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    Microfluidic device for electrically activated passive capillary stop valve
    2.
    发明授权
    Microfluidic device for electrically activated passive capillary stop valve 有权

    公开(公告)号：US11110455B2

    公开(公告)日：2021-09-07

    申请号：US16410622

    申请日：2019-05-13

    Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R&D

    Inventor： Ujjal Barman ,  Benjamin Jones ,  Paolo Fiorini ,  David Mikaelian

    IPC: B01L3/00 ,  F16K99/00

    Abstract: A microfluidic device for electrically activating a passive capillary stop valve, an apparatus and method are provided. The microfluidic device includes a first channel for containing a first fluid, and an output channel, wherein the first channel comprises a first interface with the output channel, and the first interface comprises a capillary stop valve characterised in that the microfluidic device also comprises a second channel for containing a second fluid, wherein the second channel comprises a second interface with the output channel, and the first channel and the second channel are electrically isolated from each other, and the first interface and the second interface are arranged relative to each other thereby being configured to activate fluid flow from the first channel into the output channel when a first fluid and a second fluid are present, and an electrical potential difference is applied between the first fluid and the second fluid.

    Fluid analysis device
    3.
    发明授权
    Fluid analysis device 有权

    公开(公告)号：US10427156B2

    公开(公告)日：2019-10-01

    申请号：US15529424

    申请日：2015-11-24

    Applicant: IMEC VZW

    Inventor： Peter Peumans ,  Liesbet Lagae ,  Paolo Fiorini

    IPC: B01L3/00 ,  G01N1/14 ,  G01N1/38 ,  G01N33/49

    Abstract: The present disclosure relates to a fluid analysis device which comprises a sensing device for analyzing a fluid sample, the sensing device comprising a micro-fluidic component for propagating the fluid sample and a microchip configured for sensing the fluid sample in the micro-fluidic component; a sealed fluid compartment containing a further fluid, the compartment being fluid-tight connected to the sensing device and adapted for providing the further fluid to the micro-fluidic component when the sealed fluid compartment is opened; and an inlet for providing the fluid sample to the micro-fluidic component. Further, the present disclosure relates to a method for sensing a fluid sample using the fluid analysis device.

    Microstructured micropillar arrays for controllable filling of a capillary pump
    5.
    发明授权
    Microstructured micropillar arrays for controllable filling of a capillary pump 有权
    用于可控填充毛细管泵的微结构微柱阵列

    公开(公告)号：US09174211B2

    公开(公告)日：2015-11-03

    申请号：US14597716

    申请日：2015-01-15

    Applicant: IMEC VZW

    Inventor： Benjamin Jones ,  Paolo Fiorini

    IPC: F15C1/02 ,  B01L3/00

    CPC classification number: B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2300/0838 ,  B01L2300/12 ,  B01L2400/0406 ,  B01L2400/0688 ,  Y10T137/87917

    Abstract: The embodiments of the present disclosure relate to a micro-fluidic device comprising a substrate, a cavity in the substrate and a plurality of micro-pillar columns located inside the cavity. The micro-pillars columns are configured to create a capillary action when a fluid sample is provided in the cavity. A micro-fluidic channel is present between two 5 walls of any two adjacent micro-pillars in a same micro-pillar column. Each of the two walls comprises a sharp corner along the direction of a propagation path of the fluid sample in the micro-fluidic channel thereby forming a capillary stop valve. A notch provided in a sidewall of the cavity acts as a capillary stop valve.

    Abstract translation: 本公开的实施例涉及一种微流体装置，其包括衬底，衬底中的腔和位于空腔内的多个微柱。 微柱柱配置成当在空腔中提供流体样品时产生毛细管作用。 在相同的微柱柱中的任何两个相邻微柱的两个5壁之间存在微流体通道。 两个壁中的每一个包括沿着微流体通道中的流体样品的传播路径的方向的尖角，从而形成毛细管截止阀。 设置在腔的侧壁中的凹口用作毛细管截止阀。

    Compact glass-based fluid analysis device and method to fabricate
    6.
    发明授权
    Compact glass-based fluid analysis device and method to fabricate 有权

    公开(公告)号：US11241687B2

    公开(公告)日：2022-02-08

    申请号：US15529396

    申请日：2015-11-26

    Applicant: IMEC VZW

    Inventor： Peter Peumans ,  Liesbet Lagae ,  Paolo Fiorini

    IPC: B01L3/00 ,  A61K9/00 ,  B01L9/00

    Abstract: The present disclosure relates to devices and methods for analyzing a fluid sample. An example device comprises a fluidic substrate comprising a micro-fluidic component embedded therein, for propagating a fluid sample; a needle or inlet for providing the fluid sample which is fluidically connected to the micro-fluidic component; a lid attached to the fluidic substrate thereby at least partly covering the fluidic substrate and at least partly closing the micro-fluidic component; wherein the fluidic substrate is a glass fluidic substrate and wherein the lid is a microchip. The present disclosure also relates to a method for fabricating a fluid analysis device. The method comprises providing a fluidic substrate; providing a lid; attaching the lid to the fluidic substrate to close the fluidic substrate at least partly.

