摘要:
The present invention discloses compounds having the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is --COR.sup.4, --CN, --CH.sub.2 R.sup.5, halogen, --CH.dbd.CHR.sup.6 or Q and the other is hydrogen or lower alkyl or both R.sup.1 and R.sup.2 together form a .gamma.-lactam ring,R.sup.3 is hydrogen, lower alkyl, aryl-alkyl, allyl or a residue which is cleavable in vivo,R.sup.4 is hydrogen, lower alkyl, lower alkoxy, benzyloxy, amino, lower alkylamino or lower alkyl-lower alkoxyamino,R.sup.5 is hydroxy, --OCONHR.sup.7, --OCONH.sub.2 or a five- or six-membered hetero-aromatic ring which contains N,S and/or O and which is linked via a nitrogen atom,R.sup.6 is --CN or CHO,R.sup.7 is --COCH.sub.2 Cl,Q is a five- or six-membered hetero-aromatic ring which contains N, S and/or O andn is 0, 1 or 2,and the pharmaceutically compatible salts thereof.These compounds are good .beta.-lactamase inhibitors. They can be used for the prevention or treatment of bacterial infections, optionally together with a .beta.-lactam antibiotic.
摘要:
A method and apparatus for installing an underground seal beneath a garbage dump in a strip-like manner. The earth is worked in strips under the garbage dump by the front end of a driving shield. The earth is transported to the rear end of the driving shield, and is compressed at the rear end. A strip-like layer of a waterproof material is inserted, under the protection of a cover of the driving shield. A supply tunnel pipe is constructed and subsequently dismantled, comprised of individual tunnel pipe sections, under the protection of the cover while the driving shield is moved forward. The dismantled tunnel pipe sections of the tunnel pipe are used to erect an additional tunnel pipe which is laterally displaced in a direction toward the next strip-like layer opposite the first one tunnel pipe behind the driving shield. By stabilizing the dismantled pipe sections they need not be dragged along or transported out of the remaining tunnel pipe.
摘要:
An industrial robot of the type comprising a frame mounted for rotation about a horizontal axis and having a pivot arm which is pivotally attached to the frame for pivotally supporting a boom, is provided with a counterbalancing device for equalizing the weight of the boom. The counterbalancing device includes a toggle lever mounted for pivotal motion about a fixed horizontal axis that extends at right angles to the axis of rotation of the frame, a counterweight or piston being connected to the toggle lever at a point spaced from one side of the pivot axis of the toggle lever, and a linkage connecting a second point on the toggle lever, located on the other side of its pivot axis, to the pivot arm at a location that is spaced from the pivot axis between the pivot arm and frame.
摘要:
An angle encoder, for measuring the angular position of a shaft, comprises at least two code carriers having correlated code indicia thereon, the two code carriers being coupled to the shaft for concurrent movement therewith past a scanning unit, and being so arranged that the relative position of the two code carriers changes successively during successive revolutions of the shaft. The two code carriers can comprise endless code tapes having different lengths, or mesh-engaged code disks having different sizes.
摘要:
This invention relates to novel 3-aminopyridines of the formula wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
摘要:
In a universal drive with a rotatable or linearly movable drive member and piezo actuators supported on a carrier for acting on a leg supported on the drive member and moving the leg in a high-frequency stepping sequence in a drive direction, wherein the carriers are jointly supported on a stator by a pretension member which biases them elastically toward the drive member via an elbow lever mechanism including a first elbow lever and at least a second elbow lever which are both connected to an actuator by a coupling member and this arrangement is such that, with the first elbow lever stretched, the second elbow lever is kinked and vice versa.
摘要:
This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
摘要:
The present invention relates to compounds of formula (I), as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein A, B, R1, R2, R3, R4, R5, n, m and p have the significance defined herein.
摘要:
This invention relates to novel cyclopentyl- and cycloheptylpyrazole derivatives of the formula I wherein A and R1 to R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. The invention relates also to compositions including these compounds and methods of using the compounds.
摘要:
The invention is concerned with novel benzimidazole derivatives of formula (I) wherein A, n and R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.