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公开(公告)号：US20200369771A1
公开(公告)日：2020-11-26
申请号：US16605865
申请日：2018-04-11
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Andrey Borisovich ULITIN , Victoria Mikhailovna EKIMOVA , Ekaterina Vladimirovna SOFRONOVA, , Yulia Sergeevna CHERNYKH , Sergei Andreevich AGEEV , Anna Konstantinovna VLADIMIROVA , Aleksei Aleksandrovich ALEKSANDROV , Pavel Alekseevich GREBNEV , Valery Vladimirovich SOLOVYEV , Iakov Iurevich USTIUGOV , Pavel Andreevich IAKOVLEV , Timofey Aleksandrovich NEMANKIN , Dmitry Valentinovich MOROZOV
IPC: C07K16/28 , A61K45/06 , A61K39/395
Abstract: The present invention relates to the field of biotechnology and provides antibodies that specifically binds to PD-L1. The invention also relates to DNA encoding said antibodies, to corresponding expression vectors and to methods of producing, and to methods of treatment using said antibodies.
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公开(公告)号：US20200270345A1
公开(公告)日：2020-08-27
申请号：US16753587
申请日：2018-10-03
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Kirill Vladimirovich SOLOVYEV , Andrei Borisovich ULITIN , Timofey Aleksandrovich NEMANKIN , Valery Vladimirovich SOLOVYEV , Dmitry Valentinovich MOROZOV
IPC: C07K16/28
Abstract: The present invention relates to the field of bioengineering, specifically to antibodies or their antigen-binding fragments, and to the use thereof. More particularly, the present invention relates to antibodies that bind specifically to CD47 and PD-L1. The invention also relates to a nucleic acid that codes for the given antibody or for the antigen-binding fragment thereof, to an expression vector, to a method of producing the antibody, and to a use of the aforementioned antibodies and compositions in cancer treatment.
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公开(公告)号：US20250154526A1
公开(公告)日：2025-05-15
申请号：US18684984
申请日：2022-08-18
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Anna Nikolaevna STRELKOVA , Sergei Aleksandrovich LEGOTSKII , Tatiana Evgenievna SHUGAEVA , Pavel Mikhailovich GERSHOVICH , Alexandr Anatolevich NADOLINSKII , Pavel Andreevich IAKOVLEV , Dmitry Valentinovich MOROZOV
IPC: C12N15/86 , A61K48/00 , C07K14/005 , G16B20/50 , G16B30/10
Abstract: The present application relates to the fields of gene therapy and molecular biology. More specifically, the present invention relates to a method for producing a modified adeno-associated virus (AAV) capsid and to a modified AAV capsid produced by said method, as well as to an isolated nucleic acid encoding said modified capsid and a vector based on recombinant adeno-associated virus for delivering a heterologous nucleic acid sequence to a subject, which includes said modified capsid.
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公开(公告)号：US20240076691A1
公开(公告)日：2024-03-07
申请号：US18280338
申请日：2022-03-05
Inventor： Alexander Vladimirovich PROKOFYEV , Pavel Mikhailovich GERSHOVICH , Anna Nikolaevna STRELKOVA , Natalia Aleksandrovna SPIRINA , Tatiana Evgenievna SHUGAEVA , Dmitry Valentinovich MOROZOV
CPC classification number: C12N15/86 , A61K48/005 , A61P7/04 , C12N9/644 , C12N2750/14122 , C12N2750/14143 , C12Y304/21022
Abstract: The present application relates to the fields of genetics, gene therapy, and molecular biology. More specifically, the present invention relates to an isolated codon-optimized nucleic acid that encodes the FIX (coagulation factor IX) protein, an expression cassette and a vector based thereon, as well as an AAV5 (adeno-associated virus serotype 5)-based recombinant virus for increasing the expression of the FIX gene in target cells, and use thereof.
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公开(公告)号：US20230011234A1
公开(公告)日：2023-01-12
申请号：US17761838
申请日：2020-09-20
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Andrei Borisovich ULITIN , Aleksey Vladimirovich KONONOV , Sergei Andreevich AGEEV , Aleksandr Andreevich GORDEEV , Elena Vladimirovna VINOGRADOVA , Stanislav Rudolfovich EVDOKIMOV , Aleksandra Pavlovna SHMAKOVA , Ivan Vladimirovich MITROSHIN , Dmitry Valentinovich MOROZOV
IPC: C07K14/54 , C07K14/715 , A61P35/00
Abstract: The present invention relates to an immunocytokine comprising an heterodimeric protein complex based on IL-15/IL-15Rα, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease. The present invention further relates to an immunocytokine comprising a heterodimeric protein complex based on an IL-15/IL-15Rα and an immunomodulatory antibody, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease.
