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    DNA chip with micro-channel for DNA analysis
    11.
    发明授权
    DNA chip with micro-channel for DNA analysis 有权

    公开(公告)号：US10100352B2

    公开(公告)日：2018-10-16

    申请号：US14196293

    申请日：2014-03-04

    Applicant: Panasonic Corporation ,  IMEC vzw

    Inventor： Hiroyuki Tanaka ,  Maki Hiraoka ,  Benjamin Jones ,  Paolo Fiorini

    IPC: C12Q1/686 ,  B01L7/00 ,  B01L3/00

    Abstract: Provided is a DNA chip with micro-channel for DNA analysis, which has a structure in which a silicon layer (chip A) and a plastic layer (chip B) are laminated, wherein the chip A includes at least two PCR reactors connected in series in a micro-channel, and a filter between the PCR reactors, the chip B includes a reagent, a liquid delivery mechanism and a sensor in a micro-channel, and the reagent, liquid delivery mechanism and sensor can be changed according to a kind of an analyte and an object to be detected.

    Flow Control System for a Microfluidic Device, Microreactor System, DNA Synthesis Device, and Method for Controlling a Sequence of Reactions
    12.
    发明申请
    Flow Control System for a Microfluidic Device, Microreactor System, DNA Synthesis Device, and Method for Controlling a Sequence of Reactions 有权

    公开(公告)号：US20220032305A1

    公开(公告)日：2022-02-03

    申请号：US17390397

    申请日：2021-07-30

    Applicant: IMEC VZW

    Inventor： Ahmed Taher ,  Benjamin Jones

    IPC: B01L3/00 ,  B01J19/00

    Abstract: A flow control system for a microfluidic device includes: a plurality of fluid flow controllers, each fluid flow controller associated with a respective microfluidic device inlet of the microfluidic device, and wherein each fluid flow controller includes: a controller inlet for receiving a fluid flow, a first fluid channel and a second fluid channel, each of the first and the second fluid channels having a first end connected to the controller inlet and a second end connected to a supply channel, and a valve for selecting the fluid flow to be passed from the controller inlet to the first fluid channel or to the second fluid channel, wherein the first fluid channel has a first flow resistance that smaller than a second flow resistance of the second fluid channel.

    Device for surface functionalization and detection
    13.
    发明授权
    Device for surface functionalization and detection 有权

    公开(公告)号：US11130124B2

    公开(公告)日：2021-09-28

    申请号：US15737013

    申请日：2016-06-20

    Applicant: IMEC VZW

    Inventor： Benjamin Jones ,  Tim Stakenborg ,  Paolo Fiorini

    IPC: B01L3/00 ,  F16K99/00 ,  B05C7/04

    Abstract: A fluidic device is described for locally coating an inner surface of a fluidic channel. The fluidic device comprises a first, a second and a third fluidic channel intersecting at a common junction. The first fluidic channel is connectable to a coating fluid reservoir and the third fluidic channel is connectable to a sample fluid reservoir. The fluidic device further comprises a fluid control means configured for creating a fluidic flow path for a coating fluid at the common junction such that, when coating, a coating fluid propagates from the first to the second fluidic channel via the common junction without propagating into the third fluidic channel. A corresponding method for coating and for sensing also has been disclosed.

    Microstructured Micropillar Arrays for Controllable Filling of a Capillary Pump
    16.
    发明申请
    Microstructured Micropillar Arrays for Controllable Filling of a Capillary Pump 有权
    用于可控填充毛细管泵的微结构微柱阵列

    公开(公告)号：US20150196909A1

    公开(公告)日：2015-07-16

    申请号：US14597716

    申请日：2015-01-15

    Applicant: IMEC VZW

    Inventor： Benjamin Jones ,  Paolo Fiorini

    IPC: B01L3/00

    CPC classification number: B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2300/0838 ,  B01L2300/12 ,  B01L2400/0406 ,  B01L2400/0688 ,  Y10T137/87917

    Abstract: The embodiments of the present disclosure relate to a micro-fluidic device comprising a substrate, a cavity in the substrate and a plurality of micro-pillar columns located inside the cavity. The micro-pillars columns are configured to create a capillary action when a fluid sample is provided in the cavity. A micro-fluidic channel is present between two 5 walls of any two adjacent micro-pillars in a same micro-pillar column. Each of the two walls comprises a sharp corner along the direction of a propagation path of the fluid sample in the micro-fluidic channel thereby forming a capillary stop valve. A notch provided in a sidewall of the cavity acts as a capillary stop valve.

    Abstract translation: 本公开的实施例涉及一种微流体装置，其包括衬底，衬底中的空腔和位于空腔内的多个微柱。 微柱柱配置成当在空腔中提供流体样品时产生毛细管作用。 在相同的微柱柱中的任何两个相邻微柱的两个5壁之间存在微流体通道。 两个壁中的每一个包括沿着微流体通道中的流体样品的传播路径的方向的尖角，从而形成毛细管截止阀。 设置在腔的侧壁中的凹口用作毛细管截止阀。

    Microfluidic Device for Electrically Activated Passive Capillary Stop Valve
    18.
    发明申请
    Microfluidic Device for Electrically Activated Passive Capillary Stop Valve 审中-公开

    公开(公告)号：US20190351415A1

    公开(公告)日：2019-11-21

    申请号：US16410622

    申请日：2019-05-13

    Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R&D

    Inventor： Ujjal Barman ,  Benjamin Jones ,  Paolo Fiorini ,  David Mikaelian

    IPC: B01L3/00 ,  F16K99/00

    Abstract: A microfluidic device for electrically activating a passive capillary stop valve, an apparatus and method are provided. The microfluidic device includes a first channel for containing a first fluid, and an output channel, wherein the first channel comprises a first interface with the output channel, and the first interface comprises a capillary stop valve characterised in that the microfluidic device also comprises a second channel for containing a second fluid, wherein the second channel comprises a second interface with the output channel, and the first channel and the second channel are electrically isolated from each other, and the first interface and the second interface are arranged relative to each other thereby being configured to activate fluid flow from the first channel into the output channel when a first fluid and a second fluid are present, and an electrical potential difference is applied between the first fluid and the second fluid.

    Fast Sample Loading Microfluidic Reactor and System
    19.
    发明申请
    Fast Sample Loading Microfluidic Reactor and System 审中-公开

    公开(公告)号：US20190201893A1

    公开(公告)日：2019-07-04

    申请号：US16217459

    申请日：2018-12-12

    Applicant: IMEC VZW

    Inventor： Benjamin Jones

    IPC: B01L3/00

    CPC classification number: B01L3/5027 ,  B01L2200/141 ,  B01L2300/0819 ,  B01L2300/0867 ,  B01L2400/06

    Abstract: Example embodiments relate to fast sample loading microfluidic reactors and systems. One embodiment includes a microfluidic device. The microfluidic device includes a reaction chamber allowing reacting of at least one fluid material. The microfluidic device also includes at least two fluidic channels coupled to the reaction chamber for providing a fluid to and exiting a fluid from, respectively, the reaction chamber. Each fluidic channel includes an inlet and an outlet. Each fluidic channel is configured such that when a first fluid is provided in the reaction chamber via that fluidic channel, the first fluid exits the reaction chamber via the outlet of at least one other fluidic channel when the reaction chamber is filled, thereby preventing a second fluid from the at least one other fluidic channel, when present in the inlet, from diffusing into the reaction chamber.

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