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1.发明申请DNA SEQUENCING USING MULTIPLE METAL LAYER STRUCTURE WITH DIFFERENT ORGANIC COATINGS FORMING DIFFERENT TRANSIENT BONDINGS TO DNA 审中-公开使用多种金属层结构与不同有机涂层形成不同瞬态结合到DNA的DNA序列公开(公告)号：US20170059548A1
公开(公告)日：2017-03-02
申请号：US15349285
申请日：2016-11-11
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Philip S. Waggoner
IPC分类号： G01N33/487 , G01N27/447 , C12Q1/68
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6869 , G01N27/44743 , G01N27/44791 , Y10S977/924 , C12Q2563/157
摘要： A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.
摘要翻译： 纳米器件包括填充有导电流体的储存器和分离储存器的膜。 通过具有由绝缘层分隔的电极层的膜形成纳米孔。 某一电极层具有第一类型的有机涂层，并且一对电极层具有第二类型。 第一类型的有机涂层形成运动控制瞬态键合到用于运动控制的纳米孔中的一个分子，而第二种类型形成与分子的基底的不同键合位点的第一和第二瞬态键。 当对一对电极层施加电压时，由纳米孔中的基底产生隧穿电流，并且隧穿电流通过形成为待测量的第一和第二瞬态键作为用于区分基极的电流签名行进。 运动控制瞬态键比第一和第二瞬态键强。
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2.发明申请公开(公告)号：US20150037843A1
公开(公告)日：2015-02-05
申请号：US14012665
申请日：2013-08-28
IPC分类号： C12P19/34
CPC分类号： C12P19/34 , C12N15/11 , C12Q1/6806 , Y10T436/143333 , C12Q2565/131 , C12Q2565/631
摘要： A mixed polynucleotide includes a first double stranded (ds) portion, a second portion including at least one single stranded (ss) portion, and a third ds portion. The second portion connects the first ds portion and the third ds portion to provide a modified polynucleotide.
摘要翻译： 混合多核苷酸包括第一双链（ds）部分，第二部分包括至少一个单链（ss）部分和第三ds部分。 第二部分连接第一个ds部分和第三个ds部分，以提供修饰的多核苷酸。
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3.发明申请公开(公告)号：US20140174929A1
公开(公告)日：2014-06-26
申请号：US13724041
申请日：2012-12-21
发明人： Binquan Luan , Ruhong Zhou
IPC分类号： G01N27/447
CPC分类号： C12Q1/6869 , B82Y5/00 , B82Y30/00 , G01N27/447 , G01N27/44791 , G01N27/453 , Y10S977/742 , Y10S977/781 , Y10S977/924
摘要： A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.
摘要翻译： 提供用于棘轮双链分子的机制。 双链分子通过第一电压脉冲被驱动到膜的Y通道中。 Y型通道包括杆和支杆，并且分支在连接处连接到杆。 基于第一电压脉冲的Y通道的连接处的双链分子比破坏双链分子的碱基对所需的力弱。 通过在第二电压脉冲下将双链分子驱动到Y通道的结中，将双链分子分成第一单链和第二单链。
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公开(公告)号：US20230073821A1
公开(公告)日：2023-03-09
申请号：US17459486
申请日：2021-08-27
发明人： Binquan Luan , Leili Zhang , Tien Huynh
IPC分类号： C07K16/10
摘要： Techniques regarding antigen-binding proteins that can bind to CoV (e.g., SARS-CoV-2) variants are provided. For example, one or more embodiments described herein can comprise an antigen-binding protein that can comprise a heavy polypeptide chain variable region with an amino acid sequence that is a variant of SEQ ID NO: 7. The amino acid sequence can comprise at least one amino acid substitution selected from the group consisting of: R50D, R50E, R50W, R50F, R50Y, R50L, R50V, R50I, R50Pho, I54D, I54E, I54W, I54F, I54Y, I54Pho, L55D, L55E, L55W, L55F, L55Y, and L55Pho.
