Fu Chen ,  Meng-Yow Hsieh ,  Sen-Lu Chen ,  Yu-Bing Liou ,  Tsai-Yu Lin ,  Pei-Shan Li ,  Wei-Lin Yu

IPC: A61L31/04 ,  A61L31/14

Abstract: The present disclosure provides a hydrogel composition including: a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows: A-B-BOX-B-A, Formula (I); B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II), wherein, A is a hydrophilic polyethylene glycol polymer, B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and an anti-adhesion additive, wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.

公开(公告)号：US09084822B2

公开(公告)日：2015-07-21

申请号：US13871491

申请日：2013-04-26

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Hsin Shen ,  Yu-Bing Liou ,  Chin-Fu Chen ,  Li-Hsin Lin ,  Hsiu-Hua Huang ,  Ying-Hsueh Chao ,  Meng-Yow Hsieh ,  Miao-Tzu Chen ,  Chih-Bing Hung

IPC: A61L27/54 ,  A61K47/34 ,  A61K9/00

CPC classification number: A61K47/34 ,  A61K9/0024

Abstract: The disclosure provides a solid form and a method for preparing the same. The solid form consists essentially of a biodegradable copolymer and an amide-containing compound. The biodegradable copolymer is semi-crystalline due to the dipole-dipole interaction between the biodegradable copolymer and the urea. The method for preparing the above solid form includes: dissolving a biodegradable copolymer and an amide-containing compound in water at a first temperature, obtaining a solution; cooling the solution at a second temperature to form a solid mixture; and the solid mixture is subjected to a freeze-drying process at a third temperature.

Abstract translation: 本公开提供了一种固体形式及其制备方法。 固体形式基本上由可生物降解的共聚物和含酰胺的化合物组成。 由于可生物降解的共聚物和尿素之间的偶极 - 偶极相互作用，生物降解性共聚物是半结晶的。 制备上述固体形式的方法包括：在第一温度下将可生物降解的共聚物和含酰胺的化合物溶解在水中，得到溶液; 在第二温度下冷却溶液以形成固体混合物; 并将固体混合物在第三温度下进行冷冻干燥处理。