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Patent Agency Ranking
公开(公告)号：US20220372127A1
公开(公告)日：2022-11-24
申请号：US17599380
申请日：2020-04-02
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Ekaterina Valerevna CHERNIAEVA , Ekaterina Aleksandrovna LOMKOVA , Antonina Vasilevna ARTEMEVA , Anna Viktorovna EREMEEVA , Roman Alekseevich IVANOV , Anastasiya Mikhajlovna RYAKHOVSKAYA , Viktoriia Olegovna SHITIKOVA , Aleksandr Olegovich IAKOVLEV , Dmitry Valentinovich MOROZOV
Abstract: The present disclosure relates to aqueous compositions for anti-IL17a antibodies, and more particularly to aqueous compositions for anti-IL17a antibodies with a VHH variable domain and a VL variable domain, and can be used as a medicinal agent for treating IL-17A-mediated diseases.
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公开(公告)号：US20200339544A1
公开(公告)日：2020-10-29
申请号：US16753847
申请日：2018-10-05
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Kirill Vadimovich ZAVIALOV , Svetlana Leonidovna GORBUNOVA , Artsiom Evgenievich SHEKHAUTSOU , Mariia Andreevna KASATKINA , Daria Dmitrievna BEKETOVA , Natalia Vladimirovna KOZHEMYAKINA , Kirill Igorevich KULISH , Elena Aleksandrovna MAKSIMENKO , Marina Viktorovna MELESHINA , Olga Anatolevna MELCHAEVA , Aleksei Leonidovich MINDICH , Dmitry Valentinovich MOROZOV , Aleksandra Vladimirovna POPKOVA , Ilia Alexeevich SMETANIN , Sergey Aleksandrovich SILONOV , Iaroslavna Alexandrovna SOLDATOVA , Georgii Viktorovich IAKOBSON
IPC: C07D403/06 , C07D239/42 , C07D213/74 , C07D413/10 , C07D401/06 , A61P35/00
Abstract: The present invention relates to novel compounds of formula I, or pharmaceutically acceptable salts, solvates or stereoisomers thereof, also to a pharmaceutical composition, a method for inhibiting biological activity of epidermal growth factor receptor (EGFR), a method for treating diseases or disorders mediated by the activation of EGFR and use of the present compounds or the present pharmaceutical composition for the treatment of a disease or disorder mediated by the activation of EGFR.
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公开(公告)号：US20240091383A1
公开(公告)日：2024-03-21
申请号：US18274496
申请日：2022-01-28
Applicant: JOINT STOCK COMPANY «BIOCAD»
Inventor： Dmitriy Aleksandrovich MADERA , Anna Sergeevna VESELOVA , Aleksei Sergeevich SIUTKIN , Pavel Mikhailovich GERSHOVICH , Dmitry Valentinovich MOROZOV
CPC classification number: A61K48/0058 , C12N15/86 , C12N2310/141 , C12N2310/31 , C12N2750/14143
Abstract: The present application relates to the fields of biotechnology, virology, genetics, and molecular biology. More specifically, the present invention relates to an isolated nucleic acid for producing a gene therapy viral product, said isolated nucleic acid comprising a nucleic acid that encodes the SMN1 protein having the amino acid sequence of SEQ ID NO: 1, and a nucleic acid that encodes the microRNA miR-23a, an expression cassette and a vector based thereon, as well as an AAV9-based recombinant virus for expressing the SMN1 gene in target cells, a pharmaceutical composition that includes said recombinant virus, and various uses of the above recombinant virus and the above composition.
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公开(公告)号：US20230203171A1
公开(公告)日：2023-06-29
申请号：US17998567
申请日：2021-06-07
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Dmitrii Aleksandrovich TOLSTYKH , Alina Aleksandrovna TSUKUR , Ekaterina Aleksandrovna LOMKOVA , Aleksandr Olegovich IAKOVLEV , Anton Aleksandrovich LUTCKII , Iuliia Nikolaevna LINKOVA , Arina Valerevna ZINKINA-ORIKHAN , Dmitry Valentinovich MOROZOV
CPC classification number: C07K16/2866 , A61K47/12 , A61K47/10 , A61K47/183 , A61K31/519 , A61K9/08 , A61P19/02 , A61P37/06 , C07K2317/21
Abstract: The disclosure relates to the field of pharmacy and medicine, specifically to aqueous compositions of anti-IL-6R antibody levilimab which may be used as a medicinal product for treating IL-6R-associated diseases.
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公开(公告)号：US20220213209A1
公开(公告)日：2022-07-07
申请号：US17605933
申请日：2020-04-23
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Andrei Borisovich ULITIN , Olesya Nikolaevna KOZLOVA , Aleksandr Andreevich GORDEEV , Ksenia Mihailovna BURNYSHEVA , Anastasia Nikolaevna ISHUTINOVA , Aleksandra Aleksandrovna SOZONOVA , Sergei Andreevich AGEEV , Aleksandr Nikolaevich DORONIN , Vladimir Sergeevich TSYMPILOV , Ivan Vladimirovich MITROSHIN , Valery Vladimirovich SOLOVYEV , Iakov Iurevich USTIUGOV , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV
Abstract: The present invention relates to biotechnology, in particular to antibodies or antigen-binding fragments thereof, and to use thereof. More particularly, the present invention relates to monoclonal antibodies that specifically bind to GITR. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with GITR.
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