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公开(公告)号：US20230043363A1
公开(公告)日：2023-02-09
申请号：US17397046
申请日：2021-08-09
发明人： Rodrigo Neumann Barros Ferreira , Fausto Martelli , BREANNDAN O'CONCHUIR , Tonia Elengikal , Binquan Luan , Ronaldo Giro , Mathias B. Steiner , Anshul Gupta
摘要： A material screening process of generating input features for each material of a subset of materials to be screened, generating target properties for each material of the subset of materials, inputting screening conditions, the input features, and the target properties into a material screening artificial intelligence model and training the material screening artificial intelligence model based on the inputs. Once the model is trained, inputting a dataset of materials to be screened into the trained material screening artificial intelligence model, the dataset of materials includes the subset of materials used to train the model, screening the dataset of materials on the trained material screening artificial intelligence model using the screening conditions and ranking the materials of the dataset based on predicted target properties obtained from the screening.
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公开(公告)号：US20230020787A1
公开(公告)日：2023-01-19
申请号：US17363084
申请日：2021-06-30
发明人： Binquan Luan , Rodrigo Neumann Barros Ferreira , BREANNDAN O'CONCHUIR , Anshul Gupta , Fausto Martelli , Mathias B Steiner , Tonia Elengikal
摘要： A system may include a chamber with a main sub-chamber and a first porous membrane separating a first sub-chamber from the main sub-chamber. The system may include a fluid in the chamber and an input directing inflow into main sub-chamber proximate an entry end of the chamber. The system may include a first output permitting outflow from the first sub-chamber proximate an exit end of the chamber wherein a molecule entering at the entry end must traverse a length of the chamber to exit at the exit end.
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公开(公告)号：US20170234833A1
公开(公告)日：2017-08-17
申请号：US15583501
申请日：2017-05-01
发明人： Binquan Luan , Gustavo A. Stolovitzky , Chao Wang , Deqiang Wang
IPC分类号： G01N27/447 , C12Q1/68 , G01N33/487
CPC分类号： G01N27/44791 , B82Y30/00 , C12Q1/6869 , G01N27/403 , G01N33/48721
摘要： Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.
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公开(公告)号：US09518294B2
公开(公告)日：2016-12-13
申请号：US14615924
申请日：2015-02-06
发明人： Binquan Luan , Ruhong Zhou
IPC分类号： C12Q1/68 , G01N27/447 , G01N27/453 , B82Y30/00 , B82Y5/00
CPC分类号： C12Q1/6869 , B82Y5/00 , B82Y30/00 , G01N27/447 , G01N27/44791 , G01N27/453 , Y10S977/742 , Y10S977/781 , Y10S977/924
摘要： A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.
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公开(公告)号：US20150276664A1
公开(公告)日：2015-10-01
申请号：US14225694
申请日：2014-03-26
发明人： Binquan Luan , Sung-wook Nam
IPC分类号： G01N27/414 , C12Q1/68 , G01N27/447
CPC分类号： G01N27/4145 , C12Q1/6869 , G01N27/44791
摘要： A technique includes providing a nanodevice. A gate electrode structure has nanochannels with a first end connected to a first common trench and a second end connected to a second common trench. A gate electrode extends laterally as a continuous line on the gate electrode structure and is formed in each of the nanochannels. The gate electrode forms a separate nano-ring electrode around a partial circumference inside each of the nanochannels. The gate electrode is parallel to the first and second common trenches and is perpendicular to the nanochannels.
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公开(公告)号：US09146211B1
公开(公告)日：2015-09-29
申请号：US14225694
申请日：2014-03-26
发明人： Binquan Luan , Sung-wook Nam
IPC分类号： C12Q1/68 , G01N27/414 , G01N27/447
CPC分类号： G01N27/4145 , C12Q1/6869 , G01N27/44791
摘要： A technique includes providing a nanodevice. A gate electrode structure has nanochannels with a first end connected to a first common trench and a second end connected to a second common trench. A gate electrode extends laterally as a continuous line on the gate electrode structure and is formed in each of the nanochannels. The gate electrode forms a separate nano-ring electrode around a partial circumference inside each of the nanochannels. The gate electrode is parallel to the first and second common trenches and is perpendicular to the nanochannels.
摘要翻译： 一种技术包括提供一种纳米设备。 栅极电极结构具有纳米通道，其第一端连接到第一公共沟槽，第二端连接到第二公共沟槽。 栅极电极在栅电极结构上作为连续线横向延伸并形成在每个纳米通道中。 栅电极在每个纳米通道内围绕部分圆周形成单独的纳米环电极。 栅电极平行于第一和第二公共沟槽并且垂直于纳米通道。
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