中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

54 records (took 0.021 seconds)

    Nanopore sensor for detecting molecular interactions
    11.
    发明授权
    Nanopore sensor for detecting molecular interactions 有权
    用于检测分子相互作用的纳米孔传感器

    公开(公告)号：US09588080B2

    公开(公告)日：2017-03-07

    申请号：US13968061

    申请日：2013-08-15

    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

    Inventor： Binquan Luan ,  Ruhong Zhou

    IPC: G01N27/453 ,  G01N27/447 ,  G01N33/487 ,  B82Y30/00

    CPC classification number: G01N27/44791 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y35/00 ,  G01N27/4473 ,  G01N27/44743 ,  G01N33/48721 ,  Y10S977/742 ,  Y10S977/845 ,  Y10S977/88

    Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.

    Abstract translation: 用于检测分子特征的纳米传感器包括具有开口的膜，该开口被配置为允许带电的碳纳米管通过，但是阻挡附着在碳纳米管上的分子。 开口充满电解液。 电场发生器被配置为相对于开口产生电场，以驱动带电的碳纳米管通过开口。 传感器电路耦合到电场发生器以感测由于带电的碳纳米管进入开口而导致的电流变化，并且偏置电场发生器以确定与碳纳米管和分子之间的分离力相关的临界电压。

    DNA sequencing using multiple metal layer structure with different organic coatings forming different transient bondings to DNA
    14.
    发明授权
    DNA sequencing using multiple metal layer structure with different organic coatings forming different transient bondings to DNA 有权
    使用具有不同有机涂层的多个金属层结构形成与DNA不同的瞬时键合的DNA测序

    公开(公告)号：US09285339B2

    公开(公告)日：2016-03-15

    申请号：US14624868

    申请日：2015-02-18

    Applicant: International Business Machines Corporation

    Inventor： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Hongbo Peng ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  Philip S. Waggoner

    IPC: G01N27/447 ,  B82Y30/00 ,  B82Y15/00 ,  G01N33/487 ,  C12Q1/68

    CPC classification number: G01N33/48721 ,  B82Y15/00 ,  C12Q1/6869 ,  G01N27/44743 ,  G01N27/44791 ,  Y10S977/924 ,  C12Q2563/157

    Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.

    Abstract translation: 纳米器件包括填充有导电流体的储存器和分离储存器的膜。 通过具有由绝缘层分隔的电极层的膜形成纳米孔。 某一电极层具有第一类型的有机涂层，并且一对电极层具有第二类型。 第一类型的有机涂层形成运动控制瞬态键合到用于运动控制的纳米孔中的一个分子，而第二种类型形成与分子的基底的不同键合位点的第一和第二瞬态键。 当对一对电极层施加电压时，由纳米孔中的基底产生隧穿电流，并且隧穿电流通过形成为要测量的第一和第二瞬态键作为用于区分基底的当前签名行进。 运动控制瞬态键比第一和第二瞬态键强。

    NANO-RING GATE ELECTRODE NANOCHANNELS
    15.
    发明申请
    NANO-RING GATE ELECTRODE NANOCHANNELS 有权
    纳米门电极纳米通道

    公开(公告)号：US20150276665A1

    公开(公告)日：2015-10-01

    申请号：US14695390

    申请日：2015-04-24

    Applicant: International Business Machines Corporation

    Inventor： Binquan Luan ,  Sung-wook Nam

    IPC: G01N27/414 ,  C12Q1/68

    CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  G01N27/44791

    Abstract: A technique includes providing a nanodevice. A gate electrode structure has nanochannels with a first end connected to a first common trench and a second end connected to a second common trench. A gate electrode extends laterally as a continuous line on the gate electrode structure and is formed in each of the nanochannels. The gate electrode forms a separate nano-ring electrode around a partial circumference inside each of the nanochannels. The gate electrode is parallel to the first and second common trenches and is perpendicular to the nanochannels.

    Abstract translation: 一种技术包括提供一种纳米设备。 栅极电极结构具有纳米通道，其第一端连接到第一公共沟槽，第二端连接到第二公共沟槽。 栅极电极在栅电极结构上作为连续线横向延伸并形成在每个纳米通道中。 栅电极在每个纳米通道内围绕部分圆周形成单独的纳米环电极。 栅电极平行于第一和第二公共沟槽并且垂直于纳米通道。

    Compressible fluid separator pump
    17.
    发明授权
    Compressible fluid separator pump 有权

    公开(公告)号：US12036507B2

    公开(公告)日：2024-07-16

    申请号：US17672147

    申请日：2022-02-15

    Applicant: International Business Machines Corporation

    Inventor： Bruce Gordon Elmegreen ,  Binquan Luan

    IPC: B01D53/22 ,  B01D53/02 ,  F04B1/00 ,  F04B53/00 ,  F04B53/14

    CPC classification number: B01D53/229 ,  B01D53/02 ,  F04B1/00 ,  F04B53/006 ,  F04B53/14 ,  B01D2053/221 ,  B01D2257/504

    Abstract: A compressible fluid separator pump includes a crankshaft, four cylinders, and four pistons. Each cylinder includes an inlet including an inlet valve for mixed fluid comprising a target component and a discharge component, a reject outlet including a reject valve for a reject fluid, and a select outlet for a select fluid, wherein each of the select outlets includes a separator member that prefers the target component over the discharge component such that the target component is at a higher concentration in the select fluid than in the mixed fluid and in the reject fluid. Each piston is connected to the crankshaft and is positioned in one of the four cylinders, and the crankshaft is configured to position two of the pistons at top dead center when the other two of the pistons are at bottom dead center.

    ANTIGEN-BINDING PROTEINS TARGETING CORONAVIRUS (COV) VARIANTS
    19.
    发明申请
    ANTIGEN-BINDING PROTEINS TARGETING CORONAVIRUS (COV) VARIANTS 有权

    公开(公告)号：US20230073821A1

    公开(公告)日：2023-03-09

    申请号：US17459486

    申请日：2021-08-27

    Applicant: International Business Machines Corporation

    Inventor： Binquan Luan ,  Leili Zhang ,  Tien Huynh

    IPC: C07K16/10

    Abstract: Techniques regarding antigen-binding proteins that can bind to CoV (e.g., SARS-CoV-2) variants are provided. For example, one or more embodiments described herein can comprise an antigen-binding protein that can comprise a heavy polypeptide chain variable region with an amino acid sequence that is a variant of SEQ ID NO: 7. The amino acid sequence can comprise at least one amino acid substitution selected from the group consisting of: R50D, R50E, R50W, R50F, R50Y, R50L, R50V, R50I, R50Pho, I54D, I54E, I54W, I54F, I54Y, I54Pho, L55D, L55E, L55W, L55F, L55Y, and L55Pho.

Patent Agency Ranking