    Device for Surface Functionalization and Detection
    7.
    发明申请
    Device for Surface Functionalization and Detection 有权

    公开(公告)号：US20220008917A1

    公开(公告)日：2022-01-13

    申请号：US17475807

    申请日：2021-09-15

    Applicant: Imec vzw

    Inventor： Benjamin Jones ,  Tim Stakenborg ,  Paolo Fiorini

    IPC: B01L3/00 ,  F16K99/00

    Abstract: A fluidic device (100) is described for locally coating an inner surface of a fluidic channel. The fluidic device (100) comprises a first (101), a second (102) and a third (103) fluidic channel intersecting at a common junction (105). The first fluidic channel is connectable to a coating fluid reservoir and the third fluidic channel is connectable to a sample fluid reservoir. The fluidic device (100) further comprises a fluid control means (111) configured for creating a fluidic flow path for a coating fluid at the common junction (105) such that, when coating, a coating fluid propagates from the first (101) to the second (102) fluidic channel via the common junction (105) without propagating into the third (103) fluidic channel. A corresponding method for coating and for sensing also has been disclosed.

    Combined Extraction and PCR Systems
    8.
    发明申请
    Combined Extraction and PCR Systems 审中-公开

    公开(公告)号：US20190309346A1

    公开(公告)日：2019-10-10

    申请号：US16448713

    申请日：2019-06-21

    Applicant: IMEC VZW

    Inventor： Tim Stakenborg ,  Paolo Fiorini

    IPC: C12Q1/6806 ,  B01L3/00 ,  B01L7/00

    Abstract: The disclosure provides methods and systems for analyzing fluid samples comprising obtaining fluid samples in at least one cavity of a substrate and introducing also buffers and/or reagents in the cavity, performing nucleic acid extraction and/or purification in the cavity, and performing nucleic acid amplification in the same cavity.

    Compact Glass-Based Fluid Analysis Device and Method to Fabricate
    9.
    发明申请
    Compact Glass-Based Fluid Analysis Device and Method to Fabricate 审中-公开

    公开(公告)号：US20170326546A1

    公开(公告)日：2017-11-16

    申请号：US15529396

    申请日：2015-11-26

    Applicant: IMEC VZW

    Inventor： Peter Peumans ,  Liesbet Lagae ,  Paolo Fiorini

    IPC: B01L3/00 ,  A61K9/00 ,  B01L9/00

    CPC classification number: B01L3/502707 ,  A61K9/0014 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/50857 ,  B01L3/565 ,  B01L9/527 ,  B01L2200/10 ,  B01L2300/0645

    Abstract: The present disclosure relates to devices and methods for analyzing a fluid sample. An example device comprises a fluidic substrate comprising a micro-fluidic component embedded therein, for propagating a fluid sample; a needle or inlet for providing the fluid sample which is fluidically connected to the micro-fluidic component; a lid attached to the fluidic substrate thereby at least partly covering the fluidic substrate and at least partly closing the micro-fluidic component; wherein the fluidic substrate is a glass fluidic substrate and wherein the lid is a microchip. The present disclosure also relates to a method for fabricating a fluid analysis device. The method comprises providing a fluidic substrate; providing a lid; attaching the lid to the fluidic substrate to close the fluidic substrate at least partly.

    Combined extraction and PCR systems
    10.
    发明授权
    Combined extraction and PCR systems 有权

    公开(公告)号：US11220706B2

    公开(公告)日：2022-01-11

    申请号：US16448713

    申请日：2019-06-21

    Applicant: IMEC VZW

    Inventor： Tim Stakenborg ,  Paolo Fiorini

    IPC: C12Q1/6806 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

    Abstract: The disclosure provides methods and systems for analyzing fluid samples comprising obtaining fluid samples in at least one cavity of a substrate and introducing also buffers and/or reagents in the cavity, performing nucleic acid extraction and/or purification in the cavity, and performing nucleic acid amplification in the same cavity